Skip to content
DraconiticResearch
Search Sources API
197,783 studies31 sourcesUpdated 42 min ago
Peer-reviewedCC BYAmerican journal of physiology. Cell physiology

Piezo1 Activation by Yoda1 Inhibits Mechanosensitive ATP Release in Human Urothelial Cells and Bladder Overactivity in Rats with Bladder Outlet Obstruction

  • Shingo Kimura1,2
  • Kanako Matsuoka1
  • Ádám Lénárt3
  • Stephanie L Daugherty3
  • Akihiro Ito2
  • Anne Robertson4
  • Naoki Yoshimura1,3
  • Jonathan M. Beckel3
4 affiliations
  1. 1Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
  2. 2Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan
  3. 3Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
  4. 4Department of Mechanical Engineering and Materials Science, University of Pittsburgh Swanson School of Engineering, Pittsburgh, PA, USA
Read full textDOICite

Abstract

Pharmacological activation of Piezo1 by Yoda1 suppresses mechanosensitive urothelial ATP release through Ca 2+ -dependent connexin hemichannel closure and Ca 2+ -independent mechanisms. In BOO rats, intravesical Yoda1 reduces elevated ATP levels and attenuates bladder overactivity without impairing voiding function, identifying Piezo1 as a novel therapeutic target for BOO-induced lower urinary tract dysfunction.

Related

  1. Astaxanthin Inhibits ox-LDL-Induced Early Endothelial Progenitor Cells Oxidative Stress and Apoptosis Through Nrf2 Activation.
    Keqing Pan, Xiao Xu, Qijun Jiang +4
    Stem cells internationalPeer-reviewedCC BYFull textMolecular biology & gene regulationEurope PMCPMC
  2. When do bacterial mechanosensitive channels get activated?
    S. S. S B, O. Albarran, R. Garces +3
    bioRxivPreprintAll rights reservedFull textBiophysicsbioRxiv
  3. Atomic structure and dynamics of the mechanosensitive channel MscL from Escherichia coli by cryo-EM and solid-state NMR
    Taoran Xiao, Alexandra Kovinko, Chaowei Shi +11
    Science AdvancesPeer-reviewedLicence not statedMolecular biology & gene regulationCrossref
  4. USP9X is a mechanosensitive deubiquitinase that controls tumor cell invasiveness and drug response through YAP stabilization
    Pierric Biber, Alexandrine Carminati, Walaa Mohager +10
    Cell ReportsPeer-reviewedCC BY 4.0Full text10 citedGeneral biochemistryCell biologyHAL
  5. The mechanosensitive channel TMEM63B contributes to noxious heat sensation in the dorsal root ganglia
    Chang Ye, Yan-Yu Zang, Gui-Fang Duan +8
    PLOS BiologyPeer-reviewedCC BY 4.0Full textBiophysicsCell biologyPLOSPMC

Cite

BibTeXRIS
BibTeX
@article{kimura2026piezo1,
  title = {{Piezo1 Activation by Yoda1 Inhibits Mechanosensitive ATP Release in Human Urothelial Cells and Bladder Overactivity in Rats with Bladder Outlet Obstruction}},
  author = {Shingo Kimura and Kanako Matsuoka and Ádám Lénárt and Stephanie L Daugherty and Akihiro Ito and Anne Robertson and Naoki Yoshimura and Jonathan M. Beckel},
  journal = {American journal of physiology. Cell physiology},
  year = {2026},
  month = oct,
  doi = {10.1152/ajpcell.00426.2026},
  url = {https://doi.org/10.1152/ajpcell.00426.2026},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Piezo1 Activation by Yoda1 Inhibits Mechanosensitive ATP Release in Human Urothelial Cells and Bladder Overactivity in Rats with Bladder Outlet Obstruction
AU  - Shingo Kimura
AU  - Kanako Matsuoka
AU  - Ádám Lénárt
AU  - Stephanie L Daugherty
AU  - Akihiro Ito
AU  - Anne Robertson
AU  - Naoki Yoshimura
AU  - Jonathan M. Beckel
PY  - 2026
DA  - 2026/10/06
JO  - American journal of physiology. Cell physiology
DO  - 10.1152/ajpcell.00426.2026
UR  - https://doi.org/10.1152/ajpcell.00426.2026
AB  - Pharmacological activation of Piezo1 by Yoda1 suppresses mechanosensitive urothelial ATP release through Ca 2+ -dependent connexin hemichannel closure and Ca 2+ -independent mechanisms. In BOO rats, intravesical Yoda1 reduces elevated ATP levels and attenuates bladder overactivity without impairing voiding function, identifying Piezo1 as a novel therapeutic target for BOO-induced lower urinary tract dysfunction.
SN  - 0363-6143
SN  - 1522-1563
ER  -