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Peer-reviewedCC BYClinical and Translational Radiation Oncology

FLASH reduces radiation-induced oral mucositis in a mouse model of Fanconi anemia

  • Phoebe Loo1
  • Margaret Pan2
  • Man Zhao1
  • Stavros Melemenidis1
  • Joseph B. Schulz1
  • Dixin Chen1
  • Lucy Whitmore3
  • Sara Richter1
  • Frederick M. Dirbas3
  • Kerriann M. Casey4
  • Edward E. Graves5
  • Michael W. Epperly6
3 more authors
  • Joel Greenberger6
  • Billy W. Loo, Jr.
  • Erinn B. Rankin
6 affiliations
  1. 1Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, United States of America
  2. 2Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, United States of America; Department of Comparative Medicine, Stanford University School of Medicine, Stanford, CA, 94305, United States of America
  3. 3Department of Surgery, Stanford University School of Medicine, Stanford, CA, 94305, United States of America
  4. 4Department of Comparative Medicine, Stanford University School of Medicine, Stanford, CA, 94305, United States of America
  5. 5Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, United States of America; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, 94305, United States of America
  6. 6Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA, 15260, United States of America
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Abstract

This study demonstrates that FLASH radiotherapy reduces oral mucositis in both wild-type and Fanca -deficient mice. At the cellular level, FLASH attenuated radiation-induced inflammation in the tongue relative to conventional irradiation in both genotypes, indicating that FLASH mitigates inflammatory processes associated with oral mucositis. Collectively, these findings support the potential of FLASH radiotherapy to reduce radiation-induced oral mucositis in the context of Fanca deficiency and the Fanconi anemia genomic background.

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Cite

BibTeXRIS
BibTeX
@article{loo2026flash,
  title = {{FLASH reduces radiation-induced oral mucositis in a mouse model of Fanconi anemia}},
  author = {Phoebe Loo and Margaret Pan and Man Zhao and Stavros Melemenidis and Joseph B. Schulz and Dixin Chen and Lucy Whitmore and Sara Richter and Frederick M. Dirbas and Kerriann M. Casey and Edward E. Graves and Michael W. Epperly and Joel Greenberger and Billy W. Loo, Jr. and Erinn B. Rankin},
  journal = {Clinical and Translational Radiation Oncology},
  year = {2026},
  month = oct,
  doi = {10.1016/j.ctro.2026.101334},
  url = {https://doi.org/10.1016/j.ctro.2026.101334},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - FLASH reduces radiation-induced oral mucositis in a mouse model of Fanconi anemia
AU  - Phoebe Loo
AU  - Margaret Pan
AU  - Man Zhao
AU  - Stavros Melemenidis
AU  - Joseph B. Schulz
AU  - Dixin Chen
AU  - Lucy Whitmore
AU  - Sara Richter
AU  - Frederick M. Dirbas
AU  - Kerriann M. Casey
AU  - Edward E. Graves
AU  - Michael W. Epperly
AU  - Joel Greenberger
AU  - Billy W. Loo, Jr.
AU  - Erinn B. Rankin
PY  - 2026
DA  - 2026/10/23
JO  - Clinical and Translational Radiation Oncology
DO  - 10.1016/j.ctro.2026.101334
UR  - https://doi.org/10.1016/j.ctro.2026.101334
AB  - This study demonstrates that FLASH radiotherapy reduces oral mucositis in both wild-type and Fanca -deficient mice. At the cellular level, FLASH attenuated radiation-induced inflammation in the tongue relative to conventional irradiation in both genotypes, indicating that FLASH mitigates inflammatory processes associated with oral mucositis. Collectively, these findings support the potential of FLASH radiotherapy to reduce radiation-induced oral mucositis in the context of Fanca deficiency and the Fanconi anemia genomic background.
SN  - 2405-6308
ER  -