Skip to content
DraconiticResearch
Search Sources API
201,818 studies31 sourcesUpdated 30 min ago
Peer-reviewedCC BY 4.0JCI Insight

Previous malaria exposure attenuates monocyte-driven inflammation and correlates with modulation of the B cell response

  • Maximilian Julius Lautenbach1,2,3
  • Pengjun Xi1,2,3
  • Linn Kleberg1,2,3
  • Alan-Dine Courey-Ghaouzi1,2,3
  • Maia Serene Gower1,2,3
  • Carolina Sousa Silva1,2,3
  • Felicia Chammas1,2,3
  • Anna Färnert1,2,3
  • Christopher Sundling1,2,3
  1. 1Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
  2. 2Department of Infectious Diseases and
  3. 3Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Read full textPDFDOICite

Abstract

Clinical immunity to malaria develops after repeated malaria episodes. In this process, the inflammatory response is modulated to respond less vigorously upon reinfection. Monocytes are a major source of proinflammatory mediators during blood-stage infection and are known to adapt to repeated pathogen exposure. Here, we investigated the effect of previous malaria exposure on monocytes during blood-stage malaria by comparing the response in previously exposed and primary infected individuals. We observed reduced levels of several proinflammatory chemokines in previously exposed individuals, linked to changes in monocytes. Similarly, BAFF levels were lower in these individuals and associated with modulation of monocyte and dendritic cells. This affected the BAFF/BAFF-R axis, crucial for B cell responses, correlating with increasing parasite-specific antibody levels. Collectively, we present insights into how previous malaria exposure shapes monocyte responses during acute malaria and how these, in turn, correlate with modulation of the B cell compartment and humoral immune response.

Related

  1. 1-Methylhistidine attenuates early myocardial inflammation in type 3 cardiorenal syndrome through modulation of the p105/p50 NF-κB axis
    Jiakun Zhang, Qian Wang, Xingyi Tu +3
    Frontiers in PharmacologyPeer-reviewedCC BY 4.0Full textPharmacology & toxicologyCrossrefEurope PMCPMC
  2. “Radiation-Synthesized Gallotannin Hydrogel Attenuates Trisenox-Induced Nephrotoxicity in Rats: miR-223/TXNIP Axis Modulation of Oxidative Stress and Inflammation”
    Omayma A.R. Abo-Zaid, Mostafa A. Farrag, Aya S. R. Shaaban +2
    Biological Trace Element ResearchPeer-reviewedCC BY-NC-ND 4.0Full textGeneral medicinePMC
  3. Tragopogon coelesyriacus Boiss. attenuates ethanol-induced gastric ulcer in vivo: modulation of oxidative stress, inflammation, and apoptosis
    Hanan Ibrahim Alsharif, Mohammad Khaled Abu-Sini, Abdulrahman Ismael +7
    PLOS OnePeer-reviewedCC BY 4.0Full textImmunologyPharmacology & toxicologyPLOS
  4. Pterostilbene attenuates VCD-induced ovarian damage through modulation of oxidative stress, inflammation, apoptosis, and SIRT1/FOXO3a gene expression
    Kawthar Fadhil Abd Al-Hussein, Suzan Yousif Jasim, Ahmed Salim Mahmood
    PharmaciaPeer-reviewedCC BYFull textEpidemiology & public healthDOAJ
  5. Prevalence and Clinical Correlates of Coronary Perivascular Inflammation in an Asymptomatic Adult Primary Prevention Population: An Assessment of the CT-Derived Fat Attenuation Index Score (FAI-Score)
    D. Stan, J. Fu, M. Ngov +1
    medRxivPreprintAll rights reservedFull textCardiovascular medicinemedRxiv

Cite

BibTeXRIS
BibTeX
@article{lautenbach2026previous,
  title = {{Previous malaria exposure attenuates monocyte-driven inflammation and correlates with modulation of the B cell response}},
  author = {Maximilian Julius Lautenbach and Pengjun Xi and Linn Kleberg and Alan-Dine Courey-Ghaouzi and Maia Serene Gower and Carolina Sousa Silva and Felicia Chammas and Anna Färnert and Christopher Sundling},
  journal = {JCI Insight},
  year = {2026},
  month = sep,
  doi = {10.1172/jci.insight.199206},
  url = {https://doi.org/10.1172/jci.insight.199206},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Previous malaria exposure attenuates monocyte-driven inflammation and correlates with modulation of the B cell response
AU  - Maximilian Julius Lautenbach
AU  - Pengjun Xi
AU  - Linn Kleberg
AU  - Alan-Dine Courey-Ghaouzi
AU  - Maia Serene Gower
AU  - Carolina Sousa Silva
AU  - Felicia Chammas
AU  - Anna Färnert
AU  - Christopher Sundling
PY  - 2026
DA  - 2026/09/08
JO  - JCI Insight
DO  - 10.1172/jci.insight.199206
UR  - https://doi.org/10.1172/jci.insight.199206
AB  - Clinical immunity to malaria develops after repeated malaria episodes. In this process, the inflammatory response is modulated to respond less vigorously upon reinfection. Monocytes are a major source of proinflammatory mediators during blood-stage infection and are known to adapt to repeated pathogen exposure. Here, we investigated the effect of previous malaria exposure on monocytes during blood-stage malaria by comparing the response in previously exposed and primary infected individuals. We observed reduced levels of several proinflammatory chemokines in previously exposed individuals, linked to changes in monocytes. Similarly, BAFF levels were lower in these individuals and associated with modulation of monocyte and dendritic cells. This affected the BAFF/BAFF-R axis, crucial for B cell responses, correlating with increasing parasite-specific antibody levels. Collectively, we present insights into how previous malaria exposure shapes monocyte responses during acute malaria and how these, in turn, correlate with modulation of the B cell compartment and humoral immune response.
SN  - 2379-3708
ER  -