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Peer-reviewedCC BYBMC Microbiology

Extracellular vesicles derived from Echinococcus granulosus hydatid cyst fluid may modulate liver fibrosis through 5-HT2B receptor

  • Leyli Zanjirani Farahani1
  • Soheila Rouhani2
  • Fatemeh Mahdavi3
  • Maryam Niyyati2
  • Nasim Eslami4
  • Majid Fasihi Harandi5
  • Hamed Mirjalali6
6 affiliations
  1. 1Student Research Committee, Department of Medical Parasitology and Mycology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences
  2. 2Department of Medical Parasitology and Mycology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences
  3. 3Department of Medical Parasitology and Mycology, school of Medicine, Urmia University of Medical Sciences
  4. 4Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR
  5. 5Research Center for Hydatid Disease in Iran, Department of Parasitology, Afzalipour School of Medicine, Kerman University of Medical Sciences
  6. 6Foodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences
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Abstract

Background Extracellular Vesicles (EVs) play an important role in cell communication, signal transduction, and the modulation of metabolic processes. The current study aimed to evaluate the effects of Echinococcus granulosus hydatid cyst fluid (HCF) and its EVs on serotonin receptors liver cell line. Results The expression level of 5-HT2A receptor gene showed significant increase in EVs and HCF treated cells after 24 h, 1.73 (p < 0.0001) and 1.62 (p = 0.0084), and 48 h, 1.39 (p = 0.0069), 1.66 (p = 0.0034) respectively. A significant decrease in expression of 5-HT2B receptor gene was seen in the EVs and the HCF group during the first 24 h, p < 0.0001 (EVs: -6.33, HCF: -1.84), while this downregulation in EVs-treated cells was decreased after 48 h (-1.94; p < 0.0001). Furthermore, the gene expression of the liver enzymes, aspartate transaminase (AST) and alanine transaminase (ALT), was significantly changed in both HCF and EVs groups. Conclusion The findings indicate that HCF and its EVs may alter serotonin receptors gene expression. These results suggest that HCF and its EVs may modulate the fibrosis pathways through decreasing the expression of 5-HT2B receptor.

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Cite

BibTeXRIS
BibTeX
@article{farahani2026extracellular,
  title = {{Extracellular vesicles derived from Echinococcus granulosus hydatid cyst fluid may modulate liver fibrosis through 5-HT2B receptor}},
  author = {Leyli Zanjirani Farahani and Soheila Rouhani and Fatemeh Mahdavi and Maryam Niyyati and Nasim Eslami and Majid Fasihi Harandi and Hamed Mirjalali},
  journal = {BMC Microbiology},
  year = {2026},
  month = jul,
  doi = {10.1186/s12866-026-05454-1},
  url = {https://doi.org/10.1186/s12866-026-05454-1},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Extracellular vesicles derived from Echinococcus granulosus hydatid cyst fluid may modulate liver fibrosis through 5-HT2B receptor
AU  - Leyli Zanjirani Farahani
AU  - Soheila Rouhani
AU  - Fatemeh Mahdavi
AU  - Maryam Niyyati
AU  - Nasim Eslami
AU  - Majid Fasihi Harandi
AU  - Hamed Mirjalali
PY  - 2026
DA  - 2026/07/01
JO  - BMC Microbiology
DO  - 10.1186/s12866-026-05454-1
UR  - https://doi.org/10.1186/s12866-026-05454-1
AB  - Background Extracellular Vesicles (EVs) play an important role in cell communication, signal transduction, and the modulation of metabolic processes. The current study aimed to evaluate the effects of Echinococcus granulosus hydatid cyst fluid (HCF) and its EVs on serotonin receptors liver cell line. Results The expression level of 5-HT2A receptor gene showed significant increase in EVs and HCF treated cells after 24 h, 1.73 (p < 0.0001) and 1.62 (p = 0.0084), and 48 h, 1.39 (p = 0.0069), 1.66 (p = 0.0034) respectively. A significant decrease in expression of 5-HT2B receptor gene was seen in the EVs and the HCF group during the first 24 h, p < 0.0001 (EVs: -6.33, HCF: -1.84), while this downregulation in EVs-treated cells was decreased after 48 h (-1.94; p < 0.0001). Furthermore, the gene expression of the liver enzymes, aspartate transaminase (AST) and alanine transaminase (ALT), was significantly changed in both HCF and EVs groups. Conclusion The findings indicate that HCF and its EVs may alter serotonin receptors gene expression. These results suggest that HCF and its EVs may modulate the fibrosis pathways through decreasing the expression of 5-HT2B receptor.
SN  - 1471-2180
ER  -