Reconfigurable Magnetic Nanopore Platform for Selective Trapping
Abstract
Solid‐state nanopores offer a powerful platform for nanoscale analysis of individual analytes, including biomolecules and functionalized nanoparticles, by confining them within a precisely defined sensing region. However, their inherently passive operation restricts practical applications, as they cannot precisely control particle position or dynamics inside the pore. Here, we introduce magnetic nanopore architectures that integrate a ferromagnetic layer into the nanopore system. Acting as a magnetic discontinuity within an otherwise uniformly magnetized film, the nanopore generates localized stray magnetic fields that enable magnetic tweezing of magnetic nanoparticles, which can be functionalized with fluorescent biomolecules. Importantly, the nanopore geometry is designed to reversibly switch between a nearly uniform magnetization state and a magnetic flux‐closure state through the application of momentary magnetic fields of predetermined amplitude. This capability allows the magnetic tweezing effect to be selectively activated or deactivated, enabling controlled capture and release of tagged biomolecules on demand. As a proof of concept, we demonstrate the selective magnetic trapping of fluorescent magnetic particles. Our work establishes a robust and controllable approach for reconfigurable, on‐chip magnetic nanopore platforms capable of selective trapping and high‐throughput single‐particle detection.
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BibTeX
@article{sanamreddy2026reconfigurable,
title = {{Reconfigurable Magnetic Nanopore Platform for Selective Trapping}},
author = {Nageswar Reddy Sanamreddy and Jeanne Maunier and Malavika Kayyil Veedu and Anastasiia Sapunova and Nicolò Maccaferri and Denis Garoli and Jérôme Wenger and Paolo Vavassori},
journal = {Small Science},
year = {2026},
month = sep,
doi = {10.1002/smsc.70392},
url = {https://hal.science/hal-05848030v1},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Reconfigurable Magnetic Nanopore Platform for Selective Trapping
AU - Nageswar Reddy Sanamreddy
AU - Jeanne Maunier
AU - Malavika Kayyil Veedu
AU - Anastasiia Sapunova
AU - Nicolò Maccaferri
AU - Denis Garoli
AU - Jérôme Wenger
AU - Paolo Vavassori
PY - 2026
DA - 2026/09/08
JO - Small Science
DO - 10.1002/smsc.70392
UR - https://hal.science/hal-05848030v1
AB - Solid‐state nanopores offer a powerful platform for nanoscale analysis of individual analytes, including biomolecules and functionalized nanoparticles, by confining them within a precisely defined sensing region. However, their inherently passive operation restricts practical applications, as they cannot precisely control particle position or dynamics inside the pore. Here, we introduce magnetic nanopore architectures that integrate a ferromagnetic layer into the nanopore system. Acting as a magnetic discontinuity within an otherwise uniformly magnetized film, the nanopore generates localized stray magnetic fields that enable magnetic tweezing of magnetic nanoparticles, which can be functionalized with fluorescent biomolecules. Importantly, the nanopore geometry is designed to reversibly switch between a nearly uniform magnetization state and a magnetic flux‐closure state through the application of momentary magnetic fields of predetermined amplitude. This capability allows the magnetic tweezing effect to be selectively activated or deactivated, enabling controlled capture and release of tagged biomolecules on demand. As a proof of concept, we demonstrate the selective magnetic trapping of fluorescent magnetic particles. Our work establishes a robust and controllable approach for reconfigurable, on‐chip magnetic nanopore platforms capable of selective trapping and high‐throughput single‐particle detection.
SN - 2688-4046
ER -