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Peer-reviewedCC BY-NC-ND 4.0ACS Omega

Recyclability of Oxime Resin in Solid-Phase Peptide Synthesis

  • Olivier Laberge1
  • Normand Voyer1
  • Christopher Bérubé1
  1. 1Université Laval, Faculté des Sciences et de Génie , , 1045 Avenue de la Médecine , , ,
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Abstract

Greener approaches are essential to significantly reduce the environmental impact of solid phase peptide synthesis (SPPS). In this regard, we report a systematic study on the sustainable use of the Kaiser-DeGrado oxime resin. The reusability efficiency of this polystyrene-based resin was investigated through the synthesis of linear and cyclic model peptides with different structural features. We demonstrated that the oxime resin can be reused over multiple SPPS cycles without any special treatment, while still affording crude peptides in good purity and yield even after eight cycles. Furthermore, regeneration of the resin improved its efficiency approaching performances comparable to those of the freshly prepared resin. In addition, the same resin can be reused multiple times within a single reaction vessel using significantly fewer reagents and solvents, reducing material expenditures and waste while simplifying workflow.

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Cite

BibTeXRIS
BibTeX
@article{laberge2026recyclability,
  title = {{Recyclability of Oxime Resin in Solid-Phase Peptide Synthesis}},
  author = {Olivier Laberge and Normand Voyer and Christopher Bérubé},
  journal = {ACS Omega},
  year = {2026},
  month = oct,
  doi = {10.1021/acsomega.6c07935},
  url = {https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c07935/5453234/Recyclability-of-Oxime-Resin-in-Solid-Phase},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - Recyclability of Oxime Resin in Solid-Phase Peptide Synthesis
AU  - Olivier Laberge
AU  - Normand Voyer
AU  - Christopher Bérubé
PY  - 2026
DA  - 2026/10/17
JO  - ACS Omega
DO  - 10.1021/acsomega.6c07935
UR  - https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c07935/5453234/Recyclability-of-Oxime-Resin-in-Solid-Phase
AB  - Greener approaches are essential to significantly reduce the environmental impact of solid phase peptide synthesis (SPPS). In this regard, we report a systematic study on the sustainable use of the Kaiser-DeGrado oxime resin. The reusability efficiency of this polystyrene-based resin was investigated through the synthesis of linear and cyclic model peptides with different structural features. We demonstrated that the oxime resin can be reused over multiple SPPS cycles without any special treatment, while still affording crude peptides in good purity and yield even after eight cycles. Furthermore, regeneration of the resin improved its efficiency approaching performances comparable to those of the freshly prepared resin. In addition, the same resin can be reused multiple times within a single reaction vessel using significantly fewer reagents and solvents, reducing material expenditures and waste while simplifying workflow.
SN  - 2470-1343
ER  -