Action Potential Thresholds and Excitability from the Geometry of Membrane Potential
- 1Facultad de Ciencias, Universidad Nacional Autonoma de Mexico
Abstract
A novel mathematical framework to define the threshold of action potentials in excitable cells is presented. Unlike previously applied methods that rely on approximations or bifurcations, the approach focuses on the geometry of membrane potential trajectories. The changes in concavity during the upstroke of an action potential can be directly obtained from a time series of voltages. The concavity criterion is then extended to models based on autonomous dynamical systems where the changes in concavity can be obtained analytically from a curve of inflection points in phase space. The inflection point manifold defines a region required for excitability: all the orbits that cross it contain action potentials, and all the trajectories that contain action potentials are in it. This analytical principle can then be used to define excitability in a dynamical system, and also a measure of excitability that enables quantification and comparisons of excitability across dynamical system. The measure provides a way to compare the excitabilities of systems that model neurons with different electrophysiological phenotypes and consider different stimulus conditions. The traditionally vague physiological concept of electrical excitability is transformed into a rigorous analytical description by considering the time-dependent curvature of the membrane potential. The criterion is robust across smooth, single compartment models of electrical excitability and can be can be extended to single compartment models in higher dimensions, and multicompartment models as well.
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BibTeX
@misc{herreravaldez2026action,
title = {{Action Potential Thresholds and Excitability from the Geometry of Membrane Potential}},
author = {M. A. Herrera-Valdez},
howpublished = {bioRxiv},
year = {2026},
month = aug,
doi = {10.64898/2026.08.21.746364},
url = {https://www.biorxiv.org/content/10.64898/2026.08.21.746364v2},
note = {CC BY},
}
RIS
TY - UNPB
TI - Action Potential Thresholds and Excitability from the Geometry of Membrane Potential
AU - M. A. Herrera-Valdez
PY - 2026
DA - 2026/08/21
PB - bioRxiv
DO - 10.64898/2026.08.21.746364
UR - https://www.biorxiv.org/content/10.64898/2026.08.21.746364v2
AB - A novel mathematical framework to define the threshold of action potentials in excitable cells is presented. Unlike previously applied methods that rely on approximations or bifurcations, the approach focuses on the geometry of membrane potential trajectories. The changes in concavity during the upstroke of an action potential can be directly obtained from a time series of voltages. The concavity criterion is then extended to models based on autonomous dynamical systems where the changes in concavity can be obtained analytically from a curve of inflection points in phase space. The inflection point manifold defines a region required for excitability: all the orbits that cross it contain action potentials, and all the trajectories that contain action potentials are in it. This analytical principle can then be used to define excitability in a dynamical system, and also a measure of excitability that enables quantification and comparisons of excitability across dynamical system. The measure provides a way to compare the excitabilities of systems that model neurons with different electrophysiological phenotypes and consider different stimulus conditions. The traditionally vague physiological concept of electrical excitability is transformed into a rigorous analytical description by considering the time-dependent curvature of the membrane potential. The criterion is robust across smooth, single compartment models of electrical excitability and can be can be extended to single compartment models in higher dimensions, and multicompartment models as well.
ER -