Dual-Crosslinked Gelatin/Chondroitin Sulfate Hydrogel Loaded with Curcumin Liposomes for Multifunctional Wound Dressing
- 1Faculty of Light Industry, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China
- 2Food Resources Development and Health Product Creation International Joint Laboratory, Innovation Center for High-Value Development and Utilization of Bio-Health Food Technology of Shandong Province, Heze Branch of Qilu University of Technology (Shandong Academy of Sciences), Heze 274000, China
- 3State Key Laboratory of Green Papermaking and Resource Recycling, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China
Abstract
Despite the widespread use of gelatin (Gel) in wound dressings due to its biocompatibility, biodegradability, and intrinsic bioactivity, it remains challenging to simultaneously achieve robust mechanical properties and multiple biofunctions in a single hydrogel system. Herein, we constructed a Gel/oxidized chondroitin sulfate (OCS) dynamic Schiff-base network and further introduced triglycidylamine (TGA) as a covalent crosslinker, yielding a Gel/OCS/TGA hydrogel with a proposed dynamic/covalent dual-crosslinked structure. Curcumin liposomes (Cur@Lipo), prepared using microfluidic technology, were then incorporated as bioactive nanofillers to obtain the multifunctional Gel/OCS/TGA/Cur@Lipo composite hydrogel. The hydrogel exhibited self-healing and injectable behavior, which may be associated with the reversible dynamic bonds present in the network. By adjusting the TGA content, the composite hydrogel achieved a tensile strength of 315 kPa, an elongation at break of 258%, and a compressive stress of 72 kPa at 60% strain. Moreover, the hydrogel exhibited sustained curcumin release, marked antioxidant activity (DPPH and ABTS radical scavenging rates of 59.8% and 83.98%, respectively), and antibacterial activity against E. coli and S. aureus (>99.99%), while maintaining good cytocompatibility. In summary, Gel/OCS/TGA/Cur@Lipo multifunctional composite hydrogel is a promising candidate for wound dressing applications, although further in vivo studies are required to confirm its clinical applicability.
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BibTeX
@article{han2026dualcrosslinked,
title = {{Dual-Crosslinked Gelatin/Chondroitin Sulfate Hydrogel Loaded with Curcumin Liposomes for Multifunctional Wound Dressing}},
author = {Jiatong Han and Pengfei Qiao and Daijie Wang and Hao Li and Liqiang Jin and Qinghua Xu},
journal = {Molecules},
year = {2026},
month = oct,
doi = {10.3390/molecules31213868},
url = {https://www.mdpi.com/1420-3049/31/21/3868},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Dual-Crosslinked Gelatin/Chondroitin Sulfate Hydrogel Loaded with Curcumin Liposomes for Multifunctional Wound Dressing
AU - Jiatong Han
AU - Pengfei Qiao
AU - Daijie Wang
AU - Hao Li
AU - Liqiang Jin
AU - Qinghua Xu
PY - 2026
DA - 2026/10/27
JO - Molecules
DO - 10.3390/molecules31213868
UR - https://www.mdpi.com/1420-3049/31/21/3868
AB - Despite the widespread use of gelatin (Gel) in wound dressings due to its biocompatibility, biodegradability, and intrinsic bioactivity, it remains challenging to simultaneously achieve robust mechanical properties and multiple biofunctions in a single hydrogel system. Herein, we constructed a Gel/oxidized chondroitin sulfate (OCS) dynamic Schiff-base network and further introduced triglycidylamine (TGA) as a covalent crosslinker, yielding a Gel/OCS/TGA hydrogel with a proposed dynamic/covalent dual-crosslinked structure. Curcumin liposomes (Cur@Lipo), prepared using microfluidic technology, were then incorporated as bioactive nanofillers to obtain the multifunctional Gel/OCS/TGA/Cur@Lipo composite hydrogel. The hydrogel exhibited self-healing and injectable behavior, which may be associated with the reversible dynamic bonds present in the network. By adjusting the TGA content, the composite hydrogel achieved a tensile strength of 315 kPa, an elongation at break of 258%, and a compressive stress of 72 kPa at 60% strain. Moreover, the hydrogel exhibited sustained curcumin release, marked antioxidant activity (DPPH and ABTS radical scavenging rates of 59.8% and 83.98%, respectively), and antibacterial activity against E. coli and S. aureus (>99.99%), while maintaining good cytocompatibility. In summary, Gel/OCS/TGA/Cur@Lipo multifunctional composite hydrogel is a promising candidate for wound dressing applications, although further in vivo studies are required to confirm its clinical applicability.
SN - 1420-3049
ER -