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Peer-reviewedCC BY-NC-NDChemistry & biodiversity

Comparative Enzyme Inhibitory and Antioxidant Activities of Selected Turkish Medicinal Plants With LC-MS/MS Profiling of Morus nigra Extract.

  • Sultan Pekacar1
  • Burçin Özüpek1
  • Semih Bulut2
  • Mustafa Abdullah Yilmaz3,4
  • Oğuz Çakir3,5
  • Abbas Tarhan3
  • Osman Tugay6
  • Didem Deliorman Orhan1
6 affiliations
  1. 1Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Ankara, Türkiye.
  2. 2Department of Pharmacognosy, Faculty of Pharmacy, Süleyman Demirel University, Isparta, Türkiye.
  3. 3Dicle University Science and Technology Research and Application Center, Diyarbakır, Türkiye.
  4. 4Department of Analytical Chemistry, Faculty of Pharmacy, Dicle University, Diyarbakır, Türkiye.
  5. 5Department of Nutrition and Dietetics, Faculty of Health Sciences, Dicle University, Diyarbakır, Türkiye.
  6. 6Department of Pharmaceutical Botany, Faculty of Pharmacy, Selçuk University, Konya, Türkiye.
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Abstract

The enzyme inhibitory and antioxidant activities of eight medicinal plants from Türkiye were investigated in vitro. Extracts were evaluated for their inhibitory effects on α-glucosidase, α-amylase, pancreatic lipase, and pancreatic cholesterol esterase, together with antioxidant properties using DPPH radical scavenging, metal chelation, and ferric-reducing power assays. Among the tested samples, Morus nigra extract exhibited the strongest α-glucosidase inhibition (IC₅₀ = 43.34 ± 1.76 µg/mL) and showed moderate activity against pancreatic lipase and α-amylase. LC-MS/MS analysis of the 80% ethanol extract of M. nigra led to the identification of 22 phenolic compounds, with quinic acid as the major compound, followed by isoquercitrin and chlorogenic acid. The observed bioactivities may be attributed to the combined effects of these phenolic compounds. These findings suggest that M. nigra may serve as a promising natural source of phenolic compounds with potential inhibitory activity against enzymes associated with metabolic disorders.

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Cite

BibTeXRIS
BibTeX
@article{pekacar2026comparative,
  title = {{Comparative Enzyme Inhibitory and Antioxidant Activities of Selected Turkish Medicinal Plants With LC-MS/MS Profiling of Morus nigra Extract.}},
  author = {Sultan Pekacar and Burçin Özüpek and Semih Bulut and Mustafa Abdullah Yilmaz and Oğuz Çakir and Abbas Tarhan and Osman Tugay and Didem Deliorman Orhan},
  journal = {Chemistry \& biodiversity},
  year = {2026},
  month = oct,
  doi = {10.1002/cbdv.71852},
  url = {https://europepmc.org/article/MED/42904773},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Comparative Enzyme Inhibitory and Antioxidant Activities of Selected Turkish Medicinal Plants With LC-MS/MS Profiling of Morus nigra Extract.
AU  - Sultan Pekacar
AU  - Burçin Özüpek
AU  - Semih Bulut
AU  - Mustafa Abdullah Yilmaz
AU  - Oğuz Çakir
AU  - Abbas Tarhan
AU  - Osman Tugay
AU  - Didem Deliorman Orhan
PY  - 2026
DA  - 2026/10/01
JO  - Chemistry & biodiversity
DO  - 10.1002/cbdv.71852
UR  - https://europepmc.org/article/MED/42904773
AB  - The enzyme inhibitory and antioxidant activities of eight medicinal plants from Türkiye were investigated in vitro. Extracts were evaluated for their inhibitory effects on α-glucosidase, α-amylase, pancreatic lipase, and pancreatic cholesterol esterase, together with antioxidant properties using DPPH radical scavenging, metal chelation, and ferric-reducing power assays. Among the tested samples, Morus nigra extract exhibited the strongest α-glucosidase inhibition (IC₅₀ = 43.34 ± 1.76 µg/mL) and showed moderate activity against pancreatic lipase and α-amylase. LC-MS/MS analysis of the 80% ethanol extract of M. nigra led to the identification of 22 phenolic compounds, with quinic acid as the major compound, followed by isoquercitrin and chlorogenic acid. The observed bioactivities may be attributed to the combined effects of these phenolic compounds. These findings suggest that M. nigra may serve as a promising natural source of phenolic compounds with potential inhibitory activity against enzymes associated with metabolic disorders.
SN  - 1612-1872
SN  - 1612-1880
ER  -