Peer-reviewedCC BY-NC-NDInternal Medicine
A 15-year Follow-up of Persistent Pulmonary Lesions after Silicone Removal in a Patient with Silicon-induced Autoimmune/Inflammatory Syndrome
Abstract
A 65-year-old woman with a history of silicone breast implantation was admitted to our hospital with abnormal chest shadows. Although the implants had already been removed, chest CT revealed diffuse ground-glass opacities in both lungs. Thoracoscopic lung biopsy revealed non-necrotizing epithelioid granulomas and silica-phagocytic macrophages, leading to a diagnosis of silicone-implant-associated autoimmune/inflammatory syndrome induced by adjuvants (ASIA). Over a follow-up period of more than 15 years without treatment, the ground-glass opacities improved only slightly. We herein present the longest follow-up chest CT findings of silicone implant-associated ASIA.
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BibTeX
@article{watanabe202615year,
title = {{A 15-year Follow-up of Persistent Pulmonary Lesions after Silicone Removal in a Patient with Silicon-induced Autoimmune/Inflammatory Syndrome}},
author = {Natsumi Watanabe and Yoshinori Tanino and Takefumi Nikaido and Yuki Sato and Ryuichi Togawa and Xintao Wang and Naoko Fukuhara and Tetsuya Egawa and Takahiro Kumanaka and Ryutaro Tanaka and Kentaro Kazama and Koshi Saito and Rina Harigane and Ryuki Yamada and Riko Sato and Hikaru Tomita and Mami Rikimaru and Takashi Umeda and Yasuhito Suzuki and Junpei Saito and Kenya Kanazawa and Hiroyuki Suzuki and Yuko Hashimoto and Akira Hebisawa and Yoko Shibata},
journal = {Internal Medicine},
year = {2026},
month = aug,
doi = {10.2169/internalmedicine.5944-25},
url = {https://www.jstage.jst.go.jp/article/internalmedicine/65/15/65_5944-25/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - A 15-year Follow-up of Persistent Pulmonary Lesions after Silicone Removal in a Patient with Silicon-induced Autoimmune/Inflammatory Syndrome
AU - Natsumi Watanabe
AU - Yoshinori Tanino
AU - Takefumi Nikaido
AU - Yuki Sato
AU - Ryuichi Togawa
AU - Xintao Wang
AU - Naoko Fukuhara
AU - Tetsuya Egawa
AU - Takahiro Kumanaka
AU - Ryutaro Tanaka
AU - Kentaro Kazama
AU - Koshi Saito
AU - Rina Harigane
AU - Ryuki Yamada
AU - Riko Sato
AU - Hikaru Tomita
AU - Mami Rikimaru
AU - Takashi Umeda
AU - Yasuhito Suzuki
AU - Junpei Saito
AU - Kenya Kanazawa
AU - Hiroyuki Suzuki
AU - Yuko Hashimoto
AU - Akira Hebisawa
AU - Yoko Shibata
PY - 2026
DA - 2026/08/01
JO - Internal Medicine
DO - 10.2169/internalmedicine.5944-25
UR - https://www.jstage.jst.go.jp/article/internalmedicine/65/15/65_5944-25/_article
AB - A 65-year-old woman with a history of silicone breast implantation was admitted to our hospital with abnormal chest shadows. Although the implants had already been removed, chest CT revealed diffuse ground-glass opacities in both lungs. Thoracoscopic lung biopsy revealed non-necrotizing epithelioid granulomas and silica-phagocytic macrophages, leading to a diagnosis of silicone-implant-associated autoimmune/inflammatory syndrome induced by adjuvants (ASIA). Over a follow-up period of more than 15 years without treatment, the ground-glass opacities improved only slightly. We herein present the longest follow-up chest CT findings of silicone implant-associated ASIA.
SN - 1349-7235
SN - 0918-2918
ER -