Genomic profiling of estrogen-related receptor identifies adult adipocyte-specific targets in Drosophila
- 1Center for Genomics and Bioinformatics, Indiana University , Bloomington, IN 47405 ,
- 2Department of Biology, Indiana University , Bloomington, IN 47405 ,
Abstract
Adipose tissue is a key metabolic organ for carbohydrate and lipid metabolism. Multiple nutrient sensing pathways and metabolic enzymes operate in adipocytes to control energy production and lipid mobilization in response to physiological conditions. Important regulators of glycolytic and lipid metabolism in many species are members of the estrogen-related receptor (ERR) family of nuclear receptors. We previously showed that ERR is required for transcriptional regulation of glycolytic and pentose phosphate pathway enzymes in adult Drosophila females, consistent with what is observed in ERR mutant males and larvae. However, the cell-type specific targets of ERR in adipose and other tissues have not been fully elucidated. Here, using a modified targeted DamID approach (NanoDam), we identified ERR occupancy specifically in adult adipocytes at the loci that encode genes involved in glycolysis, the pentose phosphate pathway, and fatty acid metabolism. Overall, our results predict that ERR centrally functions in adipose tissue to regulate multiple metabolic pathways.
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BibTeX
@article{yin2026genomic,
title = {{Genomic profiling of estrogen-related receptor identifies adult adipocyte-specific targets in Drosophila}},
author = {Jun Yin and Douglas B Rusch and Jitika S Bhatta and David M Merritt and Lesley N Weaver},
journal = {G3: Genes, Genomes, Genetics},
year = {2026},
month = oct,
doi = {10.1093/g3journal/jkag293},
url = {https://academic.oup.com/g3journal/advance-article/doi/10.1093/g3journal/jkag293/9003219},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Genomic profiling of estrogen-related receptor identifies adult adipocyte-specific targets in Drosophila
AU - Jun Yin
AU - Douglas B Rusch
AU - Jitika S Bhatta
AU - David M Merritt
AU - Lesley N Weaver
PY - 2026
DA - 2026/10/27
JO - G3: Genes, Genomes, Genetics
DO - 10.1093/g3journal/jkag293
UR - https://academic.oup.com/g3journal/advance-article/doi/10.1093/g3journal/jkag293/9003219
AB - Adipose tissue is a key metabolic organ for carbohydrate and lipid metabolism. Multiple nutrient sensing pathways and metabolic enzymes operate in adipocytes to control energy production and lipid mobilization in response to physiological conditions. Important regulators of glycolytic and lipid metabolism in many species are members of the estrogen-related receptor (ERR) family of nuclear receptors. We previously showed that ERR is required for transcriptional regulation of glycolytic and pentose phosphate pathway enzymes in adult Drosophila females, consistent with what is observed in ERR mutant males and larvae. However, the cell-type specific targets of ERR in adipose and other tissues have not been fully elucidated. Here, using a modified targeted DamID approach (NanoDam), we identified ERR occupancy specifically in adult adipocytes at the loci that encode genes involved in glycolysis, the pentose phosphate pathway, and fatty acid metabolism. Overall, our results predict that ERR centrally functions in adipose tissue to regulate multiple metabolic pathways.
SN - 2160-1836
ER -