Botanical Hybrid BioEntities with Antibacterial Activity Derived from Geranium robertianum-Biophysical Insights.
9 affiliations
- 1Department of Electricity, Solid-State Physics and Biophysics, Faculty of Physics, University of Bucharest, 405 Atomistilor, 077125 Magurele, Romania.
- 2National Institute for Laser, Plasma and Radiation Physics, 409 Atomistilor, 077125 Magurele, Romania.
- 3CTT-3Nano-SAE Research Center, Faculty of Physics, University of Bucharest, ICUB, 405 Atomistilor Street, P.O. Box MG-38, 077125 Magurele, Romania.
- 4National Institute for Chemical-Pharmaceutical Research and Development, 112 Vitan Avenue, 031299 Bucharest, Romania.
- 5Optospintronics Department, National Institute of Research and Development for Optoelectronics-INOE 2000, 409 Atomistilor, 077125 Magurele, Romania.
- 6Faculty of Biology, University of Bucharest, Splaiul Independentei 91-95, 050095 Bucharest, Romania.
- 7Research Institute of the University of Bucharest-ICUB, University of Bucharest, 050663 Bucharest, Romania.
- 8National Institute of Research and Development for Biological Sciences, Splaiul Independentei 296, 060031 Bucharest, Romania.
- 9CROMATEC PLUS SRL, 1 Petre Ispirescu Street, Tâncăbeşti, 077167 Ilfov, Romania.
Abstract
The present study reports the development of a novel botanical hybrid system obtained through the integration of Geranium robertianum L. phytochemicals, green-synthesized silver nanoparticles, and chlorophyll-loaded soybean lecithin biomimetic membranes. The proposed strategy combines the reducing and stabilizing capacity of plant-derived metabolites with the structural and functional advantages of membrane-inspired lipid assemblies. Silver nanoparticles were synthesized using aqueous Geranium robertianum extract, while biomimetic lipid vesicles were prepared from soybean lecithin and subsequently assembled into hybrid bioentities through a self-organization process. The obtained structures were characterized by UV-Vis spectroscopy, fluorescence spectroscopy, FTIR-ATR analysis, dynamic light scattering, zeta potential measurements, scanning electron microscopy, atomic force microscopy, and energy-dispersive X-ray spectroscopy. Optical investigations support the formation of phyto-capped silver nanoparticles and their successful incorporation into chlorophyll-containing biomimetic membranes. The hybrid structures exhibited improved colloidal stability, appropriate nanoscale dimensions, and characteristic morphological features indicative of efficient integration of the lipid and metallic components. Antioxidant and antibacterial investigations highlighted the combined contribution of the phytochemicals, silver nanostructures, and phospholipid matrix. These findings establish a versatile, environmentally friendly platform that bridges phytochemistry, nanotechnology, and biomimetic engineering, and may provide new opportunities for the development of multifunctional antimicrobial systems.
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BibTeX
@article{barbintapatrascu2026botanical,
title = {{Botanical Hybrid BioEntities with Antibacterial Activity Derived from Geranium robertianum-Biophysical Insights.}},
author = {Marcela-Elisabeta Barbinta-Patrascu and Irina Negut and Cornelia Nichita and Bogdan Bita and Vlad-Andrei Antohe and Georgiana-Alexandra Grigore and Diana-Madalina Gaboreanu and Adrian Bobica},
journal = {Biomimetics (Basel, Switzerland)},
year = {2026},
month = oct,
doi = {10.3390/biomimetics11100713},
url = {https://europepmc.org/article/MED/42930265},
note = {CC BY},
}
RIS
TY - JOUR
TI - Botanical Hybrid BioEntities with Antibacterial Activity Derived from Geranium robertianum-Biophysical Insights.
AU - Marcela-Elisabeta Barbinta-Patrascu
AU - Irina Negut
AU - Cornelia Nichita
AU - Bogdan Bita
AU - Vlad-Andrei Antohe
AU - Georgiana-Alexandra Grigore
AU - Diana-Madalina Gaboreanu
AU - Adrian Bobica
PY - 2026
DA - 2026/10/06
JO - Biomimetics (Basel, Switzerland)
DO - 10.3390/biomimetics11100713
UR - https://europepmc.org/article/MED/42930265
AB - The present study reports the development of a novel botanical hybrid system obtained through the integration of Geranium robertianum L. phytochemicals, green-synthesized silver nanoparticles, and chlorophyll-loaded soybean lecithin biomimetic membranes. The proposed strategy combines the reducing and stabilizing capacity of plant-derived metabolites with the structural and functional advantages of membrane-inspired lipid assemblies. Silver nanoparticles were synthesized using aqueous Geranium robertianum extract, while biomimetic lipid vesicles were prepared from soybean lecithin and subsequently assembled into hybrid bioentities through a self-organization process. The obtained structures were characterized by UV-Vis spectroscopy, fluorescence spectroscopy, FTIR-ATR analysis, dynamic light scattering, zeta potential measurements, scanning electron microscopy, atomic force microscopy, and energy-dispersive X-ray spectroscopy. Optical investigations support the formation of phyto-capped silver nanoparticles and their successful incorporation into chlorophyll-containing biomimetic membranes. The hybrid structures exhibited improved colloidal stability, appropriate nanoscale dimensions, and characteristic morphological features indicative of efficient integration of the lipid and metallic components. Antioxidant and antibacterial investigations highlighted the combined contribution of the phytochemicals, silver nanostructures, and phospholipid matrix. These findings establish a versatile, environmentally friendly platform that bridges phytochemistry, nanotechnology, and biomimetic engineering, and may provide new opportunities for the development of multifunctional antimicrobial systems.
SN - 2313-7673
ER -