Association Between Cholesterol‐HDL‐Glucose (CHG) Index and New‐Onset Hypertension Across Different Sex and Glycemic Status: A Longitudinal Study With 9‐Year Follow‐Up
- 1JiuJiang City Key Laboratory of Cell Therapy JiuJiang NO. 1 People's Hospital Jiujiang China
- 2Department of Cardiovascular Medicine Jiujiang NO. 1 People's Hospital Jiujiang China
Abstract
Background: Hypertension is a major global public health issue, and the continuous search for new biomarkers to optimize risk stratification is crucial. This study aims to investigate the relationship between a novel metabolic disorder diagnostic tool—cholesterol, high‐density lipoprotein, and glucose (CHG) index—and the incidence of hypertension in populations with different sexes and glycemic statuses.
Methods: This study utilized 9 years of follow‐up data from the China Health and Retirement Longitudinal Study. Logistic regression models were employed to examine the association between the CHG index and new‐onset hypertension across different sex and glycemic statuses. Additionally, the net reclassification improvement and integrated discrimination improvement indices were calculated to estimate the additional predictive value beyond the basic model.
Results: A total of 6555 participants were included in the study. A significant association between CHG index and new‐onset hypertension was observed in the total, male, female, prediabetic, and diabetic populations, with adjusted OR (95% CI) of 1.16 (1.10–1.24), 1.23 (1.12–1.36), 1.12 (1.02–1.22), 1.14 (1.01–1.29), and 1.19 (1.03–1.36) respectively. Restricted Cubic Spline (RCS) analysis revealed a positive linear relationship between the CHG index and new‐onset hypertension. The addition of either the CHG index or the Triglyceride‐Glucose (TyG) index significantly improved the predictive performance of the basic model for hypertension.
Conclusions: An elevated CHG index is significantly associated with new‐onset hypertension.
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BibTeX
@article{he2026association,
title = {{Association Between Cholesterol‐HDL‐Glucose (CHG) Index and New‐Onset Hypertension Across Different Sex and Glycemic Status: A Longitudinal Study With 9‐Year Follow‐Up}},
author = {Huabin He and Jianhai Chen},
journal = {Endocrinology, Diabetes \& Metabolism},
year = {2026},
month = nov,
doi = {10.1002/edm2.70365},
url = {https://doi.org/10.1002/edm2.70365},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Association Between Cholesterol‐HDL‐Glucose (CHG) Index and New‐Onset Hypertension Across Different Sex and Glycemic Status: A Longitudinal Study With 9‐Year Follow‐Up
AU - Huabin He
AU - Jianhai Chen
PY - 2026
DA - 2026/11/03
JO - Endocrinology, Diabetes & Metabolism
DO - 10.1002/edm2.70365
UR - https://doi.org/10.1002/edm2.70365
AB - Background: Hypertension is a major global public health issue, and the continuous search for new biomarkers to optimize risk stratification is crucial. This study aims to investigate the relationship between a novel metabolic disorder diagnostic tool—cholesterol, high‐density lipoprotein, and glucose (CHG) index—and the incidence of hypertension in populations with different sexes and glycemic statuses. Methods: This study utilized 9 years of follow‐up data from the China Health and Retirement Longitudinal Study. Logistic regression models were employed to examine the association between the CHG index and new‐onset hypertension across different sex and glycemic statuses. Additionally, the net reclassification improvement and integrated discrimination improvement indices were calculated to estimate the additional predictive value beyond the basic model. Results: A total of 6555 participants were included in the study. A significant association between CHG index and new‐onset hypertension was observed in the total, male, female, prediabetic, and diabetic populations, with adjusted OR (95% CI) of 1.16 (1.10–1.24), 1.23 (1.12–1.36), 1.12 (1.02–1.22), 1.14 (1.01–1.29), and 1.19 (1.03–1.36) respectively. Restricted Cubic Spline (RCS) analysis revealed a positive linear relationship between the CHG index and new‐onset hypertension. The addition of either the CHG index or the Triglyceride‐Glucose (TyG) index significantly improved the predictive performance of the basic model for hypertension. Conclusions: An elevated CHG index is significantly associated with new‐onset hypertension.
SN - 2398-9238
ER -