Skip to content
DraconiticResearch
Search Sources API
186,123 studies31 sourcesUpdated 41 min ago
Peer-reviewedCC BY-NC-NDEJHaem

Nirmatrelvir/Ritonavir and Subsequent PCR Negativity in Patients With B-Cell Lymphoma and Prolonged SARS-CoV-2 PCR Positivity: A Case Series.

  • Yutaka Natori1
  • Hideyoshi Noji2
  • Akiko Shichishima-Nakamura2
  • Satoru Kikuchi2
  • Shigehira Saji1
  1. 1Department of Medical Oncology Fukushima Medical University Fukushima Japan.
  2. 2Department of Hematology Fukushima Minami Hospital Fukushima Japan.
Read full textPDFDOICite

Abstract

Prolonged SARS-CoV-2 PCR positivity is increasingly recognized in immunocompromised patients. We retrospectively analyzed four patients with B-cell lymphoma and prior anti-CD20 antibody therapy who exhibited prolonged PCR positivity after COVID-19 diagnosis. The median duration of PCR positivity was 57 days (range, 47-78 days); lymphoma treatment was interrupted in one patient and could not be resumed in another. Three patients received nirmatrelvir/ritonavir and became PCR negative 5-14 days after treatment initiation. These findings suggest that prolonged SARS-CoV-2 PCR positivity may disrupt lymphoma treatment and that PCR negativity was observed shortly after nirmatrelvir/ritonavir treatment in selected patients.

Related

  1. Effects and infection risks of baricitinib in combination with nirmatrelvir/ritonavir in elderly patients with severe or critical COVID-19: a retrospective observational cohort study.
    Ling Xu, Yongzhe Liu, Ran Li +6
    BMC infectious diseasesPeer-reviewedCC BY-NC-NDFull textInfectious diseaseEurope PMCPMC
  2. Takayasu Arteritis in a Middle-aged Woman Following Prolonged Subsequent Fever after COVID-19 Infection: An Early Diagnosis Using Contrast-enhanced CT
    Masayo Watanabe, Takuya Tanimoto, Mari Tanaka +6
    Internal MedicinePeer-reviewedCC BY-NC-NDFull textGeneral medicineJ-STAGE
  3. Prolonged passive vibration of Achilles and patellar tendons decreases effort perception during subsequent cycling tasks
    Florian Marchand, Benjamin Pageaux, Florian Monjo +1
    Journal of Sport and Health SciencePeer-reviewedCC BY-NC-ND 4.0Full text2 citedSurgery & anaesthesiaHAL
  4. Plasma concentrations of nirmatrelvir and molnupiravir required for inhibition of SARS-CoV-2 replication differ between rhesus macaques and humans
    Ugo Avila-Ponce de Leon, Shadisadat Esmaeili, Katherine Owens +1
    Antimicrobial Agents and ChemotherapyPeer-reviewedCC BY 4.0Full text1 citedPharmacology & toxicologyPMC
  5. Effects of Cannabidiol on Auditory Mismatch Negativity in Autistic Children
    K. Budhiraja, N.-F. Parrella, A. T. Hill +4
    medRxivPreprintCC BY-NC-NDFull textPsychiatry & mental healthmedRxiv

Cite

BibTeXRIS
BibTeX
@article{natori2026nirmatrelvirritonavir,
  title = {{Nirmatrelvir/Ritonavir and Subsequent PCR Negativity in Patients With B-Cell Lymphoma and Prolonged SARS-CoV-2 PCR Positivity: A Case Series.}},
  author = {Yutaka Natori and Hideyoshi Noji and Akiko Shichishima-Nakamura and Satoru Kikuchi and Shigehira Saji},
  journal = {EJHaem},
  year = {2026},
  month = oct,
  doi = {10.1002/jha2.70442},
  url = {https://europepmc.org/article/MED/42927348},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Nirmatrelvir/Ritonavir and Subsequent PCR Negativity in Patients With B-Cell Lymphoma and Prolonged SARS-CoV-2 PCR Positivity: A Case Series.
AU  - Yutaka Natori
AU  - Hideyoshi Noji
AU  - Akiko Shichishima-Nakamura
AU  - Satoru Kikuchi
AU  - Shigehira Saji
PY  - 2026
DA  - 2026/10/24
JO  - EJHaem
DO  - 10.1002/jha2.70442
UR  - https://europepmc.org/article/MED/42927348
AB  - Prolonged SARS-CoV-2 PCR positivity is increasingly recognized in immunocompromised patients. We retrospectively analyzed four patients with B-cell lymphoma and prior anti-CD20 antibody therapy who exhibited prolonged PCR positivity after COVID-19 diagnosis. The median duration of PCR positivity was 57 days (range, 47-78 days); lymphoma treatment was interrupted in one patient and could not be resumed in another. Three patients received nirmatrelvir/ritonavir and became PCR negative 5-14 days after treatment initiation. These findings suggest that prolonged SARS-CoV-2 PCR positivity may disrupt lymphoma treatment and that PCR negativity was observed shortly after nirmatrelvir/ritonavir treatment in selected patients.
SN  - 2688-6146
ER  -