NIR-responsive carbon monoxide nanoplatform for synergistic antibacterial and anti-inflammatory therapy of refractory keratitis and biofilm-infected wounds
4 affiliations
- 1Zhejiang University, Eye Center of Second Affiliated Hospital, School of Medicine, Hangzhou, 310009, China; Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, 310009, China
- 2Zhejiang Cancer Hospital, Zhejiang Key Laboratory of Functional Nucleic Acids for Basic and Clinical Application, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, 310022, China; School of Molecular Medicine, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China
- 3Zhejiang University, Eye Center of Second Affiliated Hospital, School of Medicine, Hangzhou, 310009, China; Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, 310009, China; Corresponding author.
- 4Zhejiang Cancer Hospital, Zhejiang Key Laboratory of Functional Nucleic Acids for Basic and Clinical Application, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, 310022, China; Corresponding author.
Abstract
Drug-resistant bacterial biofilms hinder the treatment of persistent infections by limiting drug penetration and reducing bacterial susceptibility through their dense extracellular matrix and active signaling networks. Herein, we developed a near-infrared (NIR) light-responsive, bacteria-targeting nanoplatform, termed UCMSP-CL, for localized carbon monoxide (CO) delivery and biofilm eradication. UCMSP-CL disrupts biofilm architecture and adheres to bacteria through electrostatic interactions and enzyme-substrate recognition. Subsequent NIR irradiation triggers local CO release, which induces severe bacterial metabolic exhaustion by inhibiting the bacterial respiratory chain, depleting ATP and compromising membrane integrity, while exerting potent anti-inflammatory effects. In murine models of methicillin-resistant Staphylococcus aureus (MRSA) keratitis and infected skin wounds, NIR-irradiated UCMSP-CL markedly reduced bacterial burden, promoted biofilm clearance, alleviated local inflammation, and accelerated tissue repair. These findings establish a controllable platform that couples antibacterial and anti-inflammatory activities, offering a potential strategy for treating biofilm-associated and drug-resistant infections.
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BibTeX
@article{han2026nirresponsive,
title = {{NIR-responsive carbon monoxide nanoplatform for synergistic antibacterial and anti-inflammatory therapy of refractory keratitis and biofilm-infected wounds}},
author = {Yuqi Han and Kai Deng and Ruoqi Chen and Fuyao Chen and Ke Yao and Yang Ye and Zhen Du and Xingchao Shentu},
journal = {Materials Today Bio},
year = {2026},
month = oct,
doi = {10.1016/j.mtbio.2026.103727},
url = {https://doi.org/10.1016/j.mtbio.2026.103727},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - NIR-responsive carbon monoxide nanoplatform for synergistic antibacterial and anti-inflammatory therapy of refractory keratitis and biofilm-infected wounds
AU - Yuqi Han
AU - Kai Deng
AU - Ruoqi Chen
AU - Fuyao Chen
AU - Ke Yao
AU - Yang Ye
AU - Zhen Du
AU - Xingchao Shentu
PY - 2026
DA - 2026/10/05
JO - Materials Today Bio
DO - 10.1016/j.mtbio.2026.103727
UR - https://doi.org/10.1016/j.mtbio.2026.103727
AB - Drug-resistant bacterial biofilms hinder the treatment of persistent infections by limiting drug penetration and reducing bacterial susceptibility through their dense extracellular matrix and active signaling networks. Herein, we developed a near-infrared (NIR) light-responsive, bacteria-targeting nanoplatform, termed UCMSP-CL, for localized carbon monoxide (CO) delivery and biofilm eradication. UCMSP-CL disrupts biofilm architecture and adheres to bacteria through electrostatic interactions and enzyme-substrate recognition. Subsequent NIR irradiation triggers local CO release, which induces severe bacterial metabolic exhaustion by inhibiting the bacterial respiratory chain, depleting ATP and compromising membrane integrity, while exerting potent anti-inflammatory effects. In murine models of methicillin-resistant Staphylococcus aureus (MRSA) keratitis and infected skin wounds, NIR-irradiated UCMSP-CL markedly reduced bacterial burden, promoted biofilm clearance, alleviated local inflammation, and accelerated tissue repair. These findings establish a controllable platform that couples antibacterial and anti-inflammatory activities, offering a potential strategy for treating biofilm-associated and drug-resistant infections.
SN - 2590-0064
ER -