Null-model treatment of the sensory-motor boundary changes an evolutionary connectome comparison
Abstract
Randomised copies of a connectome are the usual baseline for asking whether measured wiring matters, and the answer depends on what the randomisation preserves. We evolved embodied foraging agents whose brains are a compressed adult Drosophila connectome (FlyWire v783; 512 cell-type groups and 1,000 Kenyon cells) alongside agents built on randomised wiring, in pre-registered experiments with ten seeds, four ecologies and 600 generations. Two standard randomisations, a column shuffle and degree-preserving edge swaps, route 10.6 to 10.7 % of olfactory output directly onto descending motor groups, against 0.012 % in the connectome. On the registered primary endpoint, fitness averaged over the run, no difference was detected; at the last common-garden probe the connectome was behind both controls (-0.22 and -0.20 fitness units on seed means). Against controls that keep every sensory-output and motor-input edge and rewire only the interior, the seed-mean difference lay within a +/-0.10 equivalence bound (+0.002 and -0.074, unchanged under a calibration that also matches activity spread), although per ecology the interior column shuffle was ahead by 0.26 in one of four ecologies at ten seeds, a lead that ten further pre-registered seeds did not replicate. Rewiring the connectome so that it acquires the shortcut raised its fitness by 0.44 (10 of 10 seeds) and its dependence on olfaction from 0.15 to 0.99; graded doses raised both in step; at comparable swap counts the full dose was ahead of an interior-only sham by 0.53 (10 of 10 seeds); and a sham that rewired the same boundary edges without creating shortcuts matched the connectome (+0.007) while the full dose was ahead of it by 0.60. What a null preserves at the sensory-motor boundary can decide an evolutionary connectome comparison, and sensory-to-motor path statistics belong next to the degree statistics a null is said to preserve.
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BibTeX
@misc{park2026nullmodel,
title = {{Null-model treatment of the sensory-motor boundary changes an evolutionary connectome comparison}},
author = {Gyujeong Park},
howpublished = {arXiv},
year = {2026},
month = sep,
doi = {10.48550/arxiv.2609.39248},
eprint = {2609.39248},
archivePrefix = {arXiv},
url = {https://arxiv.org/abs/2609.39248},
note = {CC BY 4.0},
}
RIS
TY - UNPB
TI - Null-model treatment of the sensory-motor boundary changes an evolutionary connectome comparison
AU - Gyujeong Park
PY - 2026
DA - 2026/09/30
PB - arXiv
DO - 10.48550/arxiv.2609.39248
UR - https://arxiv.org/abs/2609.39248
AB - Randomised copies of a connectome are the usual baseline for asking whether measured wiring matters, and the answer depends on what the randomisation preserves. We evolved embodied foraging agents whose brains are a compressed adult Drosophila connectome (FlyWire v783; 512 cell-type groups and 1,000 Kenyon cells) alongside agents built on randomised wiring, in pre-registered experiments with ten seeds, four ecologies and 600 generations. Two standard randomisations, a column shuffle and degree-preserving edge swaps, route 10.6 to 10.7 % of olfactory output directly onto descending motor groups, against 0.012 % in the connectome. On the registered primary endpoint, fitness averaged over the run, no difference was detected; at the last common-garden probe the connectome was behind both controls (-0.22 and -0.20 fitness units on seed means). Against controls that keep every sensory-output and motor-input edge and rewire only the interior, the seed-mean difference lay within a +/-0.10 equivalence bound (+0.002 and -0.074, unchanged under a calibration that also matches activity spread), although per ecology the interior column shuffle was ahead by 0.26 in one of four ecologies at ten seeds, a lead that ten further pre-registered seeds did not replicate. Rewiring the connectome so that it acquires the shortcut raised its fitness by 0.44 (10 of 10 seeds) and its dependence on olfaction from 0.15 to 0.99; graded doses raised both in step; at comparable swap counts the full dose was ahead of an interior-only sham by 0.53 (10 of 10 seeds); and a sham that rewired the same boundary edges without creating shortcuts matched the connectome (+0.007) while the full dose was ahead of it by 0.60. What a null preserves at the sensory-motor boundary can decide an evolutionary connectome comparison, and sensory-to-motor path statistics belong next to the degree statistics a null is said to preserve.
ER -