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Peer-reviewedCC BY-NCInternational Journal of Molecular and Cellular Medicine

Role of MicroRNAs in regulating NF-kB Inflammatory pathways During Dental Implant Osseointegration

  • Ghazal Soleimani1
  • Pouria Farahani2
  • Ailar Yousefbeigi3
  • Diyako Farajpur4
  • Paria Amooyan5
  • Asieh Mozaffari6
  • mina aghabeigi7
7 affiliations
  1. 1Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  2. 2Faculty of Dentistry, Dental Surgery Shahid beheshti University of Medical science, ,Tehran, Iran.
  3. 3International Dentist Program, School of Dentistry, University of California, Los Angeles (UCLA), Los Angeles, California, United States of America
  4. 4Faculty of Dentistry, kermanshah university of medical sciences, Kermanshah, Iran.
  5. 5Department of Endodontics, Faculty of Dentistry, Shahed University, Tehran, Iran.
  6. 6Department of Periodontics, Faculty of Dentistry, Qazvin University of Medical Sciences, Qazvin, Iran.
  7. 7Department of Periodontology, School of Dentistry, Ahvaz Jundishapur University of Medical Sciences, Ahwaz, Iran
PDFCite

Abstract

The process of osseointegration for dental implants is complex and can be influenced by localized inflammation. The NF-κB signaling system plays a crucial role in regulating inflammatory responses. This review examines the role of microRNAs (miRNAs) in regulating the NF-κB pathway in inflammatory conditions associated with dental implants, including periodontitis, alveolar bone abnormalities, and estrogen deficiency models. A review of prior research demonstrates that miRNAs, specifically miR-146a, miR-21a-5p, miR-182, and miR-100-5p, modulate NF-κB activation and maintain the balance between osteogenesis and osteoclastogenesis by targeting molecules such as FoxO1, TLR4, and PDCD4. These interactions lead to a reduction in reactive oxygen species, inhibition of pro-inflammatory cytokines (including IL-1β and TNF-α), and an elevation in osteogenic markers (such as Runx2 and ALP). The findings indicate that the miRNA-NF-κB axes can lead to peri-implantitis and implant failure. On the other hand, miRNA-based therapeutics, such as agomirs and antagomirs, might assist in improving osseointegration outcomes. This study highlights the importance of miRNAs in modulating NF-κB inflammation for the effectiveness of dental implants and suggests avenues for further research.

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Cite

BibTeXRIS
BibTeX
@article{soleimani2026role,
  title = {{Role of MicroRNAs in regulating NF-kB Inflammatory pathways During Dental Implant Osseointegration}},
  author = {Ghazal Soleimani and Pouria Farahani and Ailar Yousefbeigi and Diyako Farajpur and Paria Amooyan and Asieh Mozaffari and mina aghabeigi},
  journal = {International Journal of Molecular and Cellular Medicine},
  year = {2026},
  month = jun,
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Role of MicroRNAs in regulating NF-kB Inflammatory pathways During Dental Implant Osseointegration
AU  - Ghazal Soleimani
AU  - Pouria Farahani
AU  - Ailar Yousefbeigi
AU  - Diyako Farajpur
AU  - Paria Amooyan
AU  - Asieh Mozaffari
AU  - mina aghabeigi
PY  - 2026
DA  - 2026/06/01
JO  - International Journal of Molecular and Cellular Medicine
AB  - The process of osseointegration for dental implants is complex and can be influenced by localized inflammation. The NF-κB signaling system plays a crucial role in regulating inflammatory responses. This review examines the role of microRNAs (miRNAs) in regulating the NF-κB pathway in inflammatory conditions associated with dental implants, including periodontitis, alveolar bone abnormalities, and estrogen deficiency models. A review of prior research demonstrates that miRNAs, specifically miR-146a, miR-21a-5p, miR-182, and miR-100-5p, modulate NF-κB activation and maintain the balance between osteogenesis and osteoclastogenesis by targeting molecules such as FoxO1, TLR4, and PDCD4. These interactions lead to a reduction in reactive oxygen species, inhibition of pro-inflammatory cytokines (including IL-1β and TNF-α), and an elevation in osteogenic markers (such as Runx2 and ALP). The findings indicate that the miRNA-NF-κB axes can lead to peri-implantitis and implant failure. On the other hand, miRNA-based therapeutics, such as agomirs and antagomirs, might assist in improving osseointegration outcomes. This study highlights the importance of miRNAs in modulating NF-κB inflammation for the effectiveness of dental implants and suggests avenues for further research.
SN  - 2251-9637
SN  - 2251-9645
ER  -