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Peer-reviewedCC BY 4.0Cureus

Non-bacterial Thrombotic Endocarditis Presenting as Cardiogenic Shock With Anterior ST Elevation Revealing an Occult Cholangiocarcinoma: A Case Report

  1. 1Department of Cardiovascular Intensive Care, Cliniques Universitaires Saint-Luc, Brussels, BEL
  2. 2Department of Pathology, Cliniques Universitaires Saint-Luc, Brussels, BEL

Abstract

Non-bacterial thrombotic endocarditis (NBTE) associated with cholangiocarcinoma is rare, with only a few case reports described. The diagnosis is usually made after a thrombotic event or stroke. We report the case of a 44-year-old South African woman who presented with cardiogenic shock and ST elevation while receiving rivaroxaban for a recent pulmonary embolism. Autopsy revealed myocardial embolization secondary to NBTE associated with cholangiocarcinoma. This case highlights the value of point-of-care echocardiography in ruling out complications or alternative diagnoses in atypical presentations of acute coronary syndrome. Furthermore, it underscores that, in NBTE, anticoagulation with heparin is the preferred regimen.

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BibTeX
@article{hannesse2026nonbacterial,
  title = {{Non-bacterial Thrombotic Endocarditis Presenting as Cardiogenic Shock With Anterior ST Elevation Revealing an Occult Cholangiocarcinoma: A Case Report}},
  author = {Colin Hannesse and Francesca Chiara Della Casa and Selda Aydin and Pamela Baldin and Anja Kerschen},
  journal = {Cureus},
  year = {2026},
  month = oct,
  doi = {10.7759/cureus.117501},
  url = {https://doi.org/10.7759/cureus.117501},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Non-bacterial Thrombotic Endocarditis Presenting as Cardiogenic Shock With Anterior ST Elevation Revealing an Occult Cholangiocarcinoma: A Case Report
AU  - Colin Hannesse
AU  - Francesca Chiara Della Casa
AU  - Selda Aydin
AU  - Pamela Baldin
AU  - Anja Kerschen
PY  - 2026
DA  - 2026/10/05
JO  - Cureus
DO  - 10.7759/cureus.117501
UR  - https://doi.org/10.7759/cureus.117501
AB  - Non-bacterial thrombotic endocarditis (NBTE) associated with cholangiocarcinoma is rare, with only a few case reports described. The diagnosis is usually made after a thrombotic event or stroke. We report the case of a 44-year-old South African woman who presented with cardiogenic shock and ST elevation while receiving rivaroxaban for a recent pulmonary embolism. Autopsy revealed myocardial embolization secondary to NBTE associated with cholangiocarcinoma. This case highlights the value of point-of-care echocardiography in ruling out complications or alternative diagnoses in atypical presentations of acute coronary syndrome. Furthermore, it underscores that, in NBTE, anticoagulation with heparin is the preferred regimen.
SN  - 2168-8184
ER  -