Neuropsychosocial–Spiritual Correlates of Serene Abstinence in Adults with Alcohol Use Disorder Receiving Community-Based Recovery Care in Romania: A Longitudinal Observational Study Protocol (SER-ABS-AUD)
5 affiliations
- 1Doctoral School, Grigore T. Popa University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania
- 2Association of Recovering Alcoholics (ACAR) Don Orione Residential Centre, Rediu 21/C, 700546 Iași, Romania
- 3Third Medical Department, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iași, Romania
- 4“Gheorghe Zane” Institute for Economic and Social Research, Romanian Academy, 700481 Iași, Romania
- 5Socola Institute of Psychiatry, Bucium 36, 700282 Iași, Romania
Abstract
Background/Objectives: Alcohol use disorder (AUD) contributes substantially to premature mortality and disability in Romania. Recovery is commonly evaluated according to abstinence status, with less attention to psychological functioning, social support, spiritual well-being, and quality of life. SER-ABS-AUD (ClinicalTrials.gov identifier NCT07561749) examines ‘serene abstinence’ as a preliminary multidimensional recovery construct among adults with AUD receiving community-based recovery support. Methods: This single-center, non-interventional, mixed retrospective–prospective longitudinal cohort study aims to enroll 70 adults aged 18–70 years with documented AUD, at least 12 consecutive months of continuous alcohol abstinence before enrollment, and an archived pre-enrollment MCMI-IV profile. Following written informed consent at the current T2 study visit, archived T1 MCMI-IV data and available clinical information will be extracted, and the MCMI-IV and supplementary recovery-outcome battery will be administered prospectively at T2. The principal longitudinal outcome is within-person change in prespecified MCMI-IV scales between archived T1 and current T2 assessment. The secondary exploratory Serene Abstinence Index combines MCMI-IV persistent depression change with current T2 natural reward response, spiritual well-being, and quality of life. Supplementary T2 measures will be interpreted as current outcomes or concurrent exploratory correlates, not as repeated longitudinal measures. Results: Recruitment is ongoing; no participant-level outcome data are reported in this protocol. Conclusions: SER-ABS-AUD will estimate longitudinal MCMI-IV change and characterize multidimensional recovery in a Romanian community-based AUD setting. Findings will be hypothesis-generating and will require replication and external validation in larger, independent, multicentre cohorts.
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BibTeX
@article{gaina2026neuropsychosocialspiritual,
title = {{Neuropsychosocial–Spiritual Correlates of Serene Abstinence in Adults with Alcohol Use Disorder Receiving Community-Based Recovery Care in Romania: A Longitudinal Observational Study Protocol (SER-ABS-AUD)}},
author = {Alexandra-Maria Găină and Alexandra Hasnaș and Marcel-Alexandru Găină and Ionela-Ioana Darcaci and Bogdan-Victor Ștefănescu and Cristina-Gabriela Șchiopu and Bogdan-Marian Tarcău and Liviu-Adrian Măgurianu and Andreea-Silvana Szalontay},
journal = {Journal of Clinical Medicine},
year = {2026},
month = oct,
doi = {10.3390/jcm15218260},
url = {https://www.mdpi.com/2077-0383/15/21/8260},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Neuropsychosocial–Spiritual Correlates of Serene Abstinence in Adults with Alcohol Use Disorder Receiving Community-Based Recovery Care in Romania: A Longitudinal Observational Study Protocol (SER-ABS-AUD)
AU - Alexandra-Maria Găină
AU - Alexandra Hasnaș
AU - Marcel-Alexandru Găină
AU - Ionela-Ioana Darcaci
AU - Bogdan-Victor Ștefănescu
AU - Cristina-Gabriela Șchiopu
AU - Bogdan-Marian Tarcău
AU - Liviu-Adrian Măgurianu
AU - Andreea-Silvana Szalontay
PY - 2026
DA - 2026/10/23
JO - Journal of Clinical Medicine
DO - 10.3390/jcm15218260
UR - https://www.mdpi.com/2077-0383/15/21/8260
AB - Background/Objectives: Alcohol use disorder (AUD) contributes substantially to premature mortality and disability in Romania. Recovery is commonly evaluated according to abstinence status, with less attention to psychological functioning, social support, spiritual well-being, and quality of life. SER-ABS-AUD (ClinicalTrials.gov identifier NCT07561749) examines ‘serene abstinence’ as a preliminary multidimensional recovery construct among adults with AUD receiving community-based recovery support. Methods: This single-center, non-interventional, mixed retrospective–prospective longitudinal cohort study aims to enroll 70 adults aged 18–70 years with documented AUD, at least 12 consecutive months of continuous alcohol abstinence before enrollment, and an archived pre-enrollment MCMI-IV profile. Following written informed consent at the current T2 study visit, archived T1 MCMI-IV data and available clinical information will be extracted, and the MCMI-IV and supplementary recovery-outcome battery will be administered prospectively at T2. The principal longitudinal outcome is within-person change in prespecified MCMI-IV scales between archived T1 and current T2 assessment. The secondary exploratory Serene Abstinence Index combines MCMI-IV persistent depression change with current T2 natural reward response, spiritual well-being, and quality of life. Supplementary T2 measures will be interpreted as current outcomes or concurrent exploratory correlates, not as repeated longitudinal measures. Results: Recruitment is ongoing; no participant-level outcome data are reported in this protocol. Conclusions: SER-ABS-AUD will estimate longitudinal MCMI-IV change and characterize multidimensional recovery in a Romanian community-based AUD setting. Findings will be hypothesis-generating and will require replication and external validation in larger, independent, multicentre cohorts.
SN - 2077-0383
ER -