Exploratory evaluation of a CEUS-derived substitution for solid-component measurement in the ADNEX model.
11 affiliations
- 1Department of Ultrasound, the Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou, Guangdong, 510630, People's Republic of China.
- 2Department of Ultrasound, Henan Provincial People's Hospital, Zhengzhou, People's Republic of China.
- 3Department of Ultrasound, The Third Hospital of BaoGang Group, The Maternity Hospital of Bao Tou, Baotou, People's Republic of China.
- 4Department of Ultrasound, Huizhou Central People's Hospital, Huizhou, People's Republic of China.
- 5Department of Ultrasound, Children's Hospital of Shanxi (Women's Health Center of Shanxi), Taiyuan, People's Republic of China.
- 6Ultrasound Diagnosis Center, Shaanxi Provincial People's Hospital, Xian, People's Republic of China.
- 7Department of Ultrasound, The Fifth People's Hospital of Chengdu, Chengdu, People's Republic of China.
- 8Department of Ultrasound Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, People's Republic of China.
- 9Department of Ultrasound, Nanchong Central Hospital, Nanchong, People's Republic of China.
- 10Department of Ultrasound, Wuhan Central Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 26 Shengli Street, Jiang'an District, Wuhan, 430014, People's Republic of China. [email protected].
- 11Department of Ultrasound, the Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou, Guangdong, 510630, People's Republic of China. [email protected].
Abstract
Background
Although the Assessment of Different Neoplasias in the adnexa (ADNEX) model has been widely validated, there remains challenges in differentiating true solid components from benign mimics. We aimed to evaluate the feasibility and value of substituting conventional ultrasound-derived solid component size with CEUS-derived measurements in the ADNEX model for adnexal lesions discrimination.Methods
This multicenter prospective study recruited consecutive patients with suspected adnexal lesions with solid components detected at ultrasound between January 2022 and June 2024. All patients underwent preoperative CEUS examination. Pathological results serve as the reference standard. Each adnexal lesion was evaluated using ADNEX, a CEUS-based modified ADNEX score (CEUS-derived substitution for solid-component measurement without updating model coefficients) and Ovarian-Adnexal Reporting and Data System (O-RADS) Ultrasound (US) score.Results
A total of 204 patients (median age, 47.0 years [IQR: 33.0-56.0 years]) with 204 lesions were included. The area under the receiver operating characteristic curve (AUROC) for CEUS-based modified ADNEX was 0.906 (95% CI: 0.867-0.944), which was superior to that of ADNEX (AUROC:0.865; 95% CI, 0.814-0.916; P = 0.019) and O-RADS US (AUROC: 0.783; 95% CI, 0.726 -0.840; P < 0.001) in classifying adnexal lesions with solid components. CEUS-based modified ADNEX demonstrated greater specificity (0.664) compared to ADNEX (0.283; P < 0.001) and O-RADS US (0.221; P < 0.001).Conclusions
CEUS-derived modification for solid-component measurement in the ADNEX model showed potential improvements in the diagnostic specificity and clinical benefit compared with the original ADNEX framework in the classification of adnexal lesions with solid components.
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BibTeX
@article{wu2026exploratory,
title = {{Exploratory evaluation of a CEUS-derived substitution for solid-component measurement in the ADNEX model.}},
author = {Manli Wu and Ying Chen and Shuangyu Wu and Ruili Wang and Xiaotao Meng and Hong Wen and Rui Zhang and Liang Mu and Li Xiao and Tingting Liu and Sijia Chen and Zeping Huang and Junlin Zhong and Yatong Chen and Ying Wang and Man Zhang and Licong Huang and Jingjing Liu and Xiaofeng Sun and Xinling Zhang},
journal = {BMC women's health},
year = {2026},
month = jul,
doi = {10.1186/s12905-026-04700-y},
url = {https://europepmc.org/article/MED/42902302},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Exploratory evaluation of a CEUS-derived substitution for solid-component measurement in the ADNEX model.
AU - Manli Wu
AU - Ying Chen
AU - Shuangyu Wu
AU - Ruili Wang
AU - Xiaotao Meng
AU - Hong Wen
AU - Rui Zhang
AU - Liang Mu
AU - Li Xiao
AU - Tingting Liu
AU - Sijia Chen
AU - Zeping Huang
AU - Junlin Zhong
AU - Yatong Chen
AU - Ying Wang
AU - Man Zhang
AU - Licong Huang
AU - Jingjing Liu
AU - Xiaofeng Sun
AU - Xinling Zhang
PY - 2026
DA - 2026/07/01
JO - BMC women's health
DO - 10.1186/s12905-026-04700-y
UR - https://europepmc.org/article/MED/42902302
AB - Background Although the Assessment of Different Neoplasias in the adnexa (ADNEX) model has been widely validated, there remains challenges in differentiating true solid components from benign mimics. We aimed to evaluate the feasibility and value of substituting conventional ultrasound-derived solid component size with CEUS-derived measurements in the ADNEX model for adnexal lesions discrimination.Methods This multicenter prospective study recruited consecutive patients with suspected adnexal lesions with solid components detected at ultrasound between January 2022 and June 2024. All patients underwent preoperative CEUS examination. Pathological results serve as the reference standard. Each adnexal lesion was evaluated using ADNEX, a CEUS-based modified ADNEX score (CEUS-derived substitution for solid-component measurement without updating model coefficients) and Ovarian-Adnexal Reporting and Data System (O-RADS) Ultrasound (US) score.Results A total of 204 patients (median age, 47.0 years [IQR: 33.0-56.0 years]) with 204 lesions were included. The area under the receiver operating characteristic curve (AUROC) for CEUS-based modified ADNEX was 0.906 (95% CI: 0.867-0.944), which was superior to that of ADNEX (AUROC:0.865; 95% CI, 0.814-0.916; P = 0.019) and O-RADS US (AUROC: 0.783; 95% CI, 0.726 -0.840; P < 0.001) in classifying adnexal lesions with solid components. CEUS-based modified ADNEX demonstrated greater specificity (0.664) compared to ADNEX (0.283; P < 0.001) and O-RADS US (0.221; P < 0.001).Conclusions CEUS-derived modification for solid-component measurement in the ADNEX model showed potential improvements in the diagnostic specificity and clinical benefit compared with the original ADNEX framework in the classification of adnexal lesions with solid components.
SN - 1472-6874
ER -