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Peer-reviewedCC BY 4.0Clinical Case Reports

A Rare Case of Appendiceal Metastasis From Prostate Adenocarcinoma in an Asymptomatic Patient With Biochemical Recurrence

  • Antonio Muina1
  • Mohamed Javid Raja Iyub2
  • Michael Toussaint1
  • Murugesan Manoharan2,3
  1. 1St. George University School of Medicine St. George's Grenada
  2. 2Miami Cancer Institute Baptist Health South Florida Miami Florida USA
  3. 3Herbert Wertheim College of Medicine Florida International University Miami Florida USA
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Abstract

We report a rare case of appendiceal metastasis from prostate adenocarcinoma in a 73‐year‐old male with a prior Gleason score 7 prostate cancer, initially treated with radical prostatectomy and adjuvant radiation in 2014. The patient presented in 2025 with a rising prostate‐specific antigen (PSA) and modest prostate‐specific membrane antigen (PSMA) uptake on positron emission tomography/computed tomography (PET/CT) at the tip of the appendix. Magnetic resonance imaging (MRI) demonstrated a corresponding appendiceal lesion with restricted diffusion and enhancement. Pathology following laparoscopic appendectomy confirmed metastatic prostate adenocarcinoma involving the appendix and periappendiceal lymph nodes. This case highlights the importance of correlating atypical PSMA PET/CT findings with anatomic imaging and, when needed, histologic confirmation in patients with biochemical recurrence of prostate cancer.

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Cite

BibTeXRIS
BibTeX
@article{muina2026rare,
  title = {{A Rare Case of Appendiceal Metastasis From Prostate Adenocarcinoma in an Asymptomatic Patient With Biochemical Recurrence}},
  author = {Antonio Muina and Mohamed Javid Raja Iyub and Michael Toussaint and Murugesan Manoharan},
  journal = {Clinical Case Reports},
  year = {2026},
  month = nov,
  doi = {10.1002/ccr3.73839},
  url = {https://doi.org/10.1002/ccr3.73839},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - A Rare Case of Appendiceal Metastasis From Prostate Adenocarcinoma in an Asymptomatic Patient With Biochemical Recurrence
AU  - Antonio Muina
AU  - Mohamed Javid Raja Iyub
AU  - Michael Toussaint
AU  - Murugesan Manoharan
PY  - 2026
DA  - 2026/11/03
JO  - Clinical Case Reports
DO  - 10.1002/ccr3.73839
UR  - https://doi.org/10.1002/ccr3.73839
AB  - We report a rare case of appendiceal metastasis from prostate adenocarcinoma in a 73‐year‐old male with a prior Gleason score 7 prostate cancer, initially treated with radical prostatectomy and adjuvant radiation in 2014. The patient presented in 2025 with a rising prostate‐specific antigen (PSA) and modest prostate‐specific membrane antigen (PSMA) uptake on positron emission tomography/computed tomography (PET/CT) at the tip of the appendix. Magnetic resonance imaging (MRI) demonstrated a corresponding appendiceal lesion with restricted diffusion and enhancement. Pathology following laparoscopic appendectomy confirmed metastatic prostate adenocarcinoma involving the appendix and periappendiceal lymph nodes. This case highlights the importance of correlating atypical PSMA PET/CT findings with anatomic imaging and, when needed, histologic confirmation in patients with biochemical recurrence of prostate cancer.
SN  - 2050-0904
ER  -