Metabolomic screening integrated with quality evaluation to pinpoint candidate markers in Chenpi infested by Tribolium castaneum
- 1School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
- 2Shandong Academy of Chinese Medicine, Jinan 250014, China
- 3State Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping/College of Plant Protection, Henan Agricultural University, Zhengzhou 450046, China
Abstract
This study evaluated the effects of Tribolium castaneum (TC) infestation on the quality of Citri Reticulatae Pericarpium (Chenpi) and identified potential infestation-related markers. Overall, infestation significantly reduced the contents of phenolic acids and flavonoids, as well as antioxidant activity. Untargeted UPLC-MS analysis annotated 1162 metabolites. Using VIP > 1, FC > 1.5 or < 0.66, and P < 0.05 (uncorrected) as screening criteria, 53 and 134 differential metabolites were identified in the 50 TC vs No TC and 100 TC vs No TC comparisons, respectively, with organoheterocyclic compounds showing the most pronounced increase in abundance. Enrichment analysis revealed that purine metabolism was significantly upregulated after infestation. In this pathway, uric acid, hypoxanthine, and xanthine accumulated markedly with increasing TC density and showed significant correlations with the quality deterioration of infested Chenpi. Therefore, these three purine-related metabolites were proposed as candidate markers associated with TC infestation.
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BibTeX
@article{cheng2026metabolomic,
title = {{Metabolomic screening integrated with quality evaluation to pinpoint candidate markers in Chenpi infested by Tribolium castaneum}},
author = {Yunxia Cheng and Meng Li and Qiujuan Ma and Jinrong Tang},
journal = {Food Chemistry: X},
year = {2026},
month = oct,
doi = {10.1016/j.fochx.2026.104686},
url = {https://doi.org/10.1016/j.fochx.2026.104686},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Metabolomic screening integrated with quality evaluation to pinpoint candidate markers in Chenpi infested by Tribolium castaneum
AU - Yunxia Cheng
AU - Meng Li
AU - Qiujuan Ma
AU - Jinrong Tang
PY - 2026
DA - 2026/10/25
JO - Food Chemistry: X
DO - 10.1016/j.fochx.2026.104686
UR - https://doi.org/10.1016/j.fochx.2026.104686
AB - This study evaluated the effects of Tribolium castaneum (TC) infestation on the quality of Citri Reticulatae Pericarpium (Chenpi) and identified potential infestation-related markers. Overall, infestation significantly reduced the contents of phenolic acids and flavonoids, as well as antioxidant activity. Untargeted UPLC-MS analysis annotated 1162 metabolites. Using VIP > 1, FC > 1.5 or < 0.66, and P < 0.05 (uncorrected) as screening criteria, 53 and 134 differential metabolites were identified in the 50 TC vs No TC and 100 TC vs No TC comparisons, respectively, with organoheterocyclic compounds showing the most pronounced increase in abundance. Enrichment analysis revealed that purine metabolism was significantly upregulated after infestation. In this pathway, uric acid, hypoxanthine, and xanthine accumulated markedly with increasing TC density and showed significant correlations with the quality deterioration of infested Chenpi. Therefore, these three purine-related metabolites were proposed as candidate markers associated with TC infestation.
SN - 2590-1575
ER -