Thermodynamically-driven the transformation of supramolecular morphology and nanoscale accompanied with the toxic changes from herbal medicine
- 1School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 102488, China
- 2National Institute of Traditional Chinese Medicine Constitution and Preventive Treatment of Diseases, Beijing University of Chinese Medicine, Beijing, 100105, China; Corresponding author.
- 3School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 102488, China; Corresponding author.
Abstract
Biological function and risk coexisted in the vigorous development of nanomedicine. Its toxic accumulation risk in the human body and other health hazards also made people increasingly worried about its safety risk. In this study, the micro-morphology of multi-component self-assembly in Rhei Radix et Rhizoma (RR)- Coptidis Rhizoma (CR) were regulated by thermodynamic method to realize the difference of diarrhea effect. The nano-morphology of the decoction was transformed from fiber network (cold mixing decoction (CM)) to spherical particles (hot mix reheating decoction (HMR)) by reheating treatment. This morphological transformation was achieved by altering the arrangement of key components such as emodin (Emo) and berberine (Ber) from a staggered assembly to a face-to-face assembly, which increased the interaction area and interaction force. The fiber network in CM exhibited indiscriminate coverage, causing severe damage to intestinal probiotics. This disruption promoted tyrosine metabolism of Enterobacteriaceae, resulting in large area proliferation of pathogenic bacteria and subsequent diarrhea. In contrast, the spheroid particles of HMR selectively attached to bacteria, thereby reducing toxicity to intestinal bacteria. By promoting tryptophan metabolism, intestinal homeostasis and intestinal barrier of HMR were maintained to prevent the toxic of diarrhea. This study provides a novel strategy for the toxic study of nanomedicine and offers reference for rational use of nanomedicine in clinic.
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BibTeX
@article{lin2026thermodynamicallydriven,
title = {{Thermodynamically-driven the transformation of supramolecular morphology and nanoscale accompanied with the toxic changes from herbal medicine}},
author = {Xiaoyu Lin and Jichang Wei and Yihang Zhao and Liuyang Zhang and Ji Wang and Xuemei Huang and Penglong Wang},
journal = {Journal of Pharmaceutical Analysis},
year = {2026},
month = oct,
doi = {10.1016/j.jpha.2026.101650},
url = {https://doi.org/10.1016/j.jpha.2026.101650},
note = {CC BY},
}
RIS
TY - JOUR
TI - Thermodynamically-driven the transformation of supramolecular morphology and nanoscale accompanied with the toxic changes from herbal medicine
AU - Xiaoyu Lin
AU - Jichang Wei
AU - Yihang Zhao
AU - Liuyang Zhang
AU - Ji Wang
AU - Xuemei Huang
AU - Penglong Wang
PY - 2026
DA - 2026/10/28
JO - Journal of Pharmaceutical Analysis
DO - 10.1016/j.jpha.2026.101650
UR - https://doi.org/10.1016/j.jpha.2026.101650
AB - Biological function and risk coexisted in the vigorous development of nanomedicine. Its toxic accumulation risk in the human body and other health hazards also made people increasingly worried about its safety risk. In this study, the micro-morphology of multi-component self-assembly in Rhei Radix et Rhizoma (RR)- Coptidis Rhizoma (CR) were regulated by thermodynamic method to realize the difference of diarrhea effect. The nano-morphology of the decoction was transformed from fiber network (cold mixing decoction (CM)) to spherical particles (hot mix reheating decoction (HMR)) by reheating treatment. This morphological transformation was achieved by altering the arrangement of key components such as emodin (Emo) and berberine (Ber) from a staggered assembly to a face-to-face assembly, which increased the interaction area and interaction force. The fiber network in CM exhibited indiscriminate coverage, causing severe damage to intestinal probiotics. This disruption promoted tyrosine metabolism of Enterobacteriaceae, resulting in large area proliferation of pathogenic bacteria and subsequent diarrhea. In contrast, the spheroid particles of HMR selectively attached to bacteria, thereby reducing toxicity to intestinal bacteria. By promoting tryptophan metabolism, intestinal homeostasis and intestinal barrier of HMR were maintained to prevent the toxic of diarrhea. This study provides a novel strategy for the toxic study of nanomedicine and offers reference for rational use of nanomedicine in clinic.
SN - 2095-1779
SN - 2214-0883
ER -