Skip to content
DraconiticResearch
Search Sources API
220,595 studies31 sourcesUpdated 55 min ago
Peer-reviewedCC BY-NC 4.0Brain Tumor Research and Treatment

Diffuse Leptomeningeal Glioneuronal Tumor With Peritoneal Seeding After Ventriculoperitoneal Shunt in an Adult Patient: A Case Report

  • Chaejin Lee1
  • Ki-Su Park1
  • Seong-Hyun Park1
  • Mee-seon Kim2
  • Jeong-Hyun Hwang1
  1. 1Department of Neurosurgery, School of Medicine, Kyungpook National University, Daegu, Korea .
  2. 2Department of Pathology, School of Medicine, Kyungpook National University, Daegu, Korea .
Read full textDOICite

Abstract

Diffuse leptomeningeal glioneuronal tumor (DLGNT) is a rare central nervous system neoplasm characterized by diffuse leptomeningeal dissemination and variable molecular alterations. Although predominantly reported in pediatric patients, adult cases have increasingly been described. We report a 28-year-old woman who presented with progressive headache and hydrocephalus accompanied by diffuse leptomeningeal enhancement on MRI. She was initially misdiagnosed with tuberculous meningitis and underwent ventriculoperitoneal (VP) shunt placement. Progressive neurological deterioration led to open biopsy, which revealed oligodendroglial-like tumor cells with positive immunoreactivity for Olig2 and synaptophysin. Molecular analysis identified H3K28M, FGFR1, and ATRX mutations with 1p deletion. The patient received craniospinal irradiation followed by temozolomide chemotherapy, achieving temporary disease stabilization. Fifteen months after diagnosis, she developed massive ascites, and peritoneal biopsy confirmed metastatic dissemination consistent with DLGNT. Despite treatment, she died 18 months after initial diagnosis. This case highlights the diagnostic challenge of adult DLGNT, the molecular heterogeneity of the disease, and the potential risk of peritoneal dissemination following VP shunt placement. Awareness of possible extraneural spread is essential in managing this rare tumor.

Related

  1. Diffuse Leptomeningeal Glioneuronal Tumor With Initial Diagnosis of Pilocytic Astrocytoma With Anaplasia: A Case Study
    Anita Zhou, Joseph Carmicheal, Jie Chen +1
    Clinical case reportsPeer-reviewedCC BY-NC-NDFull textHuman geneticsEurope PMCDOAJ
  2. Case Report: High-grade diffuse leptomeningeal glioneuronal tumor-MC2 in a 6-year-old child with diagnostic delay and short-term complete radiological response after CEV-based chemotherapy
    Wangbin Deng, Guofu Li, Yongkang Zhang
    Frontiers in OncologyPeer-reviewedCC BY 4.0OncologyFrontiersCrossref
  3. MRI Features of Diffuse Glioneuronal Tumor with Oligodendroglioma-like features and Nuclear Clusters: A Case Report and Literature Review
    Dabiao Deng, Chongzhu Fan, Yanying Yang +3
    Current Medical ImagingPeer-reviewedCC BY 4.0Full textOncologyPMC
  4. Delayed Umbilical Extrusion of a Ventriculoperitoneal Shunt Following Robotic-Assisted Laparoscopic Hysterectomy: A Case Report
    Alejandro M Castañer, Amanda Detres, Alejandro E Cedeño-Morán +3
    CureusPeer-reviewedCC BYFull textGeneral medicineEurope PMC
  5. Factors Associated with Ventriculoperitoneal Shunt Placement Following Posterior Fossa Tumor Resection in Children: A Systematic Review and Meta-Analysis
    Younis Al-Mufargi, Asma AlHosni, Ayat Al Zadjali +5
    Medicina (Kaunas, Lithuania)Peer-reviewedCC BYFull textGeneral medicineEurope PMC

Cite

BibTeXRIS
BibTeX
@article{lee2026diffuse,
  title = {{Diffuse Leptomeningeal Glioneuronal Tumor With Peritoneal Seeding After Ventriculoperitoneal Shunt in an Adult Patient: A Case Report}},
  author = {Chaejin Lee and Ki-Su Park and Seong-Hyun Park and Mee-seon Kim and Jeong-Hyun Hwang},
  journal = {Brain Tumor Research and Treatment},
  year = {2026},
  month = aug,
  doi = {10.14791/btrt.2026.0010},
  url = {https://doi.org/10.14791/btrt.2026.0010},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - Diffuse Leptomeningeal Glioneuronal Tumor With Peritoneal Seeding After Ventriculoperitoneal Shunt in an Adult Patient: A Case Report
AU  - Chaejin Lee
AU  - Ki-Su Park
AU  - Seong-Hyun Park
AU  - Mee-seon Kim
AU  - Jeong-Hyun Hwang
PY  - 2026
DA  - 2026/08/07
JO  - Brain Tumor Research and Treatment
DO  - 10.14791/btrt.2026.0010
UR  - https://doi.org/10.14791/btrt.2026.0010
AB  - Diffuse leptomeningeal glioneuronal tumor (DLGNT) is a rare central nervous system neoplasm characterized by diffuse leptomeningeal dissemination and variable molecular alterations. Although predominantly reported in pediatric patients, adult cases have increasingly been described. We report a 28-year-old woman who presented with progressive headache and hydrocephalus accompanied by diffuse leptomeningeal enhancement on MRI. She was initially misdiagnosed with tuberculous meningitis and underwent ventriculoperitoneal (VP) shunt placement. Progressive neurological deterioration led to open biopsy, which revealed oligodendroglial-like tumor cells with positive immunoreactivity for Olig2 and synaptophysin. Molecular analysis identified H3K28M, FGFR1, and ATRX mutations with 1p deletion. The patient received craniospinal irradiation followed by temozolomide chemotherapy, achieving temporary disease stabilization. Fifteen months after diagnosis, she developed massive ascites, and peritoneal biopsy confirmed metastatic dissemination consistent with DLGNT. Despite treatment, she died 18 months after initial diagnosis. This case highlights the diagnostic challenge of adult DLGNT, the molecular heterogeneity of the disease, and the potential risk of peritoneal dissemination following VP shunt placement. Awareness of possible extraneural spread is essential in managing this rare tumor.
SN  - 2288-2405
SN  - 2288-2413
ER  -