Single Intrastromal Voriconazole Injection for Refractory Aspergillus flavus Keratitis.
- 1Adult Ophthalmology Department, Faculty of Medicine and Pharmacy of Casablanca, 20 August 1953 Hospital, Ibn Rochd University Hospital Center, Hassan II University, Casablanca, MAR.
Abstract
Fungal keratitis is a potentially vision-threatening infection that can be difficult to treat when it involves the deep corneal layers. We report the case of a 50-year-old woman who developed deep central fungal keratitis following vegetative ocular trauma. Microbiological analysis identified Aspergillus flavus (A. flavus). Despite intensive topical treatment with voriconazole 1% and amphotericin B 0.15%, the infiltrate progressed after one week. A single intrastromal injection of voriconazole (50 µg/0.1 mL) was administered circumferentially around the infiltrate. Progressive clinical improvement followed, with complete resolution within one month and no recurrence during two years of follow-up. Final visual acuity was 20/100, with residual corneal scarring. This case highlights the potential role of intrastromal voriconazole as a targeted treatment option for deep, refractory fungal keratitis.
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BibTeX
@article{fahmaoui2026single,
title = {{Single Intrastromal Voriconazole Injection for Refractory Aspergillus flavus Keratitis.}},
author = {Kaoutar Fahmaoui and Achraf Aneddame and Adil Mchachi and Laila Benhmidoune and Rachid Rayad},
journal = {Cureus},
year = {2026},
month = sep,
doi = {10.7759/cureus.116869},
url = {https://europepmc.org/article/MED/42927403},
note = {CC BY},
}
RIS
TY - JOUR
TI - Single Intrastromal Voriconazole Injection for Refractory Aspergillus flavus Keratitis.
AU - Kaoutar Fahmaoui
AU - Achraf Aneddame
AU - Adil Mchachi
AU - Laila Benhmidoune
AU - Rachid Rayad
PY - 2026
DA - 2026/09/24
JO - Cureus
DO - 10.7759/cureus.116869
UR - https://europepmc.org/article/MED/42927403
AB - Fungal keratitis is a potentially vision-threatening infection that can be difficult to treat when it involves the deep corneal layers. We report the case of a 50-year-old woman who developed deep central fungal keratitis following vegetative ocular trauma. Microbiological analysis identified Aspergillus flavus (A. flavus). Despite intensive topical treatment with voriconazole 1% and amphotericin B 0.15%, the infiltrate progressed after one week. A single intrastromal injection of voriconazole (50 µg/0.1 mL) was administered circumferentially around the infiltrate. Progressive clinical improvement followed, with complete resolution within one month and no recurrence during two years of follow-up. Final visual acuity was 20/100, with residual corneal scarring. This case highlights the potential role of intrastromal voriconazole as a targeted treatment option for deep, refractory fungal keratitis.
SN - 2168-8184
ER -