Green extraction of bioactive polysaccharides from Zanthoxylum bungeanum using deep eutectic solvents: enhanced yield, antioxidant activity, and functional hydrogel formation.
- 1College of Forestry, Northwest A&F University, Yangling, Shaanxi 712000, China.
Abstract
An ultrasound-assisted deep eutectic solvent (DES) method was developed for extracting polysaccharides from Zanthoxylum bungeanum pericarps (ZBP) and leaves (ZBLP). A choline chloride-oxalic acid (2:1) DES was selected. Under optimized conditions, yields of ZBP-D and ZBLP-D reached 25.88% and 29.79%, significantly higher than ultrasound-assisted water extraction (6.27% and 12.13%). DES-extracted polysaccharides shared similar structures but showed selectively enhanced antioxidant activity, with significantly lower IC₅₀ values against DPPH and hydroxyl radicals (0.231 mg/mL and 0.513 mg/mL for ZBP-D and ZBLP-D) compared to ultrasound-assisted water-extracted samples, although the latter performed better in the ABTS⁺ assay. The polysaccharides were formulated into hydrogels with dense porous networks, high swelling ratios (∼1200%), high loading ratios (∼69%), antioxidant retention, and hemocompatibility (safe load: 2.0 mg/mL for ZBP-D, 4.0 mg/mL for ZBLP-D). This green DES method enables efficient, bioactive polysaccharide extraction and hydrogel fabrication, providing a sustainable strategy for the value-added utilization of Z. bungeanum by-products.
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BibTeX
@article{wu2026green,
title = {{Green extraction of bioactive polysaccharides from Zanthoxylum bungeanum using deep eutectic solvents: enhanced yield, antioxidant activity, and functional hydrogel formation.}},
author = {Mengjia Wu and Guoxing Yu and Wenya Hu and Yulin Liu and Yonghong Liu},
journal = {Food chemistry: X},
year = {2026},
month = oct,
doi = {10.1016/j.fochx.2026.104612},
url = {https://europepmc.org/article/MED/42927227},
note = {CC BY},
}
RIS
TY - JOUR
TI - Green extraction of bioactive polysaccharides from Zanthoxylum bungeanum using deep eutectic solvents: enhanced yield, antioxidant activity, and functional hydrogel formation.
AU - Mengjia Wu
AU - Guoxing Yu
AU - Wenya Hu
AU - Yulin Liu
AU - Yonghong Liu
PY - 2026
DA - 2026/10/13
JO - Food chemistry: X
DO - 10.1016/j.fochx.2026.104612
UR - https://europepmc.org/article/MED/42927227
AB - An ultrasound-assisted deep eutectic solvent (DES) method was developed for extracting polysaccharides from Zanthoxylum bungeanum pericarps (ZBP) and leaves (ZBLP). A choline chloride-oxalic acid (2:1) DES was selected. Under optimized conditions, yields of ZBP-D and ZBLP-D reached 25.88% and 29.79%, significantly higher than ultrasound-assisted water extraction (6.27% and 12.13%). DES-extracted polysaccharides shared similar structures but showed selectively enhanced antioxidant activity, with significantly lower IC₅₀ values against DPPH and hydroxyl radicals (0.231 mg/mL and 0.513 mg/mL for ZBP-D and ZBLP-D) compared to ultrasound-assisted water-extracted samples, although the latter performed better in the ABTS⁺ assay. The polysaccharides were formulated into hydrogels with dense porous networks, high swelling ratios (∼1200%), high loading ratios (∼69%), antioxidant retention, and hemocompatibility (safe load: 2.0 mg/mL for ZBP-D, 4.0 mg/mL for ZBLP-D). This green DES method enables efficient, bioactive polysaccharide extraction and hydrogel fabrication, providing a sustainable strategy for the value-added utilization of Z. bungeanum by-products.
SN - 2590-1575
ER -