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Peer-reviewedCC BYeJHaem

Allogeneic Hematopoietic Stem Cell Transplantation Achieves Durable Remission in Blast‐Phase Chronic Myeloid Leukemia Presenting as Early T‐Cell Precursor Acute Lymphoblastic Leukemia

  • Takafumi Tsushima1
  • Yukiko Konishi1
  • Natsumi Yoda1
  • Koichiro Wada1
  • Kento Okamoto1
  • Kosuke Matsuo1
  • Shuntaro Isogai1
  • Sonoko Shimoji1
  • Yoshikazu Utsu1
  • Shin‐Ichi Masuda1
  • Nobuyuki Aotsuka1
  1. 1Department of Hematology and Oncology Japanese Red Cross Narita Hospital Narita Japan
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Abstract

Introduction The presentation of chronic myeloid leukemia (CML) in the blast phase as early T‐cell precursor acute lymphoblastic leukemia (ETP‐ALL) is very rare. As previously reported, in contrast to B‐ALL, the prognosis is poor. Case Presentation We encountered a patient with blast phase CML presenting as ETP‐ALL. The patient responded to treatment with dasatinib and Hyper CVAD. However, the BCR::ABL1 transcript levels remained positive, and the patient demonstrated resistance to switching to ponatinib and other agents. Eventually, the patient underwent allogeneic hematopoietic stem cell transplantation (HSCT) and has maintained long‐term molecular remission. Conclusion HSCT following remission induction therapy, inclusive of TKIs, may enhance prognosis for patients with blast phase CML presenting as ETP‐ALL. Trial Registration The authors have confirmed clinical trial registration is not needed for this submission.

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Cite

BibTeXRIS
BibTeX
@article{tsushima2026allogeneic,
  title = {{Allogeneic Hematopoietic Stem Cell Transplantation Achieves Durable Remission in Blast‐Phase Chronic Myeloid Leukemia Presenting as Early T‐Cell Precursor Acute Lymphoblastic Leukemia}},
  author = {Takafumi Tsushima and Yukiko Konishi and Natsumi Yoda and Koichiro Wada and Kento Okamoto and Kosuke Matsuo and Shuntaro Isogai and Sonoko Shimoji and Yoshikazu Utsu and Shin‐Ichi Masuda and Nobuyuki Aotsuka},
  journal = {eJHaem},
  year = {2026},
  month = oct,
  doi = {10.1002/jha2.70405},
  url = {https://doi.org/10.1002/jha2.70405},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Allogeneic Hematopoietic Stem Cell Transplantation Achieves Durable Remission in Blast‐Phase Chronic Myeloid Leukemia Presenting as Early T‐Cell Precursor Acute Lymphoblastic Leukemia
AU  - Takafumi Tsushima
AU  - Yukiko Konishi
AU  - Natsumi Yoda
AU  - Koichiro Wada
AU  - Kento Okamoto
AU  - Kosuke Matsuo
AU  - Shuntaro Isogai
AU  - Sonoko Shimoji
AU  - Yoshikazu Utsu
AU  - Shin‐Ichi Masuda
AU  - Nobuyuki Aotsuka
PY  - 2026
DA  - 2026/10/27
JO  - eJHaem
DO  - 10.1002/jha2.70405
UR  - https://doi.org/10.1002/jha2.70405
AB  - Introduction The presentation of chronic myeloid leukemia (CML) in the blast phase as early T‐cell precursor acute lymphoblastic leukemia (ETP‐ALL) is very rare. As previously reported, in contrast to B‐ALL, the prognosis is poor. Case Presentation We encountered a patient with blast phase CML presenting as ETP‐ALL. The patient responded to treatment with dasatinib and Hyper CVAD. However, the BCR::ABL1 transcript levels remained positive, and the patient demonstrated resistance to switching to ponatinib and other agents. Eventually, the patient underwent allogeneic hematopoietic stem cell transplantation (HSCT) and has maintained long‐term molecular remission. Conclusion HSCT following remission induction therapy, inclusive of TKIs, may enhance prognosis for patients with blast phase CML presenting as ETP‐ALL. Trial Registration The authors have confirmed clinical trial registration is not needed for this submission.
SN  - 2688-6146
ER  -