Prognostic Impact of COVID-19 on Patients With Acute Coronary Syndrome Undergoing Emergent Percutaneous Coronary Intervention ― Insights From the J-PCI Nationwide Registry ―
Abstract
BACKGROUND: Although the COVID-19 pandemic has impacted the management of acute coronary syndrome (ACS), the prognostic implications for ACS patients with concurrent COVID-19 undergoing percutaneous coronary intervention (PCI) remain to be determined, particularly in large nationwide cohorts. This study investigated the association between concomitant COVID-19 and clinical outcomes in patients undergoing emergent PCI for ACS. METHODS AND RESULTS: This retrospective cohort study utilized data from the Japanese Percutaneous Coronary Intervention (J-PCI) nationwide registry, encompassing all patients presenting with ACS who underwent primary or emergent PCI between January 2021 and December 2023. Multivariable logistic regression models were employed to ascertain the independent association between COVID-19 positivity and in-hospital all-cause and cardiovascular mortality. The analysis included 279,662 ACS patients, of whom 1,812 (0.65%) tested positive for COVID-19. After multivariable adjustment, COVID-19 remained an independent predictor of in-hospital all-cause mortality (adjusted odds ratio [aOR] 1.46; 95% confidence interval [CI] 1.21-1.77). The association between COVID-19 and cardiovascular mortality was significant in univariable analysis but not after multivariable adjustment (aOR 1.22; 95% CI 0.98-1.52). CONCLUSIONS: In this nationwide cohort, concomitant COVID-19 was independently associated with higher in-hospital all-cause mortality among patients with ACS undergoing PCI. These findings highlight the need for heightened surveillance and consideration of tailored therapeutic strategies in this high-risk population.
Related
- Comparative effectiveness of Orsiro, Xience, Synergy, and Resolute stent in patients with acute myocardial infarction undergoing percutaneous coronary intervention: a nationwide registry study
- Prognostic Implication of a CT-FFR-Based Functional SYNTAX Score in Coronary Artery Disease Patients Undergoing Percutaneous Coronary Intervention
- Prognostic value of chronic total occlusion complexity scoring systems beyond procedural planning: a comparative analysis of five contemporary scores in patients undergoing chronic total occlusion percutaneous coronary intervention
- Prognostic value of the apelin-12-to-white blood cell ratio for long-term major adverse cardiovascular events in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: a retrospective cohort study.
- Association Between Admission Calculated Serum Osmolality and New-Onset Atrial Fibrillation in Patients with Non-ST-Segment Elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention
BibTeX
@article{kanaji2026prognostic,
title = {{Prognostic Impact of COVID-19 on Patients With Acute Coronary Syndrome Undergoing Emergent Percutaneous Coronary Intervention ― Insights From the J-PCI Nationwide Registry ―}},
author = {Yoshihisa Kanaji and Kyohei Yamaji and Ayako Kunimura and Eisuke Usui and Tatsuhiro Nagamine and Hiroki Ueno and Mirei Setoguchi and Kodai Sayama and Hikaru Shimosato and Takahiro Watanabe and Takashi Mineo and Taishi Yonetsu and Yuichiro Mori and Shun Kohsaka and Hideki Ishii and Tetsuya Amano and Ken Kozuma and Tsunekazu Kakuta},
journal = {Circulation Journal},
year = {2026},
month = jul,
doi = {10.1253/circj.cj-25-0705},
url = {https://www.jstage.jst.go.jp/article/circj/90/8/90_CJ-25-0705/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Prognostic Impact of COVID-19 on Patients With Acute Coronary Syndrome Undergoing Emergent Percutaneous Coronary Intervention ― Insights From the J-PCI Nationwide Registry ―
AU - Yoshihisa Kanaji
AU - Kyohei Yamaji
AU - Ayako Kunimura
AU - Eisuke Usui
AU - Tatsuhiro Nagamine
AU - Hiroki Ueno
AU - Mirei Setoguchi
AU - Kodai Sayama
AU - Hikaru Shimosato
AU - Takahiro Watanabe
AU - Takashi Mineo
AU - Taishi Yonetsu
AU - Yuichiro Mori
AU - Shun Kohsaka
AU - Hideki Ishii
AU - Tetsuya Amano
AU - Ken Kozuma
AU - Tsunekazu Kakuta
PY - 2026
DA - 2026/07/24
JO - Circulation Journal
DO - 10.1253/circj.cj-25-0705
UR - https://www.jstage.jst.go.jp/article/circj/90/8/90_CJ-25-0705/_article
AB - BACKGROUND: Although the COVID-19 pandemic has impacted the management of acute coronary syndrome (ACS), the prognostic implications for ACS patients with concurrent COVID-19 undergoing percutaneous coronary intervention (PCI) remain to be determined, particularly in large nationwide cohorts. This study investigated the association between concomitant COVID-19 and clinical outcomes in patients undergoing emergent PCI for ACS. METHODS AND RESULTS: This retrospective cohort study utilized data from the Japanese Percutaneous Coronary Intervention (J-PCI) nationwide registry, encompassing all patients presenting with ACS who underwent primary or emergent PCI between January 2021 and December 2023. Multivariable logistic regression models were employed to ascertain the independent association between COVID-19 positivity and in-hospital all-cause and cardiovascular mortality. The analysis included 279,662 ACS patients, of whom 1,812 (0.65%) tested positive for COVID-19. After multivariable adjustment, COVID-19 remained an independent predictor of in-hospital all-cause mortality (adjusted odds ratio [aOR] 1.46; 95% confidence interval [CI] 1.21-1.77). The association between COVID-19 and cardiovascular mortality was significant in univariable analysis but not after multivariable adjustment (aOR 1.22; 95% CI 0.98-1.52). CONCLUSIONS: In this nationwide cohort, concomitant COVID-19 was independently associated with higher in-hospital all-cause mortality among patients with ACS undergoing PCI. These findings highlight the need for heightened surveillance and consideration of tailored therapeutic strategies in this high-risk population.
SN - 1347-4820
SN - 1346-9843
ER -