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PreprintCC BY-NCChemRxiv

Mechanochemically Accelerated Defluorosilylation of α-Trifluoromethyl Styrenes

  • Seishu Ochiai1,2
  • Daiki Harano3,2
  • Zhengyu Zhao3,2
  • Norio Shibata3,2
  1. 1Department of Nanopharmaceutical Sciences
  2. 2Nagoya Institute of Technology, Gokiso
  3. 3Department of Life Science and Applied Chemistry
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Abstract

We report a mechanochemical copper-catalyzed defluorosilylation of α-trifluoromethyl styrenes with silylboranes. Mechanical activation dramatically accelerated the C–F bond transformation, reducing the reaction time from 8 h to only 30 min at room temperature while substantially decreasing solvent consumption. The reaction exhibits broad substrate compatibility and scalability, highlighting mechanochemistry as an effective strategy for accelerating selective C–F bond functionalization.

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Cite

BibTeXRIS
BibTeX
@misc{ochiai2026mechanochemically,
  title = {{Mechanochemically Accelerated Defluorosilylation of α-Trifluoromethyl Styrenes}},
  author = {Seishu Ochiai and Daiki Harano and Zhengyu Zhao and Norio Shibata},
  howpublished = {ChemRxiv},
  year = {2026},
  month = oct,
  doi = {10.26434/chemrxiv.15010538/v1},
  url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010538/v1},
  note = {CC BY-NC},
}
RIS
TY  - UNPB
TI  - Mechanochemically Accelerated Defluorosilylation of α-Trifluoromethyl Styrenes
AU  - Seishu Ochiai
AU  - Daiki Harano
AU  - Zhengyu Zhao
AU  - Norio Shibata
PY  - 2026
DA  - 2026/10/15
PB  - ChemRxiv
DO  - 10.26434/chemrxiv.15010538/v1
UR  - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010538/v1
AB  - We report a mechanochemical copper-catalyzed defluorosilylation of α-trifluoromethyl styrenes with silylboranes. Mechanical activation dramatically accelerated the C–F bond transformation, reducing the reaction time from 8 h to only 30 min at room temperature while substantially decreasing solvent consumption. The reaction exhibits broad substrate compatibility and scalability, highlighting mechanochemistry as an effective strategy for accelerating selective C–F bond functionalization.
ER  -