Clinical and radiologic predictors of one-year surgical outcomes in Crohn’s disease–related intra-abdominal abscesses
Abstract
To identify clinical and radiological prognostic factors associated with delayed surgery after diagnosis of a Crohn's disease-related intra-abdominal abscess.
MethodsWe conducted a retrospective single-center study including patients with Crohn's disease and confirmed intra-abdominal abscess, managed between 2012 and 2022.
The primary outcome was delayed surgery related to the index abscess, defined as bowel resection or surgical drainage performed between day 15 and one year after diagnosis. Clinical, biological, therapeutic, and imaging data were collected, and initial imaging studies were systematically reviewed. Hazard ratios (HR) were estimated using univariate and multivariate Cox models. Kaplan-Meier survival analyses and log-rank tests assessed time to surgery.
ResultsAmong 145 patients included, 59 underwent surgery within one year. In multivariate analysis, larger abscess long-axis diameter (HR = 1.22; 95% CI [1.09-1.35]; p < 0.001) and older age at abscess diagnosis (HR = 1.15; 95% CI [1.01-1.31]; p = 0.029) were associated with higher surgical risk. In contrast, older age at Crohn's disease diagnosis (HR = 0.83; 95% CI [0.72-0.96]; p = 0.011), collection morphology with mass effect compared with infiltrative morphology (HR = 0.80; 95% CI [0.65-0.99]; p = 0.038), and intravenous (IV) antibiotic therapy (HR = 0.79; 95% CI [0.64-0.97]; p = 0.024) were associated with reduced surgical risk. None of these factors significantly influenced time to surgery in Kaplan-Meier survival curve analysis.
ConclusionLarger abscesses and older age increased surgical risk, while IV antibiotics, welldefined morphology, and later Crohn's diagnosis reduced it.
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BibTeX
@article{su2026clinical,
title = {{Clinical and radiologic predictors of one-year surgical outcomes in Crohn’s disease–related intra-abdominal abscesses}},
author = {Caroline Su and Julien Kirchgesner and Pauline Iorio and Philipe Seksik and Harry Sokol and Lionel Arrivé and Mathilde Wagner and Quentin Vanderbecq},
journal = {European Journal of Radiology Open},
year = {2026},
month = jul,
doi = {10.1016/j.ejro.2026.100802},
url = {https://hal.science/hal-05789946v1},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Clinical and radiologic predictors of one-year surgical outcomes in Crohn’s disease–related intra-abdominal abscesses
AU - Caroline Su
AU - Julien Kirchgesner
AU - Pauline Iorio
AU - Philipe Seksik
AU - Harry Sokol
AU - Lionel Arrivé
AU - Mathilde Wagner
AU - Quentin Vanderbecq
PY - 2026
DA - 2026/07/27
JO - European Journal of Radiology Open
DO - 10.1016/j.ejro.2026.100802
UR - https://hal.science/hal-05789946v1
AB - To identify clinical and radiological prognostic factors associated with delayed surgery after diagnosis of a Crohn's disease-related intra-abdominal abscess. MethodsWe conducted a retrospective single-center study including patients with Crohn's disease and confirmed intra-abdominal abscess, managed between 2012 and 2022. The primary outcome was delayed surgery related to the index abscess, defined as bowel resection or surgical drainage performed between day 15 and one year after diagnosis. Clinical, biological, therapeutic, and imaging data were collected, and initial imaging studies were systematically reviewed. Hazard ratios (HR) were estimated using univariate and multivariate Cox models. Kaplan-Meier survival analyses and log-rank tests assessed time to surgery. ResultsAmong 145 patients included, 59 underwent surgery within one year. In multivariate analysis, larger abscess long-axis diameter (HR = 1.22; 95% CI [1.09-1.35]; p < 0.001) and older age at abscess diagnosis (HR = 1.15; 95% CI [1.01-1.31]; p = 0.029) were associated with higher surgical risk. In contrast, older age at Crohn's disease diagnosis (HR = 0.83; 95% CI [0.72-0.96]; p = 0.011), collection morphology with mass effect compared with infiltrative morphology (HR = 0.80; 95% CI [0.65-0.99]; p = 0.038), and intravenous (IV) antibiotic therapy (HR = 0.79; 95% CI [0.64-0.97]; p = 0.024) were associated with reduced surgical risk. None of these factors significantly influenced time to surgery in Kaplan-Meier survival curve analysis. ConclusionLarger abscesses and older age increased surgical risk, while IV antibiotics, welldefined morphology, and later Crohn's diagnosis reduced it.
SN - 2352-0477
ER -