Polysaccharide-Based Biomaterials: Chemical Design and Advanced Dressings for Diabetic Chronic Wound Repair.
- 1Department of Spine Surgery, Qingdao Municipal Hospital, Qingdao Hospital of University of Health and Rehabilitation Sciences, Qingdao, 266000, People's Republic of China.
- 2Experimental Center of Clinical Pharmacology, Department of Pharmacy, Outpatient TCM Pharmacy, Qingdao Traditional Chinese Medicine Hospital, Qingdao Hiser Hospital Affiliated to Qingdao University, Qingdao, 266000, People's Republic of China.
Abstract
Diabetic foot ulcers, the typical manifestation of diabetic chronic wounds, pose a severe global public health burden. Such lesions feature a hyperglycemic microenvironment, sustained inflammation, severe oxidative stress, defective angiogenesis and recurrent bacterial infection, collectively leading to protracted healing, high relapse rates and elevated amputation risk. Natural polysaccharides, biocompatible and biodegradable macromolecules with low immunogenicity, exhibit versatile biofunctions including antibacterial, antioxidant, anti-inflammatory, pro-angiogenic and immunomodulatory effects via regulating macrophage polarization, making them ideal building blocks for wound repair dressings. Polysaccharide-derived dressings can absorb wound exudate, sustain moist microenvironments, eliminate reactive oxygen species, suppress pathogens/biofilms and facilitate angiogenesis and re-epithelialization to accelerate wound closure. Nevertheless, their clinical translation is restrained by ambiguous structure-activity relationships, inconsistent batch activity, undefined molecular mechanisms and bottlenecks in scalable manufacturing. This review first briefly summarizes the pathological traits of diabetic chronic wounds, classifies therapeutic polysaccharides by plant, animal and microbial origins, and emphatically discusses the chemical design, fabrication strategies, functional merits and underlying therapeutic mechanisms of multi-form polysaccharide biomaterials (hydrogels, nanofibers, microneedles, aerogels, etc). It delivers chemical-level theoretical guidance and process references for the subsequent fundamental investigation and industrial transformation of diabetic wound-healing biomaterials.
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BibTeX
@article{su2026polysaccharidebased,
title = {{Polysaccharide-Based Biomaterials: Chemical Design and Advanced Dressings for Diabetic Chronic Wound Repair.}},
author = {Xin Su and Wenting Yang and Li Qu and Jing Li},
journal = {International journal of general medicine},
year = {2026},
month = oct,
doi = {10.2147/ijgm.s642526},
url = {https://europepmc.org/article/MED/42910257},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Polysaccharide-Based Biomaterials: Chemical Design and Advanced Dressings for Diabetic Chronic Wound Repair.
AU - Xin Su
AU - Wenting Yang
AU - Li Qu
AU - Jing Li
PY - 2026
DA - 2026/10/17
JO - International journal of general medicine
DO - 10.2147/ijgm.s642526
UR - https://europepmc.org/article/MED/42910257
AB - Diabetic foot ulcers, the typical manifestation of diabetic chronic wounds, pose a severe global public health burden. Such lesions feature a hyperglycemic microenvironment, sustained inflammation, severe oxidative stress, defective angiogenesis and recurrent bacterial infection, collectively leading to protracted healing, high relapse rates and elevated amputation risk. Natural polysaccharides, biocompatible and biodegradable macromolecules with low immunogenicity, exhibit versatile biofunctions including antibacterial, antioxidant, anti-inflammatory, pro-angiogenic and immunomodulatory effects via regulating macrophage polarization, making them ideal building blocks for wound repair dressings. Polysaccharide-derived dressings can absorb wound exudate, sustain moist microenvironments, eliminate reactive oxygen species, suppress pathogens/biofilms and facilitate angiogenesis and re-epithelialization to accelerate wound closure. Nevertheless, their clinical translation is restrained by ambiguous structure-activity relationships, inconsistent batch activity, undefined molecular mechanisms and bottlenecks in scalable manufacturing. This review first briefly summarizes the pathological traits of diabetic chronic wounds, classifies therapeutic polysaccharides by plant, animal and microbial origins, and emphatically discusses the chemical design, fabrication strategies, functional merits and underlying therapeutic mechanisms of multi-form polysaccharide biomaterials (hydrogels, nanofibers, microneedles, aerogels, etc). It delivers chemical-level theoretical guidance and process references for the subsequent fundamental investigation and industrial transformation of diabetic wound-healing biomaterials.
SN - 1178-7074
ER -