Uncorking Quantitative and Qualitative Seminal Traits in French-Alpine Bucks via Carbetocin Stimulation to Enhance Goat Production in Semi-Arid Environments.
5 affiliations
- 1Graduate Program-Agricultural and Livestock Sciences, Laguna Unit, Antonio Narro Agrarian Autonomous University, Torreon 27054, Coahuila, Mexico.
- 2Graduate Program-Natural Resources and Environment in Arid Lands, Regional Universitary Unit on Arid Lands, Chapingo Autonomous University, Bermejillo 35230, Durango, Mexico.
- 3Division of Health, Biological and Environmental Sciences, Open and Distance University of Mexico, Ciudad de Mexico 03330, Mexico.
- 4Department of Sustainable and Protected Agriculture, Technological University of Rodeo, Rodeo 35760, Durango, Mexico.
- 5School of Engineering and Sciences, Tecnologico de Monterrey, Monterrey 64700, Nuevo Leon, Mexico.
Abstract
Optimizing semen collection is critical for maximizing genetic advancement and reproductive efficiency in livestock. While exogenous hormones can enhance ejaculate quantity and quality, short windows of biological activity often limit their efficacy. This study was conducted in northern-arid Mexico (25° N, 103 W) to evaluate the comparative effects of oxytocin (OXYT) and carbetocin (CARB) administration on semen quality in French-Alpine bucks. Males (n = 12) were allocated into three groups and received intravenous treatments 10 min prior to artificial vagina collection: (1) OXYT (10 UI oxytocin buck⁻¹), (2) CARB (0.2 mg 100 kg⁻¹ LW⁻¹), and (3) CONT (1 mL saline buck⁻¹). The same bucks received all three treatments separately. CARB outperformed both groups (p ≤ 0.05), improving all evaluated parameters (p ≤ 0.05): ejaculated volume (i.e., increased by 103%), sperm concentration, mass and progressive motility, total sperm count, viability, normal morphology, plasma membrane functionality, acrosome integrity, and chromatin dispersion. Crucially, CARB doubled (p ≤ 0.05) the available projected or theoretical number of doses for intravaginal artificial insemination (POTNDIAI), followed by the OXYT and CONT groups, with 11.14 POTNDIAI each. Therefore, CARB emerges as a highly effective, accessible pharmacological strategy for semen collection protocols, substantially enhancing sperm yield and structural quality in breeding bucks. Ultimately, by bridging advanced reproductive physiology with practical smallholder farming, this methodological optimization provides a viable strategy to enhance reproductive efficiency and long-term sustainability in small ruminant production systems within arid environments.
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BibTeX
@article{vargasgarcia2026uncorking,
title = {{Uncorking Quantitative and Qualitative Seminal Traits in French-Alpine Bucks via Carbetocin Stimulation to Enhance Goat Production in Semi-Arid Environments.}},
author = {Denia L Vargas-García and Cayetano Navarrete-Molina and César A Meza-Herrera and Ángeles De Santiago-Miramontes and Maurilio Solorio-Ochoa and Mayela Rodríguez-González and Irene Chavarría-Neri and María A Sariñana-Navarrete and Martín Alfredo Legarreta-González and Pedro Antonio Robles-Trillo},
journal = {Animals : an open access journal from MDPI},
year = {2026},
month = oct,
doi = {10.3390/ani16193157},
url = {https://europepmc.org/article/MED/42883126},
note = {CC BY},
}
RIS
TY - JOUR
TI - Uncorking Quantitative and Qualitative Seminal Traits in French-Alpine Bucks via Carbetocin Stimulation to Enhance Goat Production in Semi-Arid Environments.
AU - Denia L Vargas-García
AU - Cayetano Navarrete-Molina
AU - César A Meza-Herrera
AU - Ángeles De Santiago-Miramontes
AU - Maurilio Solorio-Ochoa
AU - Mayela Rodríguez-González
AU - Irene Chavarría-Neri
AU - María A Sariñana-Navarrete
AU - Martín Alfredo Legarreta-González
AU - Pedro Antonio Robles-Trillo
PY - 2026
DA - 2026/10/08
JO - Animals : an open access journal from MDPI
DO - 10.3390/ani16193157
UR - https://europepmc.org/article/MED/42883126
AB - Optimizing semen collection is critical for maximizing genetic advancement and reproductive efficiency in livestock. While exogenous hormones can enhance ejaculate quantity and quality, short windows of biological activity often limit their efficacy. This study was conducted in northern-arid Mexico (25° N, 103 W) to evaluate the comparative effects of oxytocin (OXYT) and carbetocin (CARB) administration on semen quality in French-Alpine bucks. Males (n = 12) were allocated into three groups and received intravenous treatments 10 min prior to artificial vagina collection: (1) OXYT (10 UI oxytocin buck⁻¹), (2) CARB (0.2 mg 100 kg⁻¹ LW⁻¹), and (3) CONT (1 mL saline buck⁻¹). The same bucks received all three treatments separately. CARB outperformed both groups (p ≤ 0.05), improving all evaluated parameters (p ≤ 0.05): ejaculated volume (i.e., increased by 103%), sperm concentration, mass and progressive motility, total sperm count, viability, normal morphology, plasma membrane functionality, acrosome integrity, and chromatin dispersion. Crucially, CARB doubled (p ≤ 0.05) the available projected or theoretical number of doses for intravaginal artificial insemination (POTNDIAI), followed by the OXYT and CONT groups, with 11.14 POTNDIAI each. Therefore, CARB emerges as a highly effective, accessible pharmacological strategy for semen collection protocols, substantially enhancing sperm yield and structural quality in breeding bucks. Ultimately, by bridging advanced reproductive physiology with practical smallholder farming, this methodological optimization provides a viable strategy to enhance reproductive efficiency and long-term sustainability in small ruminant production systems within arid environments.
SN - 2076-2615
ER -