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Peer-reviewedCC BY-NCJournal of inflammation research

Trends and Frontiers in Stem Cell Research for Sepsis: A Bibliometric Analysis (1990-2025).

  • Kaiming Han1
  • Hui Ding2
  • Haiying Ma1
  • Junbin Li1
  • Yizheng Zu3
  • Rongsheng Han1
  1. 1The Fifth People's Hospital of Qinghai Province, Qinghai Province Cancer Hospital, Xining, Qinghai, People's Republic of China.
  2. 2Wuzhong People's Hospital, Wuzhong, Ningxia Hui Autonomous Region, People's Republic of China.
  3. 3The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Changzhou, Jiangsu, People's Republic of China.
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Abstract

To systematically map the 35-year intellectual evolution of stem cell research in sepsis and identify emerging frontiers for clinical translation. We retrieved 3890 publications (1990-2025) from the Web of Science Core Collection. Multi-dimensional bibliometric analyses, including co-citation networks, keyword bursts, and alluvial flow mapping, were performed using CiteSpace, HistCite, and R to delineate the field's trajectory. Annual publications increased significantly, peaking in 2024, with the USA and China as primary contributors. The research focus has undergone a major paradigm shift: from early "bone marrow transplantation" and hematopoietic reconstitution (1990s-2000s) to the immunomodulatory mechanisms of "mesenchymal stem cells" (2010s). Currently, the field has entered a "cell-free" era, characterized by intense research into "extracellular vesicles" and "exosomes" (2021-2025). Alluvial analysis identified "cancer", "immunotherapy", and "COVID-19" as dominant integrated modules. Notably, the emergence of "guidelines" and "precision care" highlights a growing emphasis on clinical standardization and targeted treatment for sepsis-induced organ failure. This study demonstrates that the frontier of sepsis therapy is moving toward refined, secretome-based biologics. Our findings provide a strategic roadmap for researchers to prioritize high-potential therapeutic targets and for clinicians to design more focused trials, ultimately accelerating the integration of stem cell-derived products into mainstream sepsis management.

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Cite

BibTeXRIS
BibTeX
@article{han2026trends,
  title = {{Trends and Frontiers in Stem Cell Research for Sepsis: A Bibliometric Analysis (1990-2025).}},
  author = {Kaiming Han and Hui Ding and Haiying Ma and Junbin Li and Yizheng Zu and Rongsheng Han},
  journal = {Journal of inflammation research},
  year = {2026},
  month = nov,
  doi = {10.2147/jir.s578516},
  url = {https://europepmc.org/article/MED/42999863},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Trends and Frontiers in Stem Cell Research for Sepsis: A Bibliometric Analysis (1990-2025).
AU  - Kaiming Han
AU  - Hui Ding
AU  - Haiying Ma
AU  - Junbin Li
AU  - Yizheng Zu
AU  - Rongsheng Han
PY  - 2026
DA  - 2026/11/03
JO  - Journal of inflammation research
DO  - 10.2147/jir.s578516
UR  - https://europepmc.org/article/MED/42999863
AB  - To systematically map the 35-year intellectual evolution of stem cell research in sepsis and identify emerging frontiers for clinical translation. We retrieved 3890 publications (1990-2025) from the Web of Science Core Collection. Multi-dimensional bibliometric analyses, including co-citation networks, keyword bursts, and alluvial flow mapping, were performed using CiteSpace, HistCite, and R to delineate the field's trajectory. Annual publications increased significantly, peaking in 2024, with the USA and China as primary contributors. The research focus has undergone a major paradigm shift: from early "bone marrow transplantation" and hematopoietic reconstitution (1990s-2000s) to the immunomodulatory mechanisms of "mesenchymal stem cells" (2010s). Currently, the field has entered a "cell-free" era, characterized by intense research into "extracellular vesicles" and "exosomes" (2021-2025). Alluvial analysis identified "cancer", "immunotherapy", and "COVID-19" as dominant integrated modules. Notably, the emergence of "guidelines" and "precision care" highlights a growing emphasis on clinical standardization and targeted treatment for sepsis-induced organ failure. This study demonstrates that the frontier of sepsis therapy is moving toward refined, secretome-based biologics. Our findings provide a strategic roadmap for researchers to prioritize high-potential therapeutic targets and for clinicians to design more focused trials, ultimately accelerating the integration of stem cell-derived products into mainstream sepsis management.
SN  - 1178-7031
ER  -