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Peer-reviewedCC BY 4.0International Journal of Molecular Sciences

Biomodulators and Skin Boosters in Skin Rejuvenation: Mechanisms, Applications, and Future Perspectives

  • Zhiyuan Ding1,2
  • Caijun Jin1,2
  • Huizhen Ming1,2
  • Jung Hee Shim2
  • Vo Tien Huy3
  • Pham Ngoc Chien2
  • Chan Yeong Heo1,2
  1. 1Department of Plastic and Reconstructive Surgery, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea
  2. 2Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea
  3. 3Department of Anatomy, VNU University of Medicine and Pharmacy, Vietnam National University, Hanoi 100000, Vietnam
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Abstract

Biomodulators and skin boosters comprise heterogeneous preparations whose biological activity and clinical effects require separate evaluation. This structured narrative review distinguishes mechanistic plausibility from human comparative findings for skin aging, skin quality, and atrophic acne scars. A reproducible PubMed/MEDLINE search completed on 16 October 2026, followed by predefined screening, source retrieval, and eligibility adjudication, identified 159 comparative reports, each contributing one specified result. Risk-of-bias assessments classified 123 results as High and 36 as Some concerns; none was Low overall. Selected formulations and procedure-assisted regimens showed benefits for particular outcomes, whereas other comparisons were null or discordant. Hydration, tissue remodeling, clinical appearance, and patient satisfaction were treated as distinct outcomes. Retrospective result selection, heterogeneous interventions and outcomes, four access-unresolved reports, and the absence of a prospective protocol constrain confidence. Clinical claims should remain specific to the product, protocol, indication, comparator, and outcome investigated.

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Cite

BibTeXRIS
BibTeX
@article{ding2026biomodulators,
  title = {{Biomodulators and Skin Boosters in Skin Rejuvenation: Mechanisms, Applications, and Future Perspectives}},
  author = {Zhiyuan Ding and Caijun Jin and Huizhen Ming and Jung Hee Shim and Vo Tien Huy and Pham Ngoc Chien and Chan Yeong Heo},
  journal = {International Journal of Molecular Sciences},
  year = {2026},
  month = oct,
  doi = {10.3390/ijms27219647},
  url = {https://www.mdpi.com/1422-0067/27/21/9647},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Biomodulators and Skin Boosters in Skin Rejuvenation: Mechanisms, Applications, and Future Perspectives
AU  - Zhiyuan Ding
AU  - Caijun Jin
AU  - Huizhen Ming
AU  - Jung Hee Shim
AU  - Vo Tien Huy
AU  - Pham Ngoc Chien
AU  - Chan Yeong Heo
PY  - 2026
DA  - 2026/10/28
JO  - International Journal of Molecular Sciences
DO  - 10.3390/ijms27219647
UR  - https://www.mdpi.com/1422-0067/27/21/9647
AB  - Biomodulators and skin boosters comprise heterogeneous preparations whose biological activity and clinical effects require separate evaluation. This structured narrative review distinguishes mechanistic plausibility from human comparative findings for skin aging, skin quality, and atrophic acne scars. A reproducible PubMed/MEDLINE search completed on 16 October 2026, followed by predefined screening, source retrieval, and eligibility adjudication, identified 159 comparative reports, each contributing one specified result. Risk-of-bias assessments classified 123 results as High and 36 as Some concerns; none was Low overall. Selected formulations and procedure-assisted regimens showed benefits for particular outcomes, whereas other comparisons were null or discordant. Hydration, tissue remodeling, clinical appearance, and patient satisfaction were treated as distinct outcomes. Retrospective result selection, heterogeneous interventions and outcomes, four access-unresolved reports, and the absence of a prospective protocol constrain confidence. Clinical claims should remain specific to the product, protocol, indication, comparator, and outcome investigated.
SN  - 1422-0067
ER  -