Diet modulates metabolic and hepatic responses to chronic pesticide mixture exposure in mice
Abstract
Chronic exposure to pesticide mixtures through diet is common, yet their combined metabolic effects and interactions with dietary factors remain unclear. We identified four pesticides prevalent in human exposure (imazalil, thiabendazole, boscalid, lambda-cyhalothrin) and assessed their combined impacts on hepatic metabolism and metabolic homeostasis using human liver cells and male mice fed standard chow or western diets. We found that the pesticide mixture induced metabolic perturbations in human hepatocytes. In addition, the pesticide mixture altered hepatic gene expression in chow-fed mice and exacerbated western diet-induced glucose intolerance, fasting hyperglycemia, and insulin resistance without affecting body weight or liver steatosis. These findings reveal that dietary context influences the metabolic consequences of pesticide mixtures, highlighting the need to consider nutritional status when evaluating environmental contaminant risks. Our results suggest that pesticide mixtures at reference doses may contribute to metabolic dysregulation, particularly under obesogenic dietary conditions.
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BibTeX
@article{rives2026diet,
title = {{Diet modulates metabolic and hepatic responses to chronic pesticide mixture exposure in mice}},
author = {C. Rives and N. Poirier-Jaouen and Y. Malaisé and C. Martin and M. Huillet and S. Ellero-Simatos and P. Perrier and A. Polizzi and F. Lasserre and V. Alquier-Bacquié and C. Guyon and Y. Lippi and C. Naylies and C. Comera and H. Budzinski and K. Le Menach and E. Jamin and N. Dieng and R. Vuillaume and C. Orlandi and J. Gomez and S. Costes and A. Arrar and A. Lucas and S. Fried and E. Boutet-Robinet and J. Guillermet-Guibert and E. Kesse-Guyot and H. Guillou and N. Loiseau and A. Fougerat and L. Gamet-Payrastre},
journal = {Archives of Toxicology},
year = {2026},
month = sep,
doi = {10.1007/s00204-026-04533-6},
url = {https://hal.science/hal-05735886v1},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Diet modulates metabolic and hepatic responses to chronic pesticide mixture exposure in mice
AU - C. Rives
AU - N. Poirier-Jaouen
AU - Y. Malaisé
AU - C. Martin
AU - M. Huillet
AU - S. Ellero-Simatos
AU - P. Perrier
AU - A. Polizzi
AU - F. Lasserre
AU - V. Alquier-Bacquié
AU - C. Guyon
AU - Y. Lippi
AU - C. Naylies
AU - C. Comera
AU - H. Budzinski
AU - K. Le Menach
AU - E. Jamin
AU - N. Dieng
AU - R. Vuillaume
AU - C. Orlandi
AU - J. Gomez
AU - S. Costes
AU - A. Arrar
AU - A. Lucas
AU - S. Fried
AU - E. Boutet-Robinet
AU - J. Guillermet-Guibert
AU - E. Kesse-Guyot
AU - H. Guillou
AU - N. Loiseau
AU - A. Fougerat
AU - L. Gamet-Payrastre
PY - 2026
DA - 2026/09/03
JO - Archives of Toxicology
DO - 10.1007/s00204-026-04533-6
UR - https://hal.science/hal-05735886v1
AB - Chronic exposure to pesticide mixtures through diet is common, yet their combined metabolic effects and interactions with dietary factors remain unclear. We identified four pesticides prevalent in human exposure (imazalil, thiabendazole, boscalid, lambda-cyhalothrin) and assessed their combined impacts on hepatic metabolism and metabolic homeostasis using human liver cells and male mice fed standard chow or western diets. We found that the pesticide mixture induced metabolic perturbations in human hepatocytes. In addition, the pesticide mixture altered hepatic gene expression in chow-fed mice and exacerbated western diet-induced glucose intolerance, fasting hyperglycemia, and insulin resistance without affecting body weight or liver steatosis. These findings reveal that dietary context influences the metabolic consequences of pesticide mixtures, highlighting the need to consider nutritional status when evaluating environmental contaminant risks. Our results suggest that pesticide mixtures at reference doses may contribute to metabolic dysregulation, particularly under obesogenic dietary conditions.
SN - 0340-5761
SN - 1432-0738
ER -