Multifunctional vesicle-secreting bioadhesive dermatomimetic hydrogel for enhanced extensive wound healing
4 affiliations
- 1State Key Laboratory of Advanced Drug Delivery and Release Systems, Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
- 2Zhejiang Key Laboratory of Imaging and Interventional Medicine, Zhejiang Engineering Research Center of Interventional Medicine Engineering and Biotechnology, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China; Corresponding authors.
- 3Department of Pharmacy, Hangzhou Third People’s Hospital, Hangzhou 310058, China; Corresponding authors.
- 4State Key Laboratory of Advanced Drug Delivery and Release Systems, Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; Corresponding authors.
Abstract
Extensive skin wounds pose significant clinical challenges due to delayed healing, persistent inflammation and insufficient tissue regeneration. Here, we develop a photocrosslinked dermatomimetic hydrogel (DA-Col/HA) with bioadhesiveness and spatiotemporal controllability, composed of dopamine-conjugated collagen type III (DA-Col) and hyaluronic acid (HA). The DA-Col/HA gel, by mimicking the native extracellular matrix, promotes wound healing through accelerating hemostasis and its antioxidant/anti-inflammatory activities, specifically by scavenging ROS and inducing macrophage M2 polarization. On the other hand, the half-life of retinoic acid (RA), a key regulator of epithelial differentiation, is increased by 1.4 times after being encapsulated in adipose-derived stem cell extracellular vesicles (ADSC-EVs). In an extensive wound rat model, the mixture of RA-loaded ADSC-EVs and DA-Col/HA gel (EVs@RA-gel) significantly accelerates wound closure and facilitates the formation of follicle-like structures through enhanced re-epithelialization, accelerated neovascularization, and collagen deposition. Altogether, this multifunctional vesicle-secreting bioadhesive dermatomimetic hydrogel offers a promising therapeutic strategy for treating extensive skin wounds.
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BibTeX
@article{zhu2026multifunctional,
title = {{Multifunctional vesicle-secreting bioadhesive dermatomimetic hydrogel for enhanced extensive wound healing}},
author = {Jiawen Zhu and Xiaochuan Wu and Jialu Lang and Qi Zhu and Yuanyan Huang and Shihui Wu and Di Chen and Luwen Zhu and Jucong Zhang and Jiahao Hu and Jiayi Ding and Wei Wang and Yongzhong Du},
journal = {Asian Journal of Pharmaceutical Sciences},
year = {2026},
month = sep,
doi = {10.1016/j.ajps.2026.101204},
url = {https://doi.org/10.1016/j.ajps.2026.101204},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Multifunctional vesicle-secreting bioadhesive dermatomimetic hydrogel for enhanced extensive wound healing
AU - Jiawen Zhu
AU - Xiaochuan Wu
AU - Jialu Lang
AU - Qi Zhu
AU - Yuanyan Huang
AU - Shihui Wu
AU - Di Chen
AU - Luwen Zhu
AU - Jucong Zhang
AU - Jiahao Hu
AU - Jiayi Ding
AU - Wei Wang
AU - Yongzhong Du
PY - 2026
DA - 2026/09/25
JO - Asian Journal of Pharmaceutical Sciences
DO - 10.1016/j.ajps.2026.101204
UR - https://doi.org/10.1016/j.ajps.2026.101204
AB - Extensive skin wounds pose significant clinical challenges due to delayed healing, persistent inflammation and insufficient tissue regeneration. Here, we develop a photocrosslinked dermatomimetic hydrogel (DA-Col/HA) with bioadhesiveness and spatiotemporal controllability, composed of dopamine-conjugated collagen type III (DA-Col) and hyaluronic acid (HA). The DA-Col/HA gel, by mimicking the native extracellular matrix, promotes wound healing through accelerating hemostasis and its antioxidant/anti-inflammatory activities, specifically by scavenging ROS and inducing macrophage M2 polarization. On the other hand, the half-life of retinoic acid (RA), a key regulator of epithelial differentiation, is increased by 1.4 times after being encapsulated in adipose-derived stem cell extracellular vesicles (ADSC-EVs). In an extensive wound rat model, the mixture of RA-loaded ADSC-EVs and DA-Col/HA gel (EVs@RA-gel) significantly accelerates wound closure and facilitates the formation of follicle-like structures through enhanced re-epithelialization, accelerated neovascularization, and collagen deposition. Altogether, this multifunctional vesicle-secreting bioadhesive dermatomimetic hydrogel offers a promising therapeutic strategy for treating extensive skin wounds.
SN - 1818-0876
SN - 2221-285X
ER -