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Peer-reviewedCC BYУкраїнський журнал клінічної хірургії

Microstructural changes in the small bowel wall as the basis for the development of intestinal failure syndrome in acute pancreatitis

  • V. P. Andriushchenko1
  • D. V. Andriushchenko1
  • O. V. Prykupenko1
  1. 1Danylo Halytsky Lviv National Medical University
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Abstract

Objective. To investigate the characteristics of pathohistological changes in the wall of the proximal small intestine as the morphological basis for the development of intestinal failure syndrome in patients with acute pancreatitis.

Materials and methods. A pathohistological examination of specimens – sections and biopsies of the small bowel wall – was carried out in 53 patients with acute pancreatitis, of whom 30 (57 per cent) had a moderately severe course and 23 (43 per cent) had a severe course. Specimens were obtained during fibrogastroduodenoscopy in 17 (32%) patients, during surgery in 24 (45%) and at autopsy in 12 (23%).

Results. Abnormalities in the structural elements of the small bowel wall manifested as signs of varying degrees of severity, extent and depth of inflammation: ranging from chronic – in 9 (17%) patients – to acute infiltrative–oedematous – in 7 (13%) – and diffuse enteritis with a component of destruction and erosive changes – in 37 (70%). Values of the villus height-to-crypt depth ratio ranging from 2.4 to 2.2 corresponded to a moderately severe degree of intestinal failure syndrome, whilst values ranging from 2.1 to 1.4 corresponded to a severe degree, which may serve as an objective criterion for assessing its severity.

Conclusions. Intestinal failure syndrome is one of the organ-specific complications of acute pancreatitis. The identified changes in the microstructure of the small bowel wall constitute its morphological basis.

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Cite

BibTeXRIS
BibTeX
@article{andriushchenko2026microstructural,
  title = {{Microstructural changes in the small bowel wall as the basis for the development of intestinal failure syndrome in acute pancreatitis}},
  author = {V. P. Andriushchenko and D. V. Andriushchenko and O. V. Prykupenko},
  journal = {Український журнал клінічної хірургії},
  year = {2026},
  month = oct,
  doi = {10.26779/2786-832x.2026.5.21},
  url = {https://doi.org/10.26779/2786-832x.2026.5.21},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Microstructural changes in the small bowel wall as the basis for the development of intestinal failure syndrome in acute pancreatitis
AU  - V. P. Andriushchenko
AU  - D. V. Andriushchenko
AU  - O. V. Prykupenko
PY  - 2026
DA  - 2026/10/23
JO  - Український журнал клінічної хірургії
DO  - 10.26779/2786-832x.2026.5.21
UR  - https://doi.org/10.26779/2786-832x.2026.5.21
AB  - Objective. To investigate the characteristics of pathohistological changes in the wall of the proximal small intestine as the morphological basis for the development of intestinal failure syndrome in patients with acute pancreatitis.  Materials and methods. A pathohistological examination of specimens – sections and biopsies of the small bowel wall – was carried out in 53 patients with acute pancreatitis, of whom 30 (57 per cent) had a moderately severe course and 23 (43 per cent) had a severe course. Specimens were obtained during fibrogastroduodenoscopy in 17 (32%) patients, during surgery in 24 (45%) and at autopsy in 12 (23%).  Results. Abnormalities in the structural elements of the small bowel wall manifested as signs of varying degrees of severity, extent and depth of inflammation: ranging from chronic – in 9 (17%) patients – to acute infiltrative–oedematous – in 7 (13%) – and diffuse enteritis with a component of destruction and erosive changes – in 37 (70%). Values of the villus height-to-crypt depth ratio ranging from 2.4 to 2.2 corresponded to a moderately severe degree of intestinal failure syndrome, whilst values ranging from 2.1 to 1.4 corresponded to a severe degree, which may serve as an objective criterion for assessing its severity.  Conclusions. Intestinal failure syndrome is one of the organ-specific complications of acute pancreatitis. The identified changes in the microstructure of the small bowel wall constitute its morphological basis.
SN  - 2786-832X
SN  - 2786-8311
ER  -