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Peer-reviewedCC BY 4.0Case Reports in Critical Care

Case Report: Sepsis With Multisystemic Amyloid Light‐Chain Amyloidosis

  • Mehtap Selçuk1
  • Galip Emre Kılıçaslan2
  • Sinem Keskin Kayalar1
  • Ismail Cinel2
  1. 1Acıbadem Ataşehir Hospital Istanbul Turkey
  2. 2Department of Anesthesiology and Reanimation Department of Intensive Care Acıbadem University Medical Faculty Istanbul Turkey acibadem.edu.tr
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Abstract

Introduction: Systemic light‐chain (AL) amyloidosis is a complex disorder characterized by extracellular fibril deposition, leading to severe multisystem dysfunction. When sepsis superimposes on preexisting organ impairment, early clinical recognition becomes particularly challenging yet critical.

Methods: We present a case of a 60‐year‐old female who presented with generalized edema, dyspnea, and cardiac/renal involvement, subsequently diagnosed with AL amyloidosis based on laboratory, imaging, bone marrow biopsy, and Congo red staining findings.

Results: Following chemotherapy with bortezomib and cyclophosphamide, the patient experienced transient cardiac arrest, received an implantable cardioverter defibrillator, and subsequently developed massive ascites. Upon developing Pseudomonas guariconensis bacteremia, she progressed to septic shock requiring intensive care unit admission, mechanical ventilation, vasopressor support, and targeted antimicrobial therapy. Through aggressive supportive care and source control, hemodynamic stabilization was achieved, allowing successful extubation and transfer to the general ward.

Conclusions: Superimposed sepsis on severe, multi‐organ amyloidosis significantly complicates diagnosis and management. High clinical vigilance, early infection recognition, and prompt targeted therapy are essential to prevent fatal outcomes in patients with preexisting chronic organ dysfunctions.

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Cite

BibTeXRIS
BibTeX
@article{selcuk2026case,
  title = {{Case Report: Sepsis With Multisystemic Amyloid Light‐Chain Amyloidosis}},
  author = {Mehtap Selçuk and Galip Emre Kılıçaslan and Sinem Keskin Kayalar and Ismail Cinel},
  journal = {Case Reports in Critical Care},
  year = {2026},
  month = oct,
  doi = {10.1155/crcc/6794847},
  url = {https://doi.org/10.1155/crcc/6794847},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Case Report: Sepsis With Multisystemic Amyloid Light‐Chain Amyloidosis
AU  - Mehtap Selçuk
AU  - Galip Emre Kılıçaslan
AU  - Sinem Keskin Kayalar
AU  - Ismail Cinel
PY  - 2026
DA  - 2026/10/26
JO  - Case Reports in Critical Care
DO  - 10.1155/crcc/6794847
UR  - https://doi.org/10.1155/crcc/6794847
AB  - Introduction: Systemic light‐chain (AL) amyloidosis is a complex disorder characterized by extracellular fibril deposition, leading to severe multisystem dysfunction. When sepsis superimposes on preexisting organ impairment, early clinical recognition becomes particularly challenging yet critical.  Methods: We present a case of a 60‐year‐old female who presented with generalized edema, dyspnea, and cardiac/renal involvement, subsequently diagnosed with AL amyloidosis based on laboratory, imaging, bone marrow biopsy, and Congo red staining findings.  Results: Following chemotherapy with bortezomib and cyclophosphamide, the patient experienced transient cardiac arrest, received an implantable cardioverter defibrillator, and subsequently developed massive ascites. Upon developing Pseudomonas guariconensis bacteremia, she progressed to septic shock requiring intensive care unit admission, mechanical ventilation, vasopressor support, and targeted antimicrobial therapy. Through aggressive supportive care and source control, hemodynamic stabilization was achieved, allowing successful extubation and transfer to the general ward.  Conclusions: Superimposed sepsis on severe, multi‐organ amyloidosis significantly complicates diagnosis and management. High clinical vigilance, early infection recognition, and prompt targeted therapy are essential to prevent fatal outcomes in patients with preexisting chronic organ dysfunctions.
SN  - 2090-6420
SN  - 2090-6439
ER  -