PLoS Computational Biology Issue Image | Vol. 22(9) October 2026
Abstract
Unfolding the memory retrace in hippocampal replay: Hippocampal replay is the reactivation of neural activity patterns associated with past experience during awake rest and sleep. This image shows replay during sharp-wave ripples in a sleeping rat, with neural firing sequences linked to locations on a previously explored environment. Here, we introduce a probabilistic framework based on drift-diffusion dynamics to characterize how the spatial content of replay unfolds over time. Our framework helps clarify debates including replay speed, whether replay follows a random walk, and the strength of sequential activity before spatial experience. These results provide a new lens on the neural processes underlying spatial learning and memory (Wu and Wei, 2026).
Related
BibTeX
@article{anon2026plos,
title = {{PLoS Computational Biology Issue Image | Vol. 22(9) October 2026}},
journal = {PLoS Computational Biology},
year = {2026},
month = oct,
doi = {10.1371/image.pcbi.v22.i09},
url = {https://doi.org/10.1371/image.pcbi.v22.i09},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - PLoS Computational Biology Issue Image | Vol. 22(9) October 2026
PY - 2026
DA - 2026/10/05
JO - PLoS Computational Biology
DO - 10.1371/image.pcbi.v22.i09
UR - https://doi.org/10.1371/image.pcbi.v22.i09
AB - Unfolding the memory retrace in hippocampal replay: Hippocampal replay is the reactivation of neural activity patterns associated with past experience during awake rest and sleep. This image shows replay during sharp-wave ripples in a sleeping rat, with neural firing sequences linked to locations on a previously explored environment. Here, we introduce a probabilistic framework based on drift-diffusion dynamics to characterize how the spatial content of replay unfolds over time. Our framework helps clarify debates including replay speed, whether replay follows a random walk, and the strength of sequential activity before spatial experience. These results provide a new lens on the neural processes underlying spatial learning and memory (Wu and Wei, 2026).
SN - 1553-7358
ER -