Comparing the Cutaneous Impacts of a Topical Restructuring Serum versus. Injected Hyaluronic Acid (HA) and Their Combination as Potential Anti-Aging Strategies in Chinese Women: An In Vivo Study
4 affiliations
- 1L’Oréal Research and Innovation, Shanghai, China
- 2TING S.A, Angers, France
- 3L’Oréal Research and Innovation, 9 Rue Pierre Dreyfus, 92110 Clichy, France
- 4Centre Médical Laser Palaiseau, Palaiseau, France
Abstract
Introduction: To investigate the respective anti-aging efficacies of a restructuring serum alone, its combination with a hyaluronic acid (HA) single injection, and a single HA injection alone in vivo over a short period.
Methods: Three cohorts of Chinese women of comparable sizes (n = 31–32), aged 25–40 years, were included in this 28-day, nonrandomized, evaluator-blinded comparative study. The three regimens consisted of: (1) twice-daily application of a marketed skin restructuring serum alone, (2) application of the same serum after a HA injection, and (3) a single HA injection only. Participants were instructed to apply approximately 0.5 g on full face twice daily. At successive timings (T0–T28 days), clinical evaluations allowed for the grading of some facial signs, skin quality, and skin tone. Image analysis from standardized photos and dedicated analyzing cameras were performed. A self-reported questionnaire was filled to record the tolerance of the three regimens.
Results: All three regimens improved the severity of facial signs, skin quality, and skin tone. However, their efficacy was of different extents. In many cases, although the serum provided significant improvements, its combination with HA injection led to slightly greater improvement and in almost all cases, the HA injection alone exhibited a lower efficacy, i.e., 2−3 times smaller in some criteria. Adverse reactions (pain, stinging, tightness etc.) to the HA injection were only recorded 1 h postinjection and were statistically of modest amplitudes.
Conclusions: Although limited to a short period and to women presenting modest marks of facial aging (early aging), the study demonstrated that all three regimens showed improvements in several evaluated facial ageing parameters. The combination of the restructuring serum with an HA injection provided an additional benefit compared with HA or serum alone.
Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s13555-026-01906-8.
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BibTeX
@article{li2026comparing,
title = {{Comparing the Cutaneous Impacts of a Topical Restructuring Serum versus. Injected Hyaluronic Acid (HA) and Their Combination as Potential Anti-Aging Strategies in Chinese Women: An In Vivo Study}},
author = {Jing Li and Xingzuo Liu and Liang Zhang and Yun Wang and Shumei Li and Wei Le and Yidong Tu and Kungchi Hsu and Ji Zhang and Andrew Steel and Didier Saint-Leger and Frederic Flament and Diala Haykal},
journal = {Dermatology and Therapy},
year = {2026},
month = sep,
doi = {10.1007/s13555-026-01906-8},
url = {https://doi.org/10.1007/s13555-026-01906-8},
note = {CC BY-NC 4.0},
}
RIS
TY - JOUR
TI - Comparing the Cutaneous Impacts of a Topical Restructuring Serum versus. Injected Hyaluronic Acid (HA) and Their Combination as Potential Anti-Aging Strategies in Chinese Women: An In Vivo Study
AU - Jing Li
AU - Xingzuo Liu
AU - Liang Zhang
AU - Yun Wang
AU - Shumei Li
AU - Wei Le
AU - Yidong Tu
AU - Kungchi Hsu
AU - Ji Zhang
AU - Andrew Steel
AU - Didier Saint-Leger
AU - Frederic Flament
AU - Diala Haykal
PY - 2026
DA - 2026/09/01
JO - Dermatology and Therapy
DO - 10.1007/s13555-026-01906-8
UR - https://doi.org/10.1007/s13555-026-01906-8
AB - Introduction: To investigate the respective anti-aging efficacies of a restructuring serum alone, its combination with a hyaluronic acid (HA) single injection, and a single HA injection alone in vivo over a short period. Methods: Three cohorts of Chinese women of comparable sizes (n = 31–32), aged 25–40 years, were included in this 28-day, nonrandomized, evaluator-blinded comparative study. The three regimens consisted of: (1) twice-daily application of a marketed skin restructuring serum alone, (2) application of the same serum after a HA injection, and (3) a single HA injection only. Participants were instructed to apply approximately 0.5 g on full face twice daily. At successive timings (T0–T28 days), clinical evaluations allowed for the grading of some facial signs, skin quality, and skin tone. Image analysis from standardized photos and dedicated analyzing cameras were performed. A self-reported questionnaire was filled to record the tolerance of the three regimens. Results: All three regimens improved the severity of facial signs, skin quality, and skin tone. However, their efficacy was of different extents. In many cases, although the serum provided significant improvements, its combination with HA injection led to slightly greater improvement and in almost all cases, the HA injection alone exhibited a lower efficacy, i.e., 2−3 times smaller in some criteria. Adverse reactions (pain, stinging, tightness etc.) to the HA injection were only recorded 1 h postinjection and were statistically of modest amplitudes. Conclusions: Although limited to a short period and to women presenting modest marks of facial aging (early aging), the study demonstrated that all three regimens showed improvements in several evaluated facial ageing parameters. The combination of the restructuring serum with an HA injection provided an additional benefit compared with HA or serum alone. Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s13555-026-01906-8.
SN - 2193-8210
SN - 2190-9172
ER -