Levofloxacin-Induced Eosinophilic Pneumonia with Systemic Manifestations: A Case Report and Literature Review

Abstract

Drug-induced eosinophilic pneumonia (D-EP) is a rare adverse drug reaction that can rapidly progress to life-threatening respiratory failure without the timely withdrawal of the offending agent. We herein present the case of a 73-year-old man who developed diffuse erythema, dyspnea, and renal impairment 22 days after the initiation of levofloxacin. Laboratory evaluation revealed marked eosinophilia, and chest CT revealed diffuse ground-glass opacities. His respiratory status deteriorated, thus necessitating noninvasive positive pressure ventilation. Discontinuation of levofloxacin and prompt corticosteroid therapy led to the resolution of the skin lesions, an improvement of the renal function, and recovery, thereby allowing for successful discharge.

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BibTeX RIS

BibTeX

@article{tokunaga2026levofloxacininduced,
  title = {{Levofloxacin-Induced Eosinophilic Pneumonia with Systemic Manifestations: A Case Report and Literature Review}},
  author = {Keigo Tokunaga and Masaru Murasawa and Chisato Yamamura and Masanori Aoyama},
  journal = {Internal Medicine},
  year = {2026},
  month = sep,
  doi = {10.2169/internalmedicine.6404-25},
  url = {https://www.jstage.jst.go.jp/article/internalmedicine/65/18/65_6404-25/_article},
  note = {CC BY-NC-ND},
}

RIS

TY  - JOUR
TI  - Levofloxacin-Induced Eosinophilic Pneumonia with Systemic Manifestations: A Case Report and Literature Review
AU  - Keigo Tokunaga
AU  - Masaru Murasawa
AU  - Chisato Yamamura
AU  - Masanori Aoyama
PY  - 2026
DA  - 2026/09/15
JO  - Internal Medicine
DO  - 10.2169/internalmedicine.6404-25
UR  - https://www.jstage.jst.go.jp/article/internalmedicine/65/18/65_6404-25/_article
AB  - Drug-induced eosinophilic pneumonia (D-EP) is a rare adverse drug reaction that can rapidly progress to life-threatening respiratory failure without the timely withdrawal of the offending agent. We herein present the case of a 73-year-old man who developed diffuse erythema, dyspnea, and renal impairment 22 days after the initiation of levofloxacin. Laboratory evaluation revealed marked eosinophilia, and chest CT revealed diffuse ground-glass opacities. His respiratory status deteriorated, thus necessitating noninvasive positive pressure ventilation. Discontinuation of levofloxacin and prompt corticosteroid therapy led to the resolution of the skin lesions, an improvement of the renal function, and recovery, thereby allowing for successful discharge.
SN  - 1349-7235
SN  - 0918-2918
ER  -

Abstract

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