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Peer-reviewedCC BY-NCCase Reports in Women's Health

Clear cell carcinoma of the uterine corpus arising in long-standing adenomyosis after menopause: a case report

  • Genichiro To1
  • Ai Shinto2
  • Asako Fukuda2
  • Mariko Hashiguchi3
  • Seiichi Kato3
  • Yasushi Umezaki2
  • Kaoru Okugawa2
  1. 1Department of Obstetrics and Gynecology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga City, Saga, 849-8501, Japan; Corresponding author at: Department of Obstetrics and Gynecology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga City, Saga 849-8501, Japan.
  2. 2Department of Obstetrics and Gynecology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga City, Saga, 849-8501, Japan
  3. 3Department of Pathology and Microbiology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga City, Saga, 849-8501, Japan
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Abstract

Clear cell carcinoma arising from ovarian endometrioma is well documented; however, its origin from uterine adenomyosis is exceptionally rare. A 60-year-old postmenopausal woman with long-standing adenomyosis and no gynecologic follow-up for approximately 10 years presented with a 7 cm pelvic mass detected on routine health screening. Magnetic resonance imaging revealed an intramural mass with mixed cystic and solid components, restricted diffusion, and contrast enhancement. Despite the absence of uterine bleeding and negative cervical and endometrial cytology, malignancy was suspected. Total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed. Histopathology confirmed clear cell carcinoma arising in adenomyosis, with transition foci from benign adenomyosis to carcinoma. This case highlights that clear cell carcinoma arising in adenomyosis should be considered when a long-standing cystic uterine lesion enlarges and develops suspicious imaging features, even in the absence of uterine bleeding or cytological abnormalities.

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Cite

BibTeXRIS
BibTeX
@article{to2026clear,
  title = {{Clear cell carcinoma of the uterine corpus arising in long-standing adenomyosis after menopause: a case report}},
  author = {Genichiro To and Ai Shinto and Asako Fukuda and Mariko Hashiguchi and Seiichi Kato and Yasushi Umezaki and Kaoru Okugawa},
  journal = {Case Reports in Women's Health},
  year = {2026},
  month = oct,
  doi = {10.1016/j.crwh.2026.e00866},
  url = {https://doi.org/10.1016/j.crwh.2026.e00866},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Clear cell carcinoma of the uterine corpus arising in long-standing adenomyosis after menopause: a case report
AU  - Genichiro To
AU  - Ai Shinto
AU  - Asako Fukuda
AU  - Mariko Hashiguchi
AU  - Seiichi Kato
AU  - Yasushi Umezaki
AU  - Kaoru Okugawa
PY  - 2026
DA  - 2026/10/21
JO  - Case Reports in Women's Health
DO  - 10.1016/j.crwh.2026.e00866
UR  - https://doi.org/10.1016/j.crwh.2026.e00866
AB  - Clear cell carcinoma arising from ovarian endometrioma is well documented; however, its origin from uterine adenomyosis is exceptionally rare. A 60-year-old postmenopausal woman with long-standing adenomyosis and no gynecologic follow-up for approximately 10 years presented with a 7 cm pelvic mass detected on routine health screening. Magnetic resonance imaging revealed an intramural mass with mixed cystic and solid components, restricted diffusion, and contrast enhancement. Despite the absence of uterine bleeding and negative cervical and endometrial cytology, malignancy was suspected. Total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed. Histopathology confirmed clear cell carcinoma arising in adenomyosis, with transition foci from benign adenomyosis to carcinoma. This case highlights that clear cell carcinoma arising in adenomyosis should be considered when a long-standing cystic uterine lesion enlarges and develops suspicious imaging features, even in the absence of uterine bleeding or cytological abnormalities.
SN  - 2214-9112
ER  -