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Peer-reviewedCC BYBMC oral health

Attenuation of cyclophosphamide toxicity by protective effects of curcumin in albino rats model.

  • Noura Mohammed Bakr1,2
  • Abeer Abdel Maksoud3
  • Nehad Abdelmawgoud Ahmad4
4 affiliations
  1. 1Faculty of dental medicine for girls, Al-azhar university, Cairo, Egypt.
  2. 2Faculty of Dentistry, Mutah University, El Karak, Jordan.
  3. 3Faculty of dental medicine Fayoum university, Fayoum, Egypt.
  4. 4Faculty of dental medicine for girls, Al-azhar university, Cairo, Egypt. [email protected].
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Abstract

Background

Chemotherapy primarily treats cancer by using drugs to kill cancer cells. Curcumin, a natural adjuvant, shows promise in preventing side effects.Purpose

This study seeks to determine curcumin's protective effect against cyclophosphamide toxicity.Materials and methods

Twenty-one male albino rats were used in this study, divided into three groups of seven. Group I received daily oral saline. Group II was given a single dose of CP (200 mg/kg) after seven days of saline with 0.5% CMC. Group III received CP (200 mg/kg) on day seven following seven days of CUR (30 mg/kg/day). At the experiment's conclusion, the rats were euthanized under anesthesia, and their parotid salivary glands were collected.Results

The control group showed normal architecture. In group II, histological changes included necrosis of serous acini, striated duct, and atrophy of some acini cells. Group III displayed slight improvement in cell architecture. Cytochrome.Conclusion

The study examined Curcumin's role in preventing Cyclophosphamide-induced changes.

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Cite

BibTeXRIS
BibTeX
@article{bakr2026attenuation,
  title = {{Attenuation of cyclophosphamide toxicity by protective effects of curcumin in albino rats model.}},
  author = {Noura Mohammed Bakr and Abeer Abdel Maksoud and Nehad Abdelmawgoud Ahmad},
  journal = {BMC oral health},
  year = {2026},
  month = oct,
  doi = {10.1186/s12903-026-09975-z},
  url = {https://europepmc.org/article/MED/42892685},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Attenuation of cyclophosphamide toxicity by protective effects of curcumin in albino rats model.
AU  - Noura Mohammed Bakr
AU  - Abeer Abdel Maksoud
AU  - Nehad Abdelmawgoud Ahmad
PY  - 2026
DA  - 2026/10/07
JO  - BMC oral health
DO  - 10.1186/s12903-026-09975-z
UR  - https://europepmc.org/article/MED/42892685
AB  - Background  Chemotherapy primarily treats cancer by using drugs to kill cancer cells. Curcumin, a natural adjuvant, shows promise in preventing side effects.Purpose  This study seeks to determine curcumin's protective effect against cyclophosphamide toxicity.Materials and methods  Twenty-one male albino rats were used in this study, divided into three groups of seven. Group I received daily oral saline. Group II was given a single dose of CP (200 mg/kg) after seven days of saline with 0.5% CMC. Group III received CP (200 mg/kg) on day seven following seven days of CUR (30 mg/kg/day). At the experiment's conclusion, the rats were euthanized under anesthesia, and their parotid salivary glands were collected.Results  The control group showed normal architecture. In group II, histological changes included necrosis of serous acini, striated duct, and atrophy of some acini cells. Group III displayed slight improvement in cell architecture. Cytochrome.Conclusion  The study examined Curcumin's role in preventing Cyclophosphamide-induced changes.
SN  - 1472-6831
ER  -