4-Thiazolidinone/2,4-Thiazolidinedione-Sulfonamide Hybrids: A Concise Review of Their Design and Pharmacological Significance.
4 affiliations
- 1Tuberculosis Research Laboratory, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, Brazil.
- 2Laboratory of Drug Planning and Development, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, Brazil.
- 3Sage Institute of Research and Technology-Pharmacy, Sanjeev Agrawal Global Educational University (SAGE), Bhopal, India.
- 4Vicerrectorado de Investigación, Universidad Católica de Santa María, Arequipa, Peru.
Abstract
Molecular hybridization represents a promising strategy in drug-design and the discovery of novel biologically active molecules, as it can enhance molecular affinity and potency while simultaneously reducing resistance and side effects. This review explores the recent advancements in the design, synthesis, and biological evaluation of hybrid molecules that combine sulfonamide with thiazolidinone or thiazolidine-2,4-dione scaffolds. The review covered studies published from 2009 to 2025 and focused exclusively on compounds containing both a sulfonamide moiety and a thiazolidinone or thiazolidinedione framework in the same molecule. These hybrid compounds have attracted considerable attention due to their potential to address the complexity of multifactorial diseases such as cancer, infections, and metabolic disorders, which often involve multiple biological pathways. By integrating features from both sulfonamides and thiazolidines, researchers have developed molecules with enhanced pharmacological profiles, including improved antimicrobial, anticancer, anti-inflammatory, antidiabetic, and anticonvulsant activities. The review highlights how these hybrids often display multitarget effects, making them promising candidates for overcoming limitations of traditional single-target drugs, such as resistance and limited efficacy. Key findings from recent studies are summarized, with a focus on the structural aspects that contribute to biological activity. Sulfonamide-thiazolidinone and sulfonamide-thiazolidinedione hybrids represent a versatile and valuable strategy in the search for new treatments for complex diseases.
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BibTeX
@article{vishwakarma20264thiazolidinone24thiazolidinedionesulfonamide,
title = {{4-Thiazolidinone/2,4-Thiazolidinedione-Sulfonamide Hybrids: A Concise Review of Their Design and Pharmacological Significance.}},
author = {Subham Kumar Vishwakarma and Andressa Francielli Bonjorno and Sukhwant Singh and Christian S Carnero Canales and Jean Leandro Dos Santos and Cesar Augusto Roque-Borda and Fernando Rogério Pavan},
journal = {ChemMedChem},
year = {2026},
month = oct,
doi = {10.1002/cmdc.70557},
url = {https://europepmc.org/article/MED/42951824},
note = {CC BY},
}
RIS
TY - JOUR
TI - 4-Thiazolidinone/2,4-Thiazolidinedione-Sulfonamide Hybrids: A Concise Review of Their Design and Pharmacological Significance.
AU - Subham Kumar Vishwakarma
AU - Andressa Francielli Bonjorno
AU - Sukhwant Singh
AU - Christian S Carnero Canales
AU - Jean Leandro Dos Santos
AU - Cesar Augusto Roque-Borda
AU - Fernando Rogério Pavan
PY - 2026
DA - 2026/10/01
JO - ChemMedChem
DO - 10.1002/cmdc.70557
UR - https://europepmc.org/article/MED/42951824
AB - Molecular hybridization represents a promising strategy in drug-design and the discovery of novel biologically active molecules, as it can enhance molecular affinity and potency while simultaneously reducing resistance and side effects. This review explores the recent advancements in the design, synthesis, and biological evaluation of hybrid molecules that combine sulfonamide with thiazolidinone or thiazolidine-2,4-dione scaffolds. The review covered studies published from 2009 to 2025 and focused exclusively on compounds containing both a sulfonamide moiety and a thiazolidinone or thiazolidinedione framework in the same molecule. These hybrid compounds have attracted considerable attention due to their potential to address the complexity of multifactorial diseases such as cancer, infections, and metabolic disorders, which often involve multiple biological pathways. By integrating features from both sulfonamides and thiazolidines, researchers have developed molecules with enhanced pharmacological profiles, including improved antimicrobial, anticancer, anti-inflammatory, antidiabetic, and anticonvulsant activities. The review highlights how these hybrids often display multitarget effects, making them promising candidates for overcoming limitations of traditional single-target drugs, such as resistance and limited efficacy. Key findings from recent studies are summarized, with a focus on the structural aspects that contribute to biological activity. Sulfonamide-thiazolidinone and sulfonamide-thiazolidinedione hybrids represent a versatile and valuable strategy in the search for new treatments for complex diseases.
SN - 1860-7179
SN - 1860-7187
ER -