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Peer-reviewedCC BY-NCInfection and drug resistance

Tropheryma whipplei Pneumonia with Myelofibrosis: A Rare Actinomycetia Case Report and Literature Review.

  • Junbao Liu1
  • Xing Wang1
  • Peitao Xie1
  • Lisen Dong1
  • Pu Bai1
  • Yang Liu1
  • Gang Chen1
  • Duo Hao1
  1. 1Department of Clinical Pharmacy, Ordos Central Hospital, Ordos, 017000, People's Republic of China.
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Abstract

Tropheryma whipplei (T. whipplei) is an uncommon pathogen that infects multiple sites, predominantly the gastrointestinal tract. However, pulmonary involvement is uncommon, and its clinical manifestations and imaging features lack specificity, making it prone to misdiagnosis. However, with the development of metagenomic next-generation sequencing (mNGS), clinicians have a potent tool at their disposal for detecting T. whipplei infections. We report a case of an elderly woman with a history Myelofibrosis who presented with a dry cough, fever, fatigue and difficulty breathing. Routine microbiological tests were negative; mNGS of bronchoalveolar lavage fluid (BALF) suggested T. whipplei infection. Following a definitive diagnosis, the patient was treated with a regimen of meropenem in combination with trimethoprim-sulfamethoxazole (TMP-SMX) for 16 days followed by 2 weeks of TMP-SMX maintenance, after which the patient improved and was discharged uneventfully.

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Cite

BibTeXRIS
BibTeX
@article{liu2026tropheryma,
  title = {{Tropheryma whipplei Pneumonia with Myelofibrosis: A Rare Actinomycetia Case Report and Literature Review.}},
  author = {Junbao Liu and Xing Wang and Peitao Xie and Lisen Dong and Pu Bai and Yang Liu and Gang Chen and Duo Hao},
  journal = {Infection and drug resistance},
  year = {2026},
  month = oct,
  doi = {10.2147/idr.s636054},
  url = {https://europepmc.org/article/MED/42928761},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Tropheryma whipplei Pneumonia with Myelofibrosis: A Rare Actinomycetia Case Report and Literature Review.
AU  - Junbao Liu
AU  - Xing Wang
AU  - Peitao Xie
AU  - Lisen Dong
AU  - Pu Bai
AU  - Yang Liu
AU  - Gang Chen
AU  - Duo Hao
PY  - 2026
DA  - 2026/10/21
JO  - Infection and drug resistance
DO  - 10.2147/idr.s636054
UR  - https://europepmc.org/article/MED/42928761
AB  - Tropheryma whipplei (T. whipplei) is an uncommon pathogen that infects multiple sites, predominantly the gastrointestinal tract. However, pulmonary involvement is uncommon, and its clinical manifestations and imaging features lack specificity, making it prone to misdiagnosis. However, with the development of metagenomic next-generation sequencing (mNGS), clinicians have a potent tool at their disposal for detecting T. whipplei infections. We report a case of an elderly woman with a history Myelofibrosis who presented with a dry cough, fever, fatigue and difficulty breathing. Routine microbiological tests were negative; mNGS of bronchoalveolar lavage fluid (BALF) suggested T. whipplei infection. Following a definitive diagnosis, the patient was treated with a regimen of meropenem in combination with trimethoprim-sulfamethoxazole (TMP-SMX) for 16 days followed by 2 weeks of TMP-SMX maintenance, after which the patient improved and was discharged uneventfully.
SN  - 1178-6973
ER  -