Skip to content
DraconiticResearch
Search Sources API
190,869 studies31 sourcesUpdated 40 min ago
Peer-reviewedCC BYVeterinary sciences

Research Progress on Seneca Valley Virus Infection in Swine: A Review.

  • Zhiqiang Hu1,2,3
  • Lili Wu4,5
  • Ran Guan1,2
  • Chaoyun Yang1
  • Xi Chen1
  • Zengwen Huang1
  • Guangwen Yan1
  • Guiying Hao1,2
5 affiliations
  1. 1College of Animal Science, Xichang University, Xichang 615013, China.
  2. 2Key Laboratory of Animal Epidemic Disease Detection and Prevention in Panxi District, Xichang University, Xichang 615013, China.
  3. 3Liangshan Ecological Breeding Engineering Technology Research Center, Xichang University, Xichang 615013, China.
  4. 4College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
  5. 5Shandong New Hope Liuhe Group Co., Ltd., Qingdao 266000, China.
Read full textPDFDOICite

Abstract

Seneca Valley virus (SVV), also referred to as Senecavirus A (SVA), is an emerging pathogen within the Picornaviridae family. Since its initial identification, SVV has been implicated in the onset of porcine idiopathic vesicular disease (PIVD) across several prominent pig-producing nations globally. Due to the clinical manifestations of SVV being challenging to differentiate from those of significant animal diseases such as foot-and-mouth disease (FMD), it poses considerable economic burdens and biosecurity challenges to the swine industry. This review endeavors to provide a comprehensive synthesis of the current state of research on SVV, systematically detailing its virological characteristics, molecular biology, global epidemiology, and evolutionary dynamics. The focus is placed on elucidating its pathogenic mechanisms in swine and the intricate molecular networks that govern its interactions with the host. Particular attention is given to the strategies employed by viral proteins to counteract host innate immune responses and to modulate autophagy, apoptosis, and other critical signaling pathways. Furthermore, we consolidate the existing diagnostic technologies and advancements in vaccine development, and we explore prospective research directions, aiming to furnish a reference for the clinical prevention and control of SVV.

Related

  1. Centrosomal protein 55: Research progress on biological characteristics, disease associations and clinical translational potential (Review)
    Sanmei Nong, Qiudong Huang, Kuibo Huang +5
    International Journal of Molecular MedicinePeer-reviewedCC BY-NC-ND 4.0Full textCell biologyPMC
  2. Research progress on intestinal probiotics-mediated protection of the intestinal mucosal barrier in ulcerative colitis
    Guiping Ma, Shurong Deng
    Frontiers in immunologyPeer-reviewedCC BYFull textImmunologyEurope PMC
  3. Research progress on molecular mechanisms and signaling pathways of toxic metal exposure-induced lung fibrosis
    Dongmei Zhang, Wenwen Liu, Yanli Yang
    Frontiers in immunologyPeer-reviewedCC BYFull textImmunologyEurope PMC
  4. Research progress on the mechanisms by which gut microbiota dysbiosis remodels the bone marrow neuroimmune microenvironment to drive age-related osteoporosis
    Haoze Zhang, Zhong Wang, Tianwen Miao +2
    Frontiers in immunologyPeer-reviewedCC BYFull textImmunologyEurope PMC
  5. Mechanisms of antibody-dependent enhancement and its research progress in animal coronaviruses
    Zhiding Zhou, Yueyue Liu, Meilin Yang +4
    Veterinary ResearchPeer-reviewedCC BY 4.0Full textZoology & animal behaviourHAL

Cite

BibTeXRIS
BibTeX
@article{hu2026research,
  title = {{Research Progress on Seneca Valley Virus Infection in Swine: A Review.}},
  author = {Zhiqiang Hu and Lili Wu and Ran Guan and Chaoyun Yang and Xi Chen and Zengwen Huang and Guangwen Yan and Guiying Hao},
  journal = {Veterinary sciences},
  year = {2026},
  month = oct,
  doi = {10.3390/vetsci13101106},
  url = {https://europepmc.org/article/MED/42944200},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Research Progress on Seneca Valley Virus Infection in Swine: A Review.
AU  - Zhiqiang Hu
AU  - Lili Wu
AU  - Ran Guan
AU  - Chaoyun Yang
AU  - Xi Chen
AU  - Zengwen Huang
AU  - Guangwen Yan
AU  - Guiying Hao
PY  - 2026
DA  - 2026/10/17
JO  - Veterinary sciences
DO  - 10.3390/vetsci13101106
UR  - https://europepmc.org/article/MED/42944200
AB  - Seneca Valley virus (SVV), also referred to as Senecavirus A (SVA), is an emerging pathogen within the Picornaviridae family. Since its initial identification, SVV has been implicated in the onset of porcine idiopathic vesicular disease (PIVD) across several prominent pig-producing nations globally. Due to the clinical manifestations of SVV being challenging to differentiate from those of significant animal diseases such as foot-and-mouth disease (FMD), it poses considerable economic burdens and biosecurity challenges to the swine industry. This review endeavors to provide a comprehensive synthesis of the current state of research on SVV, systematically detailing its virological characteristics, molecular biology, global epidemiology, and evolutionary dynamics. The focus is placed on elucidating its pathogenic mechanisms in swine and the intricate molecular networks that govern its interactions with the host. Particular attention is given to the strategies employed by viral proteins to counteract host innate immune responses and to modulate autophagy, apoptosis, and other critical signaling pathways. Furthermore, we consolidate the existing diagnostic technologies and advancements in vaccine development, and we explore prospective research directions, aiming to furnish a reference for the clinical prevention and control of SVV.
SN  - 2306-7381
ER  -