Association of the Pan-Immune-Inflammation Value with Persistent Proteinuria in Patients with Familial Mediterranean Fever
- 1Division of Rheumatology, Department of Internal Medicine, Bursa City Hospital, University of Health Sciences, Bursa 16110, Turkey
- 2Division of Gastroenterology, Department of Internal Medicine, Erzurum Regional Training and Research Hospital, Erzurum 25240, Turkey
- 3Department of Internal Medicine, Bursa City Hospital, University of Health Sciences, Bursa 16110, Turkey
Abstract
Background and Objectives: Persistent proteinuria is an important marker of renal involvement in familial Mediterranean fever (FMF). This study investigated the association between the pan-immune-inflammation value (PIV) and persistent proteinuria, evaluated the discriminatory performance of PIV, the neutrophil-to-lymphocyte ratio (NLR), and monocyte-to-HDL cholesterol ratio (MHR), and identified factors independently associated with persistent proteinuria. Materials and Methods: This retrospective cross-sectional study included 190 adults with FMF and 150 healthy controls. Persistent proteinuria was defined as a spot urine protein-to-creatinine ratio (UPCR) > 20 mg/mmol confirmed on at least two measurements obtained at least 1 week apart. PIV quartile analysis, Spearman correlation, ROC analysis, and multivariable logistic regression were performed. Results: Persistent proteinuria was present in 62 (32.6%) patients with FMF. Its prevalence increased progressively across PIV quartiles (p for trend < 0.001), and PIV was positively correlated with UPCR (ρ = 0.298, p < 0.001). PIV showed an AUC of 0.774, compared with 0.658 for NLR and 0.654 for MHR. In multivariable analysis, PIV (OR 1.006, 95% CI 1.002–1.009, p = 0.001) and homozygous M694V genotype (OR 3.39, 95% CI 1.46–7.86, p = 0.004) were independently associated with persistent proteinuria. Conclusions: PIV and homozygous M694V genotype were independently associated with persistent proteinuria. PIV may serve as an adjunctive biomarker for the assessment of persistent proteinuria in patients with FMF, although prospective multicenter studies are needed to determine its clinical utility.
Related
- Association of body weight change with incident chronic kidney disease in patients with type 2 diabetes without proteinuria: a nationwide cohort study
- Association of finerenone plus tripterygium glycosides with proteinuria reduction in patients with diabetic kidney disease: a retrospective cohort study
- Association of Hemoglobin Level and Diagnostic Delay with Left Atrial Volume Index in Patients with Familial Mediterranean Fever: A Cross-Sectional Observational Study
- Association of preoperative systemic immune-inflammation index and geriatric nutritional risk index with prolonged postoperative length of stay in older patients with hip fracture : A retrospective cohort study
- Association between early intravenous magnesium sulfate administration and mortality according to systemic immune-inflammation index in critically ill patients with acute heart failure: A retrospective cohort study.
BibTeX
@article{gogebakan2026association,
title = {{Association of the Pan-Immune-Inflammation Value with Persistent Proteinuria in Patients with Familial Mediterranean Fever}},
author = {Hasan Göğebakan and Ahmed Ramiz Baykan and Büşra Karadavut and Mekiye Damla Özdemir and Turgut Özdemir and Nizameddin Koca},
journal = {Journal of Clinical Medicine},
year = {2026},
month = oct,
doi = {10.3390/jcm15218459},
url = {https://www.mdpi.com/2077-0383/15/21/8459},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Association of the Pan-Immune-Inflammation Value with Persistent Proteinuria in Patients with Familial Mediterranean Fever
AU - Hasan Göğebakan
AU - Ahmed Ramiz Baykan
AU - Büşra Karadavut
AU - Mekiye Damla Özdemir
AU - Turgut Özdemir
AU - Nizameddin Koca
PY - 2026
DA - 2026/10/30
JO - Journal of Clinical Medicine
DO - 10.3390/jcm15218459
UR - https://www.mdpi.com/2077-0383/15/21/8459
AB - Background and Objectives: Persistent proteinuria is an important marker of renal involvement in familial Mediterranean fever (FMF). This study investigated the association between the pan-immune-inflammation value (PIV) and persistent proteinuria, evaluated the discriminatory performance of PIV, the neutrophil-to-lymphocyte ratio (NLR), and monocyte-to-HDL cholesterol ratio (MHR), and identified factors independently associated with persistent proteinuria. Materials and Methods: This retrospective cross-sectional study included 190 adults with FMF and 150 healthy controls. Persistent proteinuria was defined as a spot urine protein-to-creatinine ratio (UPCR) > 20 mg/mmol confirmed on at least two measurements obtained at least 1 week apart. PIV quartile analysis, Spearman correlation, ROC analysis, and multivariable logistic regression were performed. Results: Persistent proteinuria was present in 62 (32.6%) patients with FMF. Its prevalence increased progressively across PIV quartiles (p for trend < 0.001), and PIV was positively correlated with UPCR (ρ = 0.298, p < 0.001). PIV showed an AUC of 0.774, compared with 0.658 for NLR and 0.654 for MHR. In multivariable analysis, PIV (OR 1.006, 95% CI 1.002–1.009, p = 0.001) and homozygous M694V genotype (OR 3.39, 95% CI 1.46–7.86, p = 0.004) were independently associated with persistent proteinuria. Conclusions: PIV and homozygous M694V genotype were independently associated with persistent proteinuria. PIV may serve as an adjunctive biomarker for the assessment of persistent proteinuria in patients with FMF, although prospective multicenter studies are needed to determine its clinical utility.
SN - 2077-0383
ER -