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Peer-reviewedCC BY 4.0Frontiers in Neurology

Simultaneous evoked CMAP recording and sonography reveal a prolonged electromechanical delay in ALS patients

  • Sebastian A. Wölk1
  • Uwe Walter2,3
  • Johannes Prudlo2,3
  • Anne-Kathrin Ruß4
  • Robert Patejdl4
4 affiliations
  1. 1Oscar Langendorff Institute of Physiology, Rostock University Medical Center
  2. 2Department of Neurology, Rostock University Medical Center
  3. 3German Center for Neurodegenerative Diseases (DZNE) Rostock/Greifswald
  4. 4Department of Medicine, Health and Medical University Erfurt
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Abstract

Alterations in electromechanical coupling have been described in patients with amyotrophic lateral sclerosis (ALS) and may contribute to the pathophysiology of the disease. Regardless of this, few measurements of electromechanical delay (EMD) in ALS patients have been published. In this motor nerve conduction study, 28 patients with ALS were examined for changes in electromechanical coupling time compared to healthy individuals using sonoelectromyography, a novel dual-method approach combining simultaneous evoked compound muscle action potential (CMAP) recording following an ENG protocol with Doppler ultrasound. In the examination of four muscles (the abductor digiti minimi muscle, brachioradialis muscle, tibialis anterior muscle, and rectus femoris muscle) ALS patients exhibited prolonged electromechanical delay times. These results demonstrate alterations in the electromechanical properties of muscle fibers and provide further insight into muscle contractility in ALS. The findings support the advancement and wider utilisation of sonoelectromyography as an innovative tool for assessing muscle function and indicate that EMD could be incorporated into diagnostic and disease monitoring protocols in ALS.

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Cite

BibTeXRIS
BibTeX
@article{wolk2026simultaneous,
  title = {{Simultaneous evoked CMAP recording and sonography reveal a prolonged electromechanical delay in ALS patients}},
  author = {Sebastian A. Wölk and Uwe Walter and Johannes Prudlo and Anne-Kathrin Ruß and Robert Patejdl},
  journal = {Frontiers in Neurology},
  year = {2026},
  month = oct,
  doi = {10.3389/fneur.2026.1943566},
  url = {https://www.frontiersin.org/articles/10.3389/fneur.2026.1943566/full},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Simultaneous evoked CMAP recording and sonography reveal a prolonged electromechanical delay in ALS patients
AU  - Sebastian A. Wölk
AU  - Uwe Walter
AU  - Johannes Prudlo
AU  - Anne-Kathrin Ruß
AU  - Robert Patejdl
PY  - 2026
DA  - 2026/10/28
JO  - Frontiers in Neurology
DO  - 10.3389/fneur.2026.1943566
UR  - https://www.frontiersin.org/articles/10.3389/fneur.2026.1943566/full
AB  - Alterations in electromechanical coupling have been described in patients with amyotrophic lateral sclerosis (ALS) and may contribute to the pathophysiology of the disease. Regardless of this, few measurements of electromechanical delay (EMD) in ALS patients have been published. In this motor nerve conduction study, 28 patients with ALS were examined for changes in electromechanical coupling time compared to healthy individuals using sonoelectromyography, a novel dual-method approach combining simultaneous evoked compound muscle action potential (CMAP) recording following an ENG protocol with Doppler ultrasound. In the examination of four muscles (the abductor digiti minimi muscle, brachioradialis muscle, tibialis anterior muscle, and rectus femoris muscle) ALS patients exhibited prolonged electromechanical delay times. These results demonstrate alterations in the electromechanical properties of muscle fibers and provide further insight into muscle contractility in ALS. The findings support the advancement and wider utilisation of sonoelectromyography as an innovative tool for assessing muscle function and indicate that EMD could be incorporated into diagnostic and disease monitoring protocols in ALS.
SN  - 1664-2295
ER  -