Immunomodulation and biofilm disruption of piezoelectric materials in bone infection
- 1Trauma Medical Center, Department of Orthopedic Surgery, West China Hospital, Sichuan University , ,
- 2Operating Room, Department of Anesthesiology, West China Hospital, Sichuan University , ,
Abstract
Bone infection remains a persistent clinical challenge due to biofilm formation, antibiotic resistance, and impaired bone regeneration. This manuscript focuses on the application of piezoelectric biomaterials in the treatment of bone infection and systematically elucidates their ability to convert in vivo mechanical stimulation into localized electrical signals and, in catalytically active systems, promote reactive oxygen species generation, thereby enabling efficient bacterial eradication and biofilm disruption. We further synthesize recent evidence showing that piezoelectric stimulation can modulate the infection-associated immune microenvironment and support osteogenesis and angiogenesis. Rather than considering antibacterial, immunomodulatory, and regenerative effects as parallel functions, we integrate them into a stage-adaptive therapeutic framework in which early biofilm disruption, bacterial eradication, and antimicrobial immune activation are followed by oxidative-stress control, inflammation resolution, pro-reparative immune remodeling, angiogenesis, and osteogenesis. This pathophysiology-oriented perspective highlights the potential of piezoelectric materials to coordinate the sequential therapeutic requirements of infected bone repair. Finally, current challenges and future perspectives regarding material design optimization, mechanistic understanding, and clinical translation are discussed.
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BibTeX
@article{wang2026immunomodulation,
title = {{Immunomodulation and biofilm disruption of piezoelectric materials in bone infection}},
author = {Zhen Wang and Kai Zheng and Yunfeng Tang and Zhen Zhang and Zhou Zhong and Dong Wang and Zijian Chen and Ye Wang and Zan Chen and Pengrui Feng and Wenjie Huang and Mengkun Liu and Yun Hao and Feng Yu and Guanglin Wang and Min Yi and Xiangtian Deng},
journal = {Frontiers in cell and developmental biology},
year = {2026},
month = oct,
doi = {10.3389/fcell.2026.1976300},
url = {https://europepmc.org/article/PMC/PMC13719893},
note = {CC BY},
}
RIS
TY - JOUR
TI - Immunomodulation and biofilm disruption of piezoelectric materials in bone infection
AU - Zhen Wang
AU - Kai Zheng
AU - Yunfeng Tang
AU - Zhen Zhang
AU - Zhou Zhong
AU - Dong Wang
AU - Zijian Chen
AU - Ye Wang
AU - Zan Chen
AU - Pengrui Feng
AU - Wenjie Huang
AU - Mengkun Liu
AU - Yun Hao
AU - Feng Yu
AU - Guanglin Wang
AU - Min Yi
AU - Xiangtian Deng
PY - 2026
DA - 2026/10/16
JO - Frontiers in cell and developmental biology
DO - 10.3389/fcell.2026.1976300
UR - https://europepmc.org/article/PMC/PMC13719893
AB - Bone infection remains a persistent clinical challenge due to biofilm formation, antibiotic resistance, and impaired bone regeneration. This manuscript focuses on the application of piezoelectric biomaterials in the treatment of bone infection and systematically elucidates their ability to convert in vivo mechanical stimulation into localized electrical signals and, in catalytically active systems, promote reactive oxygen species generation, thereby enabling efficient bacterial eradication and biofilm disruption. We further synthesize recent evidence showing that piezoelectric stimulation can modulate the infection-associated immune microenvironment and support osteogenesis and angiogenesis. Rather than considering antibacterial, immunomodulatory, and regenerative effects as parallel functions, we integrate them into a stage-adaptive therapeutic framework in which early biofilm disruption, bacterial eradication, and antimicrobial immune activation are followed by oxidative-stress control, inflammation resolution, pro-reparative immune remodeling, angiogenesis, and osteogenesis. This pathophysiology-oriented perspective highlights the potential of piezoelectric materials to coordinate the sequential therapeutic requirements of infected bone repair. Finally, current challenges and future perspectives regarding material design optimization, mechanistic understanding, and clinical translation are discussed.
SN - 2296-634X
ER -