Effect of coffee bean chlorogenic acid on peripheral skin temperature and skin blood flow in healthy Japanese women with cold sensitivity: a placebo-controlled, randomized, double-blind, study.
- 1Skin Care Products Research, Kao Corporation, Bunka 2-1-3, Sumida-Ku, Tokyo, 131-8501, Japan.
- 2Human Health Care Products Research, Kao Corporation, Bunka 2-1-3, Sumida-Ku, Tokyo, 131-8501, Japan. [email protected].
- 3Faculty of Sport Science, Graduate School of Sport Sciences, Nihon Fukushi University, Okuda, Mihama-cho, Chita-gun, Aichi, 470-3295, Japan.
Abstract
Background
Cold sensitivity is a common health problem for women in Japan and in East Asia. Cold sensitivity is characterized by a low peripheral skin temperature (SkT) in a cold environment and a slow recovery of the peripheral SkT after cold exposure. Ingestion of coffee chlorogenic acids (CGAs) has been reported to improve the recovery of peripheral SkT and skin blood flow (SkBF) after cold stress. In this study, we investigated the acute effects of a single dose of CGA on peripheral SkT and SkBF in a cold environment.Methods
This randomized, double-blind, placebo-controlled, crossover study was conducted from February to March 2018. Twenty-three healthy Japanese women with cold sensitivity were randomly assigned to the CGA (270 mg) or the Placebo group in a crossover study with a one-week washout period (11 took CGA first and 12 took the Placebo first). Peripheral SkT (primary outcome) and SkBF (secondary outcome) were evaluated in a moderate cold environment (22 °C). The study was registered with the University Hospital Medical Information Network Clinical Trials Registry (UMIN000031184).Results
Twenty-one participants completed all crossover periods. The crossover analysis approach showed a significant period effect for SkT (p = 0.023) and therefore, only the first period data were analyzed. The ingestion of coffee bean CGA significantly suppressed the decrease in SkT (LS mean difference 1.18 °C, 95% confidence interval 0.16 to 2.19, F (1, 277) = 5.19, p = 0.023) and SkBF (LS mean difference 0.87 a.u., 95% confidence interval 0.41 to 1.69, F (1, 278) = 4.27, p = 0.040) during cold exposure. No adverse events attributed to the test beverage were observed.Conclusion
These results suggest that the ingestion of coffee bean CGA can suppress the decrease in SkT and SkBF in a cold environment.Trial registration
The name of this study is 'Examination of drink ingestion containing plant extract. NT-18002'. The study was registered with the University Hospital Medical Information Network Clinical Trials Registry. UMIN-CTR ( https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000035601 ) UMIN000031184. Registered on February 7, 2018.
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BibTeX
@article{nomura2026effect,
title = {{Effect of coffee bean chlorogenic acid on peripheral skin temperature and skin blood flow in healthy Japanese women with cold sensitivity: a placebo-controlled, randomized, double-blind, study.}},
author = {Tomoko Nomura and Yukinori Nakashima and Kazuya Kozuma and Akane Suma and Kazuhiko Higuchi and Naoki Nishimura},
journal = {Trials},
year = {2026},
month = aug,
doi = {10.1186/s13063-026-09928-5},
url = {https://europepmc.org/article/MED/42972432},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Effect of coffee bean chlorogenic acid on peripheral skin temperature and skin blood flow in healthy Japanese women with cold sensitivity: a placebo-controlled, randomized, double-blind, study.
AU - Tomoko Nomura
AU - Yukinori Nakashima
AU - Kazuya Kozuma
AU - Akane Suma
AU - Kazuhiko Higuchi
AU - Naoki Nishimura
PY - 2026
DA - 2026/08/06
JO - Trials
DO - 10.1186/s13063-026-09928-5
UR - https://europepmc.org/article/MED/42972432
AB - Background Cold sensitivity is a common health problem for women in Japan and in East Asia. Cold sensitivity is characterized by a low peripheral skin temperature (SkT) in a cold environment and a slow recovery of the peripheral SkT after cold exposure. Ingestion of coffee chlorogenic acids (CGAs) has been reported to improve the recovery of peripheral SkT and skin blood flow (SkBF) after cold stress. In this study, we investigated the acute effects of a single dose of CGA on peripheral SkT and SkBF in a cold environment.Methods This randomized, double-blind, placebo-controlled, crossover study was conducted from February to March 2018. Twenty-three healthy Japanese women with cold sensitivity were randomly assigned to the CGA (270 mg) or the Placebo group in a crossover study with a one-week washout period (11 took CGA first and 12 took the Placebo first). Peripheral SkT (primary outcome) and SkBF (secondary outcome) were evaluated in a moderate cold environment (22 °C). The study was registered with the University Hospital Medical Information Network Clinical Trials Registry (UMIN000031184).Results Twenty-one participants completed all crossover periods. The crossover analysis approach showed a significant period effect for SkT (p = 0.023) and therefore, only the first period data were analyzed. The ingestion of coffee bean CGA significantly suppressed the decrease in SkT (LS mean difference 1.18 °C, 95% confidence interval 0.16 to 2.19, F (1, 277) = 5.19, p = 0.023) and SkBF (LS mean difference 0.87 a.u., 95% confidence interval 0.41 to 1.69, F (1, 278) = 4.27, p = 0.040) during cold exposure. No adverse events attributed to the test beverage were observed.Conclusion These results suggest that the ingestion of coffee bean CGA can suppress the decrease in SkT and SkBF in a cold environment.Trial registration The name of this study is 'Examination of drink ingestion containing plant extract. NT-18002'. The study was registered with the University Hospital Medical Information Network Clinical Trials Registry. UMIN-CTR ( https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000035601 ) UMIN000031184. Registered on February 7, 2018.
SN - 1745-6215
ER -